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Skin conditioning agents and actives

Madecassic acid

Also known as Brahmic acid, Oristract mda, Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2alpha,3beta,4alpha,6beta)-

CAS 18449-41-7Formula C30H48O6Molar mass 504.71 g/molEC 606-031-1
11 suppliers listed Drug substance
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Madecassic acid chemical structure, C30H48O6, CAS 18449-41-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
18449-41-7
Formula
C30H48O6
Molar mass
504.71 g/mol
EC number
606-031-1
HS code
291819
Category
Skin conditioning agents and actives

What is Madecassic acid?

Plain description, key identifiers and synonyms

Madecassic acid is a pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer). It has a role as an antioxidant, an antibacterial agent, a hypoglycemic agent, an antineoplastic agent, an apoptosis inducer and a plant metabolite. It is a monocarboxylic acid, a pentacyclic triterpenoid and a tetrol. It is a conjugate acid of a madecassate. It derives from a hydride of an ursane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
CAS number
18449-41-7 CAS number cross-checked
EC number
606-031-1
Molecular formula
C30H48O6
UNII
M7O1N24J82
MDL number
MFCD00895441, MFCD11559128
INCI name
MADECASSIC ACID
InChIKey
PRAUVHZJPXOEIF-AOLYGAPISA-N
InChI
InChI=1S/C30H48O6/c1-16-9-10-30(25(35)36)12-11-28(5)18(22(30)17(16)2)7-8-21-26(3)13-20(33)24(34)27(4,15-31)23(26)19(32)14-29(21,28)6/h7,16-17,19-24,31-34H,8-15H2,1-6H3,(H,35,36)/t16-,17+,19-,20-,21-,22+,23-,24+,26-,27+,28-,29-,30+/m1/s1
Canonical SMILES
CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC43C)C2C1C
Isomeric SMILES
C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(C[C@H]([C@@H]5[C@@]4(C[C@H]([C@@H]([C@@]5(C)CO)O)O)C)O)C)[C@@H]2[C@H]1C)C)C(=O)O

Synonyms

  • Brahmic acid
  • Oristract mda
  • Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2alpha,3beta,4alpha,6beta)-
  • 2alpha,3beta,6beta,23-Tetrahydroxyurs-12-en-28-oic Acid
  • (2alpha,3beta,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oic acid
  • Callicos CellAwake Mask madecassol
  • 6beta-hydroxyasiatic acid
  • Madecassic acid (Standard)
  • Madecassic Acid (97%)
  • (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxy-urs-12-en-28-oic acid
  • Madecassic acid (constituent of centella asiatica)
  • 2alpha,3beta,6beta,23-tetrahydroxy-urs-12-en-28-oic acid
  • Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2|A,3|A,4|A,6|A)-
  • Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-,(2alpha,3beta,4alpha,6beta)-
  • Urs-12-en-28-oic acid, 2alpha,3beta,6beta,23-tetrahydroxy-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
504.71 g/molcalc.
Exact mass
504.3451 Dacalc.
LogP (octanol/water)
4calc.
Topological polar surface area
118.2 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
36calc.
Rings
5calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.9calc.
Formal charge
0calc.
Stereocentres
13calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=C2C3CCCCC3CCC2C2CCC3CCCCC3C2C1

C1=C2C3CCCCC3CCC2C2CCC3CCCCC3C2C1

5 rings, 22 atoms.

402 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Madecassic acid suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 11 suppliers
11 of 11 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

11 suppliers in 4 countries

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Madecassic acid price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name MADECASSIC ACID(skin conditioning)

Roles

  • antibacterial agent
  • antimicrobial agent
  • antineoplastic agent
  • antioxidant
  • apoptosis inducer
  • eukaryotic metabolite
  • hypoglycemic agent
  • metabolite
  • pharmaceutical
  • plant metabolite

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Madecassic acid is traded under.

HS 2918.19Indicative HS code

Carboxylic acids with alcohol function but without other oxygen function, their…

World exports in 2024
$1.37B
+0.5% vs 2023, imports $1.18B
2019 to 2024
Top exporters
  1. China23.7%
  2. Italy14.7%
  3. India * partner reported12.0%
Top importers
  1. Germany11.7%
  2. South Korea9.8%
  3. Italy9.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Madecassic acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Madecassic acid, based on the data on this page

What is Madecassic acid?

Madecassic acid is a pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).

What is the CAS number of Madecassic acid?

The CAS registry number of Madecassic acid is 18449-41-7.

What is the molecular formula and weight of Madecassic acid?

The molecular formula of Madecassic acid is C30H48O6 and its molar mass is 504.71 g/mol.

What is Madecassic acid used for?

Known uses and roles of Madecassic acid include skin conditioning agents in cosmetics and personal care, antibacterial agent, antimicrobial agent, antineoplastic agent, antioxidant and 8 more.

Is Madecassic acid hazardous?

No GHS hazard classification for Madecassic acid is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Madecassic acid?

Madecassic acid is usually classified under HS code 291819 (Carboxylic acids with alcohol function but without other oxygen function, their…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Madecassic acid?

CompoundList lists 11 suppliers of Madecassic acid in China, India, Malaysia and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Madecassic acid in India?

1 supplier in India list Madecassic acid on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Madecassic acid?

Suppliers quote Madecassic acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Madecassic acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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