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Vitamins and nutraceutical actives

L-Methylfolate

Also known as Levomefolic acid, Levomefolinic acid, LMSR

CAS 31690-09-2Formula C20H25N7O6Molar mass 459.46 g/mol
35 suppliers listed Drug substance
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L-Methylfolate chemical structure, C20H25N7O6, CAS 31690-09-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
31690-09-2
Formula
C20H25N7O6
Molar mass
459.46 g/mol
HS code
293980
Category
Vitamins and nutraceutical actives

What is L-Methylfolate?

Plain description, key identifiers and synonyms

5-methyltetrahydrofolic acid is a tetrahydrofolic acid that is 5,6,7,8-tetrahydrofolic acid substituted by a methyl group at position 5. It has a role as a human metabolite. It is functionally related to a 5,6,7,8-tetrahydrofolic acid. It is a conjugate acid of a 5-methyltetrahydrofolate(2-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
CAS number
31690-09-2 CAS number cross-checked
Molecular formula
C20H25N7O6
UNII
8S95DH25XC
MDL number
MFCD00870135
InChIKey
ZNOVTXRBGFNYRX-STQMWFEESA-N
InChI
InChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12-,13-/m0/s1
Canonical SMILES
CN1c2c(nc(N)[nH]c2=O)NCC1CNc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1
Isomeric SMILES
CN1[C@H](CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

Synonyms

  • Levomefolic acid
  • Levomefolinic acid
  • LMSR
  • L-5-MTHF
  • Nutrifolin
  • Acido levomefolico
  • 5-methyl-(6s)-tetrahydrofolic acid
  • Acide levomefolique
  • (2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
  • (2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
  • L-methyl folate
  • acidum levomefolicum
  • (2S)-2-((4-(((6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino)benzoyl)amino)pentanedioic acid
  • (2S)-2-((4-(((6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino)benzoyl)amino)pentanedioic acid
  • L-methyltetrahydrofolate
  • 5-methyltetrahydrofolate, (L-Glu)-(S)-
  • N-(4-((((6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate
  • 5-mthf
  • Deplin
  • Levomefolate
  • Levomefolicacid
  • L-5-Methyltetrahydrofolate
  • 5-Methyltetrahydrofolate
  • (6S)-5-methyltetrahydrofolate
  • 5- methyltetrahydrofolate
Show all 36 synonyms
  • (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid
  • [(6S)-5-methyl-5,6,7,8-tetrahydropteroyl]glutamate
  • (S)-N-[4-[[(2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
  • N-(5-methyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
  • Metafolin (TN)
  • (2S)-2-{[4-({[(6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid
  • N-[4-({[(6S)-2-amino-4-hydroxy-5-methyl-5,6,7,8-tetrahydropteridin-6-yl]methyl}amino)benzoyl]-l-glutamic acid
  • THH
  • L-5-Methyltetrahydrofolic acid
  • (6s)-5-methyltetrahydrofolic acid
  • N-(4-((((6S)-2-Amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
459.46 g/molcalc.
Exact mass
459.1866 Dacalc.
LogP (octanol/water)
-0.26calc.
Topological polar surface area
202.8 Ųcalc.
Hydrogen bond donors
7calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
9calc.
Heavy atoms
33calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]cnc2c1NC(CNc1ccccc1)CN2

O=c1[nH]cnc2c1NC(CNc1ccccc1)CN2

3 rings, 19 atoms.

85 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

L-Methylfolate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 35 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

35 suppliers in 8 countries

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L-Methylfolate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • Saccharomyces cerevisiae metabolite
  • animal metabolite
  • eukaryotic metabolite
  • fungal metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite

Pharmacology

Levomefolic acid is a Folate Analog.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code L-Methylfolate is traded under.

HS 2939.80Indicative HS code

Natural or reproduced by synthesis, and their salts, esters and other derivatives not elsewhere classified…

World exports in 2024
$49.3M
+13.2% vs 2023, imports $61.4M
2019 to 2024
Top exporters
  1. China31.7%
  2. India * partner reported23.1%
  3. South Africa7.8%
Top importers
  1. Austria28.6%
  2. United States11.9%
  3. United Kingdom7.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for L-Methylfolate is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about L-Methylfolate, based on the data on this page

What is L-Methylfolate?

5-methyltetrahydrofolic acid is a tetrahydrofolic acid that is 5,6,7,8-tetrahydrofolic acid substituted by a methyl group at position 5. It has a role as a human metabolite. It is functionally related to a 5,6,7,8-tetrahydrofolic acid. It is a conjugate acid of a 5-methyltetrahydrofolate(2-).

What is the CAS number of L-Methylfolate?

The CAS registry number of L-Methylfolate is 31690-09-2.

What is the molecular formula and weight of L-Methylfolate?

The molecular formula of L-Methylfolate is C20H25N7O6 and its molar mass is 459.46 g/mol.

What is L-Methylfolate used for?

Known uses and roles of L-Methylfolate include vitamins and supplements in pharmaceuticals, vitamins, minerals and nutrients in food and beverage, feed vitamins in animal feed and nutrition, saccharomyces cerevisiae metabolite, animal metabolite and 5 more.

Is L-Methylfolate hazardous?

No GHS hazard classification for L-Methylfolate is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of L-Methylfolate?

L-Methylfolate is usually classified under HS code 293980 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy L-Methylfolate?

CompoundList lists 35 suppliers of L-Methylfolate in China, United States, India, Spain and 4 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy L-Methylfolate in India?

7 suppliers in India list L-Methylfolate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of L-Methylfolate?

Suppliers quote L-Methylfolate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle L-Methylfolate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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