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Alkaloids

Lycorine

Also known as Amarylline, Galanthidine, Narcissine

CAS 476-28-8Formula C16H17NO4Molar mass 287.32 g/molEC 207-503-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 11 suppliers listed
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Lycorine chemical structure, C16H17NO4, CAS 476-28-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
476-28-8
Formula
C16H17NO4
Molar mass
287.32 g/mol
EC number
207-503-6
HS code
293979
Category
Alkaloids

What is Lycorine?

Plain description, key identifiers and synonyms

Lycorine is an indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity. It has a role as an anticoronaviral agent, an antimalarial, a protein synthesis inhibitor and a plant metabolite. It derives from a hydride of a galanthan.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol
CAS number
476-28-8 CAS number cross-checked
EC number
207-503-6
Molecular formula
C16H17NO4
UNII
I9Q105R5BU
MDL number
MFCD00221746
InChIKey
XGVJWXAYKUHDOO-DANNLKNASA-N
InChI
InChI=1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2/t11-,14-,15+,16+/m0/s1
Canonical SMILES
OC1C=C2CCN3Cc4cc5c(cc4C(C1O)C23)OCO5
Isomeric SMILES
C1CN2CC3=CC4=C(C=C3[C@H]5[C@H]2C1=C[C@@H]([C@H]5O)O)OCO4

Synonyms

  • Amarylline
  • Galanthidine
  • Narcissine
  • Licorine
  • (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol
  • Lycoran-1alpha,2beta-diol, 3,3a-didehydro-
  • 9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alpha,2beta-diol
  • (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo(10.6.1.02,10.04,8.015,19)nonadeca-2,4(8),9,15-tetraene-17,18-diol
  • 2,4,5,7,12b,12C-Hexahydro-1H-(1,3)dioxolo-(4,5-J)pyrrolo(3,2,1-de)phenanthridine-1,2-diol
  • (-)-Lycorine
  • (1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol
  • (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol
  • Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-
  • Galanthan-1,2-diol, 3,12-didehydro-9,10-(methylenebis(oxy))-, (1-alpha,2-beta)-
  • Lycorine (hydrochloride)
  • 3,3a-Didehydrolycoran-1alpha,2beta-diol
  • Likorin
  • (1S,2S,12bs,12cs)-2,4,5,7,12b,12c-hexahydro-1H-(1,3)dioxolo(4,5-j)pyrrolo(3,2,1-de)phenanthridine-1,2-diol
  • 3,2beta-diol
  • Bio2_000022
  • Bio2_000502
  • LycorineGalanthidine, Narcissine, Licorine
  • 3,12-[methylenebis(oxy)]-galanthan-1alpha,2beta-diol
  • Galanthan-1, 3,12-didehydro-9,10-[methylenebis(oxy)]-, (1alpha,2beta)-
  • Galanthan-1, 3,4-didehydro-11,12-[methylenebis(oxy)]-, (1alpha,2beta)-
Show all 31 synonyms
  • (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.0?,??.0?,?.0??,??]nonadeca-2,4(8),9,15-tetraene-17,18-diol
  • (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.0^{2,10}.0^{4,8}.0^{15,19}]nonadeca-2(10),3,8,15-tetraene-17,18-diol
  • (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-Hexahydro-1H,10H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol
  • 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, (1S,2S,12bS,12cS)-
  • 2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, (1S,2S,12bS, 12cS)-
  • 2,5,7,12b,12c-Hexahydro-1H-[1,3]-dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
287.32 g/molcalc.
Exact mass
287.1158 Dacalc.
LogP (octanol/water)
0.75calc.
Topological polar surface area
62.16 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
0calc.
Heavy atoms
21calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=C2CCN3Cc4cc5c(cc4C(CC1)C23)OCO5

C1=C2CCN3Cc4cc5c(cc4C(CC1)C23)OCO5

5 rings, 19 atoms.

10 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Lycorine suppliers

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All 11 suppliers
11 of 11 offers
  • Abmole Bioscience Inc.
    United States, HoustonUnclaimed profile
    LycorineGrade, purity and minimum order on request
    Price on request
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  • Accela ChemBio Inc.
    United States, San DiegoUnclaimed profile
    LycorineGrade, purity and minimum order on request
    Price on request
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  • Acorn PharmaTech, LLC
    United States, Redwood CityUnclaimed profile
    LycorineGrade, purity and minimum order on request
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  • AvaChem Scientific LLC
    United StatesUnclaimed profile
    LycorineGrade, purity and minimum order on request
    Price on request
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  • Chemenu. Inc.
    China, ShanghaiUnclaimed profile
    LycorineGrade, purity and minimum order on request
    Price on request
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  • ChemFaces
    China, WuhanUnclaimed profile
    LycorineGrade, purity and minimum order on request
    Price on request
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  • ChemShuttle
    United States, BurlingameUnclaimed profile
    LycorineGrade, purity and minimum order on request
    Price on request
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  • Pharmacore Co., Limited
    China, KunshanUnclaimed profile
    LycorineGrade, purity and minimum order on request
    Price on request
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  • Protheragen
    United States, HolbrookUnclaimed profile
    LycorineGrade, purity and minimum order on request
    Price on request
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  • TimTec
    United States, KissimmeeUnclaimed profile
    LycorineGrade, purity and minimum order on request
    Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

11 suppliers in 2 countries

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Lycorine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • anticoronaviral agent
  • antiinfective agent
  • antimalarial
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • antiviral agent
  • enzyme inhibitor
  • eukaryotic metabolite
  • metabolite
  • pathway inhibitor
  • pharmaceutical
  • plant metabolite
  • protein synthesis inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Lycorine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Lycorine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Lycorine, based on the data on this page

What is Lycorine?

Lycorine is an indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.

What is the CAS number of Lycorine?

The CAS registry number of Lycorine is 476-28-8.

What is the molecular formula and weight of Lycorine?

The molecular formula of Lycorine is C16H17NO4 and its molar mass is 287.32 g/mol.

What is Lycorine used for?

Known uses and roles of Lycorine include anticoronaviral agent, antiinfective agent, antimalarial, antimicrobial agent, antimicrobial drug and 11 more.

Is Lycorine hazardous?

Lycorine carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Lycorine?

Lycorine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Lycorine?

CompoundList lists 11 suppliers of Lycorine in United States and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Lycorine?

Suppliers quote Lycorine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Lycorine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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