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Cardiovascular and metabolic drugs

Isosorbide dinitrate

Also known as Isordil, Sorbidnitrate, Sorbitrate

CAS 87-33-2Formula C6H8N2O8Molar mass 236.14 g/molEC 201-740-9
GHS signal word: Warning. Pictograms: Harmful or irritant 67 suppliers listed Drug substance
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Isosorbide dinitrate chemical structure, C6H8N2O8, CAS 87-33-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Hard, colorless crystals
Melting point
70 °C
Solubility
In water, 550 mg/l @ 25 °C
HS code
293299
Category
Cardiovascular and metabolic drugs
UN number
UN 2907
Illustrative photo, colourless crystals beside a jumbo bulk bag in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Isosorbide dinitrate?

Plain description, key identifiers and synonyms

Isosorbide dinitrate is a nitrate ester and a glucitol derivative. It has a role as a vasodilator agent and a nitric oxide donor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(3S,3aS,6R,6aS)-3-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate
CAS number
87-33-2 CAS number cross-checkedOther or deprecated CAS: 1246815-45-1, 54650-95-2
EC number
201-740-9
Molecular formula
C6H8N2O8
UNII
IA7306519N
MDL number
MFCD00868238
InChIKey
MOYKHGMNXAOIAT-JGWLITMVSA-N
InChI
InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1
Canonical SMILES
O=[N+]([O-])OC1COC2C(O[N+](=O)[O-])COC12
Isomeric SMILES
C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O[N+](=O)[O-])O[N+](=O)[O-]

Synonyms

  • Isordil
  • Sorbidnitrate
  • Sorbitrate
  • Sorbide nitrate
  • Nitrosorbide
  • ISDN
  • Dinitrosorbide
  • Isoket
  • Dilatrate-SR
  • Carvasin
  • Cedocard
  • D-Isosorbide dinitrate
  • Sorbidilat
  • Vascardin
  • Flindix
  • Isorbid
  • Dilatrate
  • Sorbide, dinitrate
  • Isordil Tembids
  • Dinitroisosorbide
  • Isosorbide 2,5-dinitrate
  • Dianhydrosorbitol 2,5-dinitrate
  • Laserdil
  • D-Glucitol, 1,4:3,6-dianhydro-, dinitrate
  • 1,4:3,6-Dianhydro-D-glucitol dinitrate
Show all 39 synonyms
  • 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate
  • Isomannide-dinitrate
  • [(3S,3aS,6R,6aS)-3-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate
  • Isosorbidi dinitras dilutus
  • Diluted-isosorbide dinitrate
  • (3R,3aS,6S,6aS)-6-(nitrooxy)-hexahydrofuro[3,2-b]furan-3-yl nitrate
  • IsoBid
  • Iso Bid
  • Isoket Retard120
  • Dinitrate, Isosorbide
  • Angitak
  • Isocard
  • Jeridin
  • Sorbichew

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Hard, colorless crystalsexp.
Odour
ODORLESSexp.
Melting point
70 °Cexp.
Solubility
In water, 550 mg/l @ 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
236.14 g/molcalc.
Exact mass
236.0281 Dacalc.
LogP (octanol/water)
-1.06calc.
Topological polar surface area
123.2 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
4calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CC2OCCC2O1

C1CC2OCCC2O1

2 rings, 8 atoms, the 1,4:3,6-Dianhydro-2,5-dideoxyhexitol ring system.

149 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2907

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Isosorbide dinitrate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 67 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

67 suppliers in 16 countries

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Isosorbide dinitrate price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Nitric Oxide Donors
  • Vasodilator Agents

Roles

  • cardiovascular drug
  • donor
  • nitric oxide donor
  • pharmaceutical
  • vasodilator agent

Pharmacology

Isosorbide dinitrate is a Nitrate Vasodilator. The physiologic effect of isosorbide dinitrate is by means of Vasodilation.

How it is made

Preparation from sorbital

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Isosorbide dinitrate (INN), Ref no: 148, Annex ref: II/148
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Isosorbide dinitrate is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Isosorbide dinitrate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Isosorbide dinitrate, based on the data on this page

What is Isosorbide dinitrate?

Isosorbide dinitrate is a nitrate ester and a glucitol derivative. It has a role as a vasodilator agent and a nitric oxide donor.

What is the CAS number of Isosorbide dinitrate?

The CAS registry number of Isosorbide dinitrate is 87-33-2. Other or deprecated CAS numbers: 1246815-45-1, 54650-95-2.

What is the molecular formula and weight of Isosorbide dinitrate?

The molecular formula of Isosorbide dinitrate is C6H8N2O8 and its molar mass is 236.14 g/mol.

What is Isosorbide dinitrate used for?

Known uses and roles of Isosorbide dinitrate include cardiovascular drugs in pharmaceuticals, cardiovascular drug, donor, nitric oxide donor, pharmaceutical and 3 more.

Is Isosorbide dinitrate hazardous?

Isosorbide dinitrate carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Isosorbide dinitrate?

Isosorbide dinitrate is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Isosorbide dinitrate?

CompoundList lists 67 suppliers of Isosorbide dinitrate in China, United States, India, Germany and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Isosorbide dinitrate in India?

5 suppliers in India list Isosorbide dinitrate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Isosorbide dinitrate?

Suppliers quote Isosorbide dinitrate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Isosorbide dinitrate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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