CompoundList
Sign in
Amino acids and derivatives

L-Phenylalanine

Also known as phenylalanine, (S)-2-Amino-3-phenylpropanoic acid, (2S)-2-amino-3-phenylpropanoic acid

CAS 63-91-2Formula C9H11NO2Molar mass 165.19 g/molEC 200-568-1
181 suppliers listed Drug substance
Get quotes Compare 181 suppliers
L-Phenylalanine chemical structure, C9H11NO2, CAS 63-91-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Prisms form water
Melting point
283 ยฐC
Boiling point
295 ยฐC
Solubility
Monoclinic leaflets or prisms from water or alchol, sweetish taste. Decomposes at 271-27โ€ฆ
HS code
292249
Category
Amino acids and derivatives
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is L-Phenylalanine?

Plain description, key identifiers and synonyms

L-phenylalanine is the L-enantiomer of phenylalanine. It has a role as a micronutrient, a nutraceutical, an EC 3.1.3.1 (alkaline phosphatase) inhibitor, a mouse metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite, a human xenobiotic metabolite, an Escherichia coli metabolite and an algal metabolite. It is a L-alpha-amino acid, a phenylalanine, an erythrose 4-phosphate/phosphoenolpyruvate family amino acid and a proteinogenic amino acid. It is a conjugate base of a L-phenylalaninium. It is a conjugate acid of a L-phenylalaninate. It is an enantiomer of a D-phenylalanine. It is a tautomer of a L-phenylalanine zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-amino-3-phenylpropanoic acid
CAS number
63-91-2 CAS number cross-checkedOther or deprecated CAS: 150-30-1, 25191-15-5, 67675-33-6
EC number
200-568-1
Molecular formula
C9H11NO2
UNII
47E5O17Y3R
MDL number
MFCD00064227
INCI name
PHENYLALANINE
InChIKey
COLNVLDHVKWLRT-QMMMGPOBSA-N
InChI
InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
Canonical SMILES
NC(Cc1ccccc1)C(=O)O
Isomeric SMILES
C1=CC=C(C=C1)C[C@@H](C(=O)O)N

Synonyms

  • phenylalanine
  • (S)-2-Amino-3-phenylpropanoic acid
  • (2S)-2-amino-3-phenylpropanoic acid
  • 3-Phenyl-L-alanine
  • (S)-Phenylalanine
  • (L)-Phenylalanine
  • 3-Phenylalanine
  • beta-Phenyl-L-alanine
  • (S)-2-Amino-3-phenylpropionic acid
  • Antibiotic FN 1636
  • L-Alanine, phenyl-
  • Alanine, 3-phenyl-
  • fenilalanina
  • L-Alanine, 3-phenyl-
  • (S)-alpha-Amino-beta-phenylpropionic acid
  • Phenylalaninum
  • Alanine, phenyl-, L-
  • (S)-alpha-Aminohydrocinnamic acid
  • (S)-alpha-Amino-benzenepropanoic acid
  • Phenylalanine, L-
  • (S)-(-)-Phenylalanine
  • Hydrocinnamic acid, alpha-amino-
  • laevo-phenyl alanine
  • L-Phe
  • alpha-Aminohydrocinnamic acid
Show all 38 synonyms
  • Benzenepropanoic acid, alpha-amino-, (S)-
  • Phenylalamine
  • (-)-beta-Phenylalanine
  • beta-Phenyl-alpha-alanine
  • (S)-alpha-Aminobenzenepropanoic acid
  • L-2-Amino-3-phenylpropionic acid
  • Phenyl-alpha-alanine
  • L-Isomer Phenylalanine
  • l-phenylalaninum
  • Phenylalanine, L
  • L-Phenylalanine High
  • Phenylalanine 1532
  • Phenylalanine Phenolic

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Prisms form waterexp.
Odour
Slightexp.
Taste
Bitterexp.
Melting point
283 ยฐCexp.
Boiling point
295 ยฐCexp.
Solubility
Monoclinic leaflets or prisms from water or alchol, sweetish taste. Decomposes at 271-273 ยฐC. Sublimes in vacuo. pK1 = 2.58, pK2 = 9.24.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
165.19 g/molcalc.
Exact mass
165.079 Dacalc.
LogP (octanol/water)
0.64calc.
Topological polar surface area
63.32 ร…ยฒcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
12calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.22calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS classification
Hazard pictograms

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

L-Phenylalanine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 181 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

181 suppliers in 24 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

L-Phenylalanine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Component of the artifical sweetener aspartame ... nutrient.

