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Heterocyclic compounds

Maytansine

Also known as Maitansine, Maitansina, Maytansin

CAS 35846-53-8Formula C34H46ClN3O10Molar mass 692.21 g/molEC 252-754-7
GHS signal word: Danger. Pictograms: Serious health hazard 6 suppliers listed
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Maytansine chemical structure, C34H46ClN3O10, CAS 35846-53-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
35846-53-8
Formula
C34H46ClN3O10
Molar mass
692.21 g/mol
EC number
252-754-7
HS code
293499
Category
Heterocyclic compounds

What is Maytansine?

Plain description, key identifiers and synonyms

Maytansine is an organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumour cell lines. It has a role as an antimicrobial agent, an antineoplastic agent, a tubulin modulator, an antimitotic and a plant metabolite. It is a carbamate ester, an epoxide, an organochlorine compound, an organic heterotetracyclic compound, an alpha-amino acid ester and a maytansinoid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[acetyl(methyl)amino]propanoate
CAS number
35846-53-8 CAS number cross-checked
EC number
252-754-7
Molecular formula
C34H46ClN3O10
UNII
14083FR882
MDL number
MFCD28127038
InChIKey
WKPWGQKGSOKKOO-RSFHAFMBSA-N
InChI
InChI=1S/C34H46ClN3O10/c1-18-11-10-12-26(45-9)34(43)17-25(46-32(42)36-34)19(2)30-33(5,48-30)27(47-31(41)20(3)37(6)21(4)39)16-28(40)38(7)23-14-22(13-18)15-24(44-8)29(23)35/h10-12,14-15,19-20,25-27,30,43H,13,16-17H2,1-9H3,(H,36,42)/b12-10+,18-11+/t19-,20+,25+,26-,27+,30+,33+,34+/m1/s1
Canonical SMILES
COc1cc2cc(c1Cl)N(C)C(=O)CC(OC(=O)C(C)N(C)C(C)=O)C1(C)OC1C(C)C1CC(O)(NC(=O)O1)C(OC)C=CC=C(C)C2
Isomeric SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)C)C)\C)OC)(NC(=O)O2)O

Synonyms

  • Maitansine
  • Maitansina
  • Maytansin
  • Maitansinum
  • Maysanine
  • Emtansine
  • DMMO Maytansine
  • DMMO-Maytansine
  • DM1, Maytansinoid
  • DM4, Maytansinoid
  • N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine
  • Maytansine (USAN)
  • (3beta,4beta,5beta,10beta,11e,13e)-Maytansine
  • Maytansine?
  • (4beta,5beta,11E,13E)-maytansine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
692.21 g/molcalc.
Exact mass
691.2872 Dacalc.
LogP (octanol/water)
3.53calc.
Topological polar surface area
156.5 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
5calc.
Heavy atoms
48calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.59calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2OC2CC2CC(CC=CC=CCc3cccc(c3)N1)NC(=O)O2

O=C1CCC2OC2CC2CC(CC=CC=CCc3cccc(c3)N1)NC(=O)O2

4 rings, 28 atoms.

118 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H341Suspected of causing genetic defects.
  • H361dSuspected of damaging the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Maytansine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 6 suppliers
6 of 6 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

6 suppliers in 3 countries

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Maytansine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents, Phytogenic
  • Tubulin Modulators

Roles

  • antimicrobial agent
  • antimitotic
  • antineoplastic agent
  • eukaryotic metabolite
  • metabolite
  • pharmaceutical
  • plant metabolite
  • tubulin modulator

Pharmacology

Maytansine is an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Maytansine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Maytansine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Maytansine, based on the data on this page

What is Maytansine?

Maytansine is an organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumour cell lines.

What is the CAS number of Maytansine?

The CAS registry number of Maytansine is 35846-53-8.

What is the molecular formula and weight of Maytansine?

The molecular formula of Maytansine is C34H46ClN3O10 and its molar mass is 692.21 g/mol.

What is Maytansine used for?

Known uses and roles of Maytansine include antimicrobial agent, antimitotic, antineoplastic agent, eukaryotic metabolite, metabolite and 5 more.

Is Maytansine hazardous?

Maytansine carries the GHS signal word "Danger". Main hazards: suspected of causing genetic defects, suspected of damaging the unborn child, causes damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Maytansine?

Maytansine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Maytansine?

CompoundList lists 6 suppliers of Maytansine in United States, China and Japan. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Maytansine?

Suppliers quote Maytansine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Maytansine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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