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Analgesics and anti-inflammatories

Levomepromazine

Also known as Methotrimeprazine, Levoprome, Neozine

CAS 60-99-1Formula C19H24N2OSMolar mass 328.48 g/molEC 200-495-5
GHS signal word: Warning. Pictograms: Harmful or irritant 20 suppliers listed
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Levomepromazine chemical structure, C19H24N2OS, CAS 60-99-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
60-99-1
Formula
C19H24N2OS
Molar mass
328.48 g/mol
EC number
200-495-5
HS code
293430
Category
Analgesics and anti-inflammatories

What is Levomepromazine?

Plain description, key identifiers and synonyms

Methotrimeprazine is a member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively. It has a role as an anticoronaviral agent, a non-narcotic analgesic, a phenothiazine antipsychotic drug, a serotonergic antagonist, a dopaminergic antagonist, a cholinergic antagonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is a tertiary amine and a member of phenothiazines. It derives from a hydride of a 10H-phenothiazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
CAS number
60-99-1 CAS number cross-checked
EC number
200-495-5
Molecular formula
C19H24N2OS
UNII
9G0LAW7ATQ
InChIKey
VRQVVMDWGGWHTJ-CQSZACIVSA-N
InChI
InChI=1S/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3/t14-/m1/s1
Canonical SMILES
COc1ccc2c(c1)N(CC(C)CN(C)C)c1ccccc1S2
Isomeric SMILES
C[C@@H](CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C

Synonyms

  • Methotrimeprazine
  • Levoprome
  • Neozine
  • Levomepromazina
  • Nirvan
  • Levomepromazinum
  • 2-Methoxytrimeprazine
  • Levopromazine
  • Nosinan
  • SK&F 5116
  • CL 36467
  • CL 39743
  • RP 7044
  • Bayer 1213
  • Arc-VI-C-5
  • SK&F-5116
  • (-)-(2R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
  • (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine
  • (2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
  • [(2R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]dimethylamine
  • 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (R)-
  • Levomeprazin
  • Tizercine
  • Tizertsin
  • 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (betaR)-
Show all 38 synonyms
  • ((2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl)dimethylamine
  • Nozinan
  • Levomepromazin
  • Tisercin
  • Levomeprazine
  • Mepromazine
  • Levopromethazine
  • (R)-Methotrimeprazine
  • Nozinane
  • Sinogan
  • Sinogan-Debil
  • Levotomin
  • Methotrimeprazine (USP)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
328.48 g/molcalc.
Exact mass
328.1609 Dacalc.
LogP (octanol/water)
4.5calc.
Topological polar surface area
15.71 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
5calc.
Heavy atoms
23calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.37calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Nc1ccccc1S2

c1ccc2c(c1)Nc1ccccc1S2

3 rings, 14 atoms, the Phenothiazine ring system.

1,001 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
Precautionary statements (13)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Levomepromazine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 20 suppliers
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Where suppliers are based

20 suppliers in 9 countries

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Levomepromazine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Analgesics, Non-Narcotic
  • Antipsychotic Agents
  • Dopamine Antagonists

Roles

  • analgesic
  • antagonist
  • anticoronaviral agent
  • antidepressant
  • antimicrobial agent
  • antipsychotic agent
  • antiviral agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • cholinergic antagonist
  • cholinergic drug
  • dopaminergic agent
  • dopaminergic antagonist
  • enzyme inhibitor
  • first generation antipsychotic
  • neurotransmitter agent
  • non-narcotic analgesic
  • pharmaceutical
  • phenothiazine antipsychotic drug
  • psychotropic drug
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

Pharmacology

Levomepromazine is a phenothiazine and typical antipsychotic agent, with sedative/hypnotic, anxiolytic, antiemetic, analgesic and antipsychotic activities. Although the exact mechanism of action of levomepromazine is not fully known, upon administration, this agent appears to act as an antagonist for a variety of receptors in the central nervous system (CNS), including adrenergic, dopamine, histamine, cholinergic and serotonin (5-hydroxytryptamine, 5-HT) receptors. Blocking these receptors results in levomepromazine's pharmacologic effects.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Levomepromazine is traded under.

HS 2934.30Indicative HS code

Compounds containing in the structure a phenothiazine ring-system (whether or not…

World exports in 2024
$89.3M
−7.1% vs 2023, imports $97M
2019 to 2024
Top exporters
  1. Germany21.6%
  2. France * partner reported14.6%
  3. China13.0%
Top importers
  1. United States14.2%
  2. Brazil12.7%
  3. India * partner reported10.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Levomepromazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Levomepromazine, based on the data on this page

What is Levomepromazine?

Methotrimeprazine is a member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.

What is the CAS number of Levomepromazine?

The CAS registry number of Levomepromazine is 60-99-1.

What is the molecular formula and weight of Levomepromazine?

The molecular formula of Levomepromazine is C19H24N2OS and its molar mass is 328.48 g/mol.

What is Levomepromazine used for?

Use classes: Pharmaceuticals.

Is Levomepromazine hazardous?

Levomepromazine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Levomepromazine?

Levomepromazine is usually classified under HS code 293430 (Compounds containing in the structure a phenothiazine ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Levomepromazine?

CompoundList lists 20 suppliers of Levomepromazine in China, United States, Bangladesh, Brazil and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Levomepromazine in India?

1 supplier in India list Levomepromazine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Levomepromazine?

Suppliers quote Levomepromazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Levomepromazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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