Masitinib
Also known as Masatinib, Kinavet, Kinavet CA-1
Key facts
What buyers check first
- CAS number
- 790299-79-5
- Formula
- C28H30N6OS
- Molar mass
- 498.66 g/mol
- HS code
- 293410
- Category
- Analgesics and anti-inflammatories
What is Masitinib?
Plain description, key identifiers and synonyms
Masitinib is a member of the class of benzamides that is the carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary amino group of 4-methyl-N3-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzene-1,3-diamine. It is a highly selective oral tyrosine kinase inhibitor. It has a role as an antineoplastic agent, an antirheumatic drug and a tyrosine kinase inhibitor. It is a member of benzamides, a member of pyridines, a member of 1,3-thiazoles and a N-alkylpiperazine.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide
- CAS number
- 790299-79-5 CAS number cross-checked
- Molecular formula
- C28H30N6OS
- UNII
- M59NC4E26P
- MDL number
- MFCD09954132
- InChIKey
- WJEOLQLKVOPQFV-UHFFFAOYSA-N
- InChI
- InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32)
- SMILES (canonical and isomeric)
- CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5
Synonyms
- Masatinib
- Kinavet
- Kinavet CA-1
- N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide
- 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide
- 4-((4-Methylpiperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)benzamide
- 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide
- 4-((4-Methylpiperazin-1-yl)methyl)-N-(4-methyl-3-((4-pyridin-3-yl-1,3-thiazol-2-yl)amino)phenyl)benzamide
- masitinibum
- N-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
- Masitinib (AB1010)
- Mastinib
- 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
- N-(4-Methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
- Masitinib (INN)
- 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[[4-(3-pyridyl)thiazol-2-yl]amino]phenyl]benzamide
- Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-
- Masitinib?
- N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
- Masitinib (Standard)
- Masitinib [wh
- Masican (proposed trade name)
- Sdccgsbi-0654333.p001
- US20250129067, Compound Masitinib
- 4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino) -phenyl]-benzamide
Show all 29 synonymsShow fewer synonyms
- 4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-phenyl]-benzamide
- 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2(3H)-ylidene]amino}phenyl)benzamide
- n-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
- N-[4-Methyl-3-[[4-(3-Pyridyl)-2-thiazolyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]benzamide
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 498.66 g/molcalc.Computed value |
|---|---|
| Exact mass | 498.2202 Dacalc.Computed value |
| LogP (octanol/water) | 5.26calc.Computed value |
| Topological polar surface area | 73.39 Ųcalc.Computed value |
| Hydrogen bond donors | 2calc.Computed value |
| Hydrogen bond acceptors | 7calc.Computed value |
| Rotatable bonds | 7calc.Computed value |
| Heavy atoms | 36calc.Computed value |
| Rings | 5calc.Computed value |
| Aromatic rings | 4calc.Computed value |
| Fraction sp3 carbons | 0.25calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (1 violation)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
O=C(Nc1cccc(Nc2nc(-c3cccnc3)cs2)c1)c1ccc(CN2CCNCC2)cc1
5 rings, 34 atoms.
2 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Masitinib suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- China, ChangzhouUnclaimed profileMasitinibGrade, purity and minimum order on requestPrice on request
- China, ShanghaiUnclaimed profileMasitinibGrade, purity and minimum order on requestPrice on request
- India ManufacturerUnclaimed profileMasitinibGrade, purity and minimum order on requestPrice on request
- Price on request
- China, ShanghaiUnclaimed profileMasitinibGrade, purity and minimum order on requestPrice on request
- China, Cangzhou ManufacturerUnclaimed profileMasitinibGrade, purity and minimum order on requestPrice on request
- China, GuangzhouUnclaimed profileMasitinibGrade, purity and minimum order on requestPrice on request
- United States, St. PaulUnclaimed profileMasitinibGrade, purity and minimum order on requestPrice on request
Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.
Where suppliers are based
12 suppliers in 4 countries
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Masitinib price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Industries and functions
Roles
- anti-asthmatic agent
- antimicrobial agent
- antineoplastic agent
- antipsoriatic
- antirheumatic drug
- antiviral agent
- dermatologic drug
- enzyme inhibitor
- immunomodulator
- immunosuppressive agent
- pharmaceutical
- protein kinase inhibitor
- tyrosine kinase inhibitor
Pharmacology
Masitinib is a multi-targeted protein tyrosine kinase inhibitor, with potential antineoplastic activity. Upon administration, masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit, SCFR), platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptor 3 (FGFR3), and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs).
Regulatory status
Inventories, regulations and trade controls that list this substance
No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Masitinib is traded under.
Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…
- Switzerland * partner reported36.4%
- Ireland28.8%
- China10.0%
- Canada33.4%
- United States14.4%
- Ireland13.1%
* Partner reported figures, a lower bound.
The HS code shown for Masitinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Similar structures
Nearest neighbours by Morgan fingerprint Tanimoto similarity
![4-[(4-Methyl-4-oxidopiperazin-4-ium-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide chemical structure, C29H31N7O2, CAS 571186-91-9](/s/MSADRWGPCQTOST-UHFFFAOYSA-N.svg)
Same formula isomers
Different compounds that share this molecular formula
![2-[4-(7-Methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide chemical structure, C28H30N6OS, CAS 927568-75-0](/s/QAWHHEOBNCCSJP-UHFFFAOYSA-N.svg)
![5H-Oxazolo[4,5-h][3]benzazepine, 6,7,8,9-tetrahydro-2-methyl-7-[3-[[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]- chemical structure, C28H30N6OS, CAS 871541-68-3](/s/XQYFTHHWGHOOSS-UHFFFAOYSA-N.svg)
![N'-{(E)-[4-(diethylamino)phenyl]methylidene}-2-{[5-(4-methylphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide chemical structure, C28H30N6OS, CAS 314287-90-6](/s/KHABQXHNCAXAOY-VUTHCHCSSA-N.svg)
Frequently asked questions
Quick answers about Masitinib, based on the data on this page
What is Masitinib?
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Where can I buy Masitinib in India?
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Guides for buyers
Practical guides that help when you source, ship or handle Masitinib
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Article, SourcingHow to write an RFQ that gets fast and accurate quotesWhat suppliers need to quote quickly and comparably: exact product identity, quantity and packing, delivery terms, documents, samples and payment, with a ready to use template.Read
- Guide, Trade and logisticsHS codes for chemicals and why they matterHow the Harmonized System classifies chemicals, the chapters that matter, the rules for chemically defined compounds and mixtures, and practical steps to find the right code.Read
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