CompoundList
Sign in
Pharmaceuticals and APIs

Ixabepilone

Also known as Azaepothilone B, Ixempra, Aza-epothilone B

CAS 219989-84-1Formula C27H42N2O5SMolar mass 506.71 g/molEC 630-424-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard, Hazardous to the environment 35 suppliers listed Drug substance
Get quotes Compare 35 suppliers
Ixabepilone chemical structure, C27H42N2O5S, CAS 219989-84-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
219989-84-1
Formula
C27H42N2O5S
Molar mass
506.71 g/mol
Appearance
Colorless oil or white lyopholizate
HS code
293410
Category
Pharmaceuticals and APIs
Illustrative photo, 200 litre blue HDPE drums of liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Ixabepilone?

Plain description, key identifiers and synonyms

Ixabepilone is a macrocycle that is a lactam analogue of epothilone B. Binds directly to beta-tubulin subunits on microtubules, leading to suppression of microtubule dynamics. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It is a lactam, an epoxide, a member of 1,3-thiazoles, a macrocycle and a beta-hydroxy ketone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
CAS number
219989-84-1 CAS number cross-checked
EC number
630-424-7
Molecular formula
C27H42N2O5S
UNII
K27005NP0A
MDL number
MFCD04307791
InChIKey
FABUFPQFXZVHFB-PVYNADRNSA-N
InChI
InChI=1S/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
Canonical SMILES
CC(=Cc1csc(C)n1)C1CC2OC2(C)CCCC(C)C(O)C(C)C(=O)C(C)(C)C(O)CC(=O)N1
Isomeric SMILES
C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](NC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C

Synonyms

  • Azaepothilone B
  • Ixempra
  • Aza-epothilone B
  • Ixempra kit
  • BMS 247550-01
  • ixabepilona
  • BMS 247550-1
  • BMS 247550
  • ixabepilonum
  • Epothilone-B BMS 247550
  • Ixempra (TN)
  • Ixabepilone?
  • Azi-epothilone B
  • Ixempra (TM)
  • 16-Aza-epothilone B
  • Ixabepilone (Standard)
  • Ixabepilone (JAN/USAN/INN)
  • Dihydroxy-1,5,7,9,9-pentamethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14.1.0]hep tadecane-8,12-dione
  • GZX

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless oil or white lyopholizateexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
506.71 g/molcalc.
Exact mass
506.2814 Dacalc.
LogP (octanol/water)
4.05calc.
Topological polar surface area
112.1 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
2calc.
Heavy atoms
35calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.74calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCCCCCC2OC2CC(C=Cc2cscn2)NC(=O)CCC1

O=C1CCCCCCC2OC2CC(C=Cc2cscn2)NC(=O)CCC1

3 rings, 26 atoms.

4 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H300Fatal if swallowed.
  • H301Toxic if swallowed.
  • H317May cause an allergic skin reaction.
  • H341Suspected of causing genetic defects.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H361fdSuspected of damaging fertility. Suspected of damaging the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (19)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ixabepilone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 35 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

35 suppliers in 12 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Ixabepilone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antineoplastic.

Roles

  • antimicrobial agent
  • antimitotic
  • antineoplastic agent
  • antiviral agent
  • microtubule-destabilising agent
  • pharmaceutical
  • tubulin modulator

Pharmacology

Ixabepilone is a Microtubule Inhibitor. The physiologic effect of ixabepilone is by means of Microtubule Inhibition.

How it is made

Preparation: G. D. Vite et al., WO 9902514, eidem, US 6605599 (1999, 2003 both to Bristol-Myers Squibb)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ixabepilone is traded under.

HS 2934.10Indicative HS code

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.88B
−16.1% vs 2023, imports $3.12B
2019 to 2024
Top exporters
  1. Switzerland * partner reported36.4%
  2. Ireland28.8%
  3. China10.0%
Top importers
  1. Canada33.4%
  2. United States14.4%
  3. Ireland13.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ixabepilone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ixabepilone, based on the data on this page

What is Ixabepilone?

Ixabepilone is a macrocycle that is a lactam analogue of epothilone B. Binds directly to beta-tubulin subunits on microtubules, leading to suppression of microtubule dynamics. It has a role as an antineoplastic agent and a microtubule-destabilising agent.

What is the CAS number of Ixabepilone?

The CAS registry number of Ixabepilone is 219989-84-1.

What is the molecular formula and weight of Ixabepilone?

The molecular formula of Ixabepilone is C27H42N2O5S and its molar mass is 506.71 g/mol.

What is Ixabepilone used for?

Therapeutic category: Antineoplastic.

Is Ixabepilone hazardous?

Ixabepilone carries the GHS signal word "Danger". Main hazards: fatal if swallowed, toxic if swallowed, may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ixabepilone?

Ixabepilone is usually classified under HS code 293410 (Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ixabepilone?

CompoundList lists 35 suppliers of Ixabepilone in China, United States, Germany, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ixabepilone in India?

2 suppliers in India list Ixabepilone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ixabepilone?

Suppliers quote Ixabepilone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ixabepilone

Get quotes for Ixabepilone

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Ixabepilone
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Ixabepilone with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/ixabepilone-219989-84-1" title="Ixabepilone structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Pharmaceuticals and APIs or HS code 293410

35 suppliers
Free quotes, contact stays private
Get quotes