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Pharmaceuticals and APIs

Leniolisib

Also known as Cdz173 free base, Cdz-173 free base, leniolisibum

CAS 1354690-24-6Formula C21H25F3N6O2Molar mass 450.47 g/mol
1 supplier listed Drug substance
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Leniolisib chemical structure, C21H25F3N6O2, CAS 1354690-24-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1354690-24-6
Formula
C21H25F3N6O2
Molar mass
450.47 g/mol
HS code
293359
Category
Pharmaceuticals and APIs

What is Leniolisib?

Plain description, key identifiers and synonyms

Leniolisib is a pyridopyrimidine that is 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine substituted by [(3S)-1-propanoylpyrrolidin-3-yl]amino and 6-methoxy-5-(trifluoromethyl)pyridin-3-yl groups at positions 4 and 6, respectively. It has a role as an EC 2.7.1.153 (phosphatidylinositol-4,5-bisphosphate 3-kinase) inhibitor and an immunomodulator. It is a tertiary carboxamide, a member of pyridines, an aromatic ether, an organofluorine compound, a member of pyrrolidines, a pyridopyrimidine and a secondary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one
CAS number
1354690-24-6
Molecular formula
C21H25F3N6O2
UNII
L22772Z9CP
MDL number
MFCD30470232
InChIKey
MWKYMZXCGYXLPL-ZDUSSCGKSA-N
InChI
InChI=1S/C21H25F3N6O2/c1-3-18(31)30-6-4-13(10-30)28-19-15-11-29(7-5-17(15)26-12-27-19)14-8-16(21(22,23)24)20(32-2)25-9-14/h8-9,12-13H,3-7,10-11H2,1-2H3,(H,26,27,28)/t13-/m0/s1
Canonical SMILES
CCC(=O)N1CCC(Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1
Isomeric SMILES
CCC(=O)N1CC[C@@H](C1)NC2=NC=NC3=C2CN(CC3)C4=CC(=C(N=C4)OC)C(F)(F)F

Synonyms

  • Cdz173 free base
  • Cdz-173 free base
  • leniolisibum
  • 1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one
  • 1-Propanone, 1-((3S)-3-((5,6,7,8-tetrahydro-6-(6-methoxy-5-(trifluoromethyl)-3-pyridinyl)pyrido(4,3-d)pyrimidin-4-yl)amino)-1-pyrrolidinyl)-
  • 1-((3S)-3-((6-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-7,8-dihydro-5H-pyrido(4,3-d)pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one
  • (S)-1-(3-((6-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one
  • Leniolisib free base
  • leniolisib (CDZ 173)
  • Leniolisib (CDZ173)
  • Leniolisib, CDZ173
  • Leniolisib (USAN/INN)
  • Leniolisib (CDZ173)?
  • CDZ 173
  • Example 67
  • 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-y
  • 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one
  • US8653092, 67
  • 1-((3S)-3-((6-(6-Methoxy-5-(trifluoromethyl)pyrimidin-3-yl)-5,6,7,8-tetrahydropyrido(4,3-d)pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one
  • 1-[(3S)-3-({6-[6-methoxy-5-(trifluoromethyl)pyridin-3-yl]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl}amino)pyrrolidin-1-yl]propan-1-one
  • 1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one
  • 1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)-3-pyridyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
450.47 g/molcalc.
Exact mass
450.1991 Dacalc.
LogP (octanol/water)
2.88calc.
Topological polar surface area
83.48 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
5calc.
Heavy atoms
32calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.52calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cncc(N2CCc3ncnc(NC4CCNC4)c3C2)c1

c1cncc(N2CCc3ncnc(NC4CCNC4)c3C2)c1

4 rings, 22 atoms.

4 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Leniolisib suppliers

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Leniolisib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Phosphoinositide-3 Kinase Inhibitors

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • immunomodulator
  • pharmaceutical

Pharmacology

Leniolisib is a Kinase Inhibitor. The mechanism of action of leniolisib is as a Phosphoinositide 3-Kinase delta Inhibitor, and Cytochrome P450 1A2 Inhibitor, and Breast Cancer Resistance Protein Inhibitor, and Organic Anion Transporting Polypeptide 1B1 Inhibitor, and Organic Anion Transporting Polypeptide 1B3 Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Leniolisib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Leniolisib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Leniolisib, based on the data on this page

What is Leniolisib?

Leniolisib is a pyridopyrimidine that is 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine substituted by [(3S)-1-propanoylpyrrolidin-3-yl]amino and 6-methoxy-5-(trifluoromethyl)pyridin-3-yl groups at positions 4 and 6, respectively.

What is the CAS number of Leniolisib?

The CAS registry number of Leniolisib is 1354690-24-6.

What is the molecular formula and weight of Leniolisib?

The molecular formula of Leniolisib is C21H25F3N6O2 and its molar mass is 450.47 g/mol.

What is Leniolisib used for?

Known uses and roles of Leniolisib include antineoplastic agent, enzyme inhibitor, immunomodulator, pharmaceutical and phosphoinositide-3 kinase inhibitors.

Is Leniolisib hazardous?

No GHS hazard classification for Leniolisib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Leniolisib?

Leniolisib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Leniolisib?

CompoundList lists 1 supplier of Leniolisib in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Leniolisib?

Suppliers quote Leniolisib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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