Reported uses

Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association) [Table#3675].

Medicine and nutrition[Lewis RJ Sr, Hawley's Condensed Chemical Dictionary 15th ed Wiley (2007).

Used with aspartic acid in the manufacture of aspartame.

Biological activities: AntiADD, Antidepressant, Antiparkinsonian, Antisickling, Antivitiligic, Monoamine-Precursor, Tremorigenic (Phenylalanine).

Use classes: Cosmetics.

Cosmetic ingredient, INCI name PHENYLALANINE(hair conditioning, fragrance, skin conditioning)

Roles

  • Escherichia coli metabolite
  • Saccharomyces cerevisiae metabolite
  • algal metabolite
  • animal metabolite
  • bacterial metabolite
  • enzyme inhibitor
  • eukaryotic metabolite
  • food component
  • fungal metabolite
  • human metabolite
  • human xenobiotic metabolite
  • mammalian metabolite
  • metabolite
  • micronutrient
  • mouse metabolite
  • nutraceutical
  • nutrient
  • pharmaceutical
  • physiological role
  • plant metabolite
  • prokaryotic metabolite
  • xenobiotic metabolite

Functional uses

  • Flavouring and nutrient

Cosmetic functions

  • Fragrance
  • Hair conditioning
  • Skin conditioning

Pharmacology

Phenylalanine is an essential aromatic amino acid in humans (provided by food), Phenylalanine plays a key role in the biosynthesis of other amino acids and is important in the structure and function of many proteins and enzymes. Phenylalanine is converted to tyrosine, used in the biosynthesis of dopamine and norepinephrine neurotransmitters. The L-form of Phenylalanine is incorporated into proteins, while the D-form acts as a painkiller. Absorption of ultraviolet radiation by Phenylalanine is used to quantify protein amounts. (NCI04)

How it is made

From PTS-negative Escherichia coli bioengineered strains.

(L(-))-phenylalanine is isolated commercially from proteins (ovalbumin, lactalbumin, zein, and fibrin).

Fermentation from carbohydrates is the most economical way to produce L-phenylalanine

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code L-Phenylalanine is traded under.

HS 2922.49Indicative HS code

Amino-acids, other than those containing more than one kind of oxygen function, andโ€ฆ

World exports in 2024
$3.88B
โˆ’11.5% vs 2023, imports $3.87B
2019 to 2024
Top exporters
  1. China38.7%
  2. India * partner reported8.3%
  3. Germany8.1%
Top importers
  1. United States13.4%
  2. Germany11.1%
  3. Japan6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for L-Phenylalanine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about L-Phenylalanine, based on the data on this page

What is L-Phenylalanine?

L-phenylalanine is the L-enantiomer of phenylalanine. It has a role as a micronutrient, a nutraceutical, an EC 3.1.3.1 (alkaline phosphatase) inhibitor, a mouse metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite, a human xenobiotic metabolite, an Escherichia coli metabolite and an algal metabolite.

What is the CAS number of L-Phenylalanine?

The CAS registry number of L-Phenylalanine is 63-91-2. Other or deprecated CAS numbers: 150-30-1, 25191-15-5, 67675-33-6.

What is the molecular formula and weight of L-Phenylalanine?

The molecular formula of L-Phenylalanine is C9H11NO2 and its molar mass is 165.19 g/mol.

What is L-Phenylalanine used for?

Component of the artifical sweetener aspartame ... nutrient. Reported uses Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association) [Table#3675]. Medicine and nutrition[Lewis RJ Sr, Hawley's Condensed Chemical Dictionary 15th ed Wiley (2007). Used with aspartic acid in the manufacture of aspartame.

Is L-Phenylalanine hazardous?

No GHS hazard classification for L-Phenylalanine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of L-Phenylalanine?

L-Phenylalanine is usually classified under HS code 292249 (Amino-acids, other than those containing more than one kind of oxygen function, andโ€ฆ). This is indicative, confirm it with your customs broker before shipping.

Where can I buy L-Phenylalanine?

CompoundList lists 181 suppliers of L-Phenylalanine in China, United States, Germany, India and 20 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy L-Phenylalanine in India?

9 suppliers in India list L-Phenylalanine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of L-Phenylalanine?

Suppliers quote L-Phenylalanine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle L-Phenylalanine

Get quotes for L-Phenylalanine

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell L-Phenylalanine
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of L-Phenylalanine with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/l-phenylalanine-63-91-2" title="L-Phenylalanine structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Amino acids and derivatives or HS code 292249

181 suppliers
Free quotes, contact stays private
Get quotes