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Cardiovascular and metabolic drugs

Lomitapide

Also known as AEGR-733, Lojuxta, BMS 201038

CAS 182431-12-5Formula C39H37F6N3O2Molar mass 693.73 g/mol
11 suppliers listed Drug substance
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Lomitapide chemical structure, C39H37F6N3O2, CAS 182431-12-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
182431-12-5
Formula
C39H37F6N3O2
Molar mass
693.73 g/mol
HS code
293339
Category
Cardiovascular and metabolic drugs

What is Lomitapide?

Plain description, key identifiers and synonyms

Lomitapide is a member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. It has a role as an anticholesteremic drug and a MTP inhibitor. It is a member of benzamides, a member of fluorenes, a member of piperidines and a member of (trifluoromethyl)benzenes. It is a conjugate base of a lomitapide(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
CAS number
182431-12-5 CAS number cross-checked
Molecular formula
C39H37F6N3O2
UNII
82KUB0583F
MDL number
MFCD16620494
InChIKey
MBBCVAKAJPKAKM-UHFFFAOYSA-N
InChI
InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
SMILES (canonical and isomeric)
C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F

Synonyms

  • AEGR-733
  • Lojuxta
  • BMS 201038
  • AEGR733
  • lomitapida
  • lomitapidum
  • N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
  • 9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)(1,1'-biphenyl)-2-yl)carbonyl)amino)-1-piperidinyl)butyl)-
  • 9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-
  • N-(2,2,2-Trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)biphenyl-2-yl)carbonyl)amino)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide
  • N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide
  • N-(2,2,2-trifluoroethyl)-9-(4-(4-((2-(4-(trifluoromethyl)phenyl)benzoyl)amino)piperidin-1-yl)butyl)fluorene-9-carboxamide
  • Juxtapid
  • AEGR 733
  • AEGR-733, BMS-201038
  • AEGR-773
  • Lomitapide, >=98% (HPLC)
  • N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide
  • N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide
  • n-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)biphenyl-2-ylcarboxamido)piperidin-1-yl)butyl)-9h-fluorene-9-carboxamide
  • Lomitapide free base
  • AEGR-733(Lomitapide)
  • BMS 201238
  • BMS 201038-01
  • N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide
Show all 30 synonyms
  • 182431-12-5 (free base)
  • Lomitapide (USAN/INN)
  • AEGR-733(Lomitapide)?
  • AEGR773
  • AEGR 773

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
693.73 g/molcalc.
Exact mass
693.279 Dacalc.
LogP (octanol/water)
8.38calc.
Topological polar surface area
61.44 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
10calc.
Heavy atoms
50calc.
Rings
6calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(NC1CCN(CCCCC2c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccccc1

O=C(NC1CCN(CCCCC2c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccccc1

6 rings, 38 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Lomitapide suppliers

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All 11 suppliers
11 of 11 offers

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Where suppliers are based

11 suppliers in 5 countries

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Lomitapide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • MTP inhibitor
  • anticholesteremic drug
  • antilipemic drug
  • cardiovascular drug
  • pharmaceutical

Pharmacology

Lomitapide is a Microsomal Triglyceride Transfer Protein Inhibitor. The mechanism of action of lomitapide is as a Microsomal Triglyceride Transfer Protein Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Lomitapide is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Lomitapide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Lomitapide, based on the data on this page

What is Lomitapide?

Lomitapide is a member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide.

What is the CAS number of Lomitapide?

The CAS registry number of Lomitapide is 182431-12-5.

What is the molecular formula and weight of Lomitapide?

The molecular formula of Lomitapide is C39H37F6N3O2 and its molar mass is 693.73 g/mol.

What is Lomitapide used for?

Known uses and roles of Lomitapide include cardiovascular drugs in pharmaceuticals, mtp inhibitor, anticholesteremic drug, antilipemic drug, cardiovascular drug and 1 more.

Is Lomitapide hazardous?

No GHS hazard classification for Lomitapide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Lomitapide?

Lomitapide is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Lomitapide?

CompoundList lists 11 suppliers of Lomitapide in United States, China, Canada, Ireland and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Lomitapide?

Suppliers quote Lomitapide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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