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Chlorinated and fluorinated solvents

Methoxyflurane

Also known as Methoxyfluran, Penthrane, Methoflurane

CAS 76-38-0Formula C3H4Cl2F2OMolar mass 164.97 g/molEC 200-956-0
GHS signal word: Warning. Pictograms: Flammable, Harmful or irritant, Serious health hazard 46 suppliers listed
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Methoxyflurane chemical structure, C3H4Cl2F2O, CAS 76-38-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Liquid
Melting point
-35 °C
Boiling point
105 °C
Density
Relative density (water = 1): 1.42
Flash point
63 °C
HS code
290919
Category
Chlorinated and fluorinated solvents
UN number
UN 1993
Illustrative photo, closed blue steel drums of liquid in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Methoxyflurane?

Plain description, key identifiers and synonyms

Methoxyflurane is an ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl. It has a role as a non-narcotic analgesic, an inhalation anaesthetic, a hepatotoxic agent and a nephrotoxic agent. It is an ether, an organochlorine compound and an organofluorine compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,2-dichloro-1,1-difluoro-1-methoxyethane
CAS number
76-38-0 CAS number cross-checked
EC number
200-956-0
Molecular formula
C3H4Cl2F2O
UNII
30905R8O7B
MDL number
MFCD00040144
InChIKey
RFKMCNOHBTXSMU-UHFFFAOYSA-N
InChI
InChI=1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3
SMILES (canonical and isomeric)
COC(C(Cl)Cl)(F)F

Synonyms

  • Methoxyfluran
  • Penthrane
  • Methoflurane
  • Anecotan
  • 2,2-Dichloro-1,1-difluoroethyl methyl ether
  • Metoxfluran
  • Metoxifluran
  • Analgizer
  • Inhalan
  • Metofane
  • 2,2-Dichloro-1,1-difluoro-1-methoxyethane
  • Methoxane
  • Pentrane
  • Methofane
  • Methoxiflurane
  • Methoxifluranum
  • Ingalan
  • Methoxyfluoran
  • Metoxiflurano
  • Methoxyfluorane
  • Methoxyfluranum
  • Metossiflurano
  • Ethane, 2,2-dichloro-1,1-difluoro-1-methoxy-
  • Methyl 1,1-difluoro-2,2-dichloroethyl ether
  • Penthrox
Show all 35 synonyms
  • Methoxy flurane
  • Methofluranum
  • 1,1-Difluoro-2,2-dichloroethyl methyl ether
  • Pentran
  • (2,2-dichloro-1,1-difluoroethyl) methyl ether
  • 2,2-Dichloro-1,1-difluoroethylmethylether
  • Ether, 2,2-dichloro-1,1-difluoroethyl methyl
  • Penthrane (VAN)
  • Metofane (VAN)
  • C3H4Cl2F2O

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Liquidexp.
Odour
Fruityexp.
Melting point
-35 °Cexp.
Boiling point
105 °Cexp.
Density
Relative density (water = 1): 1.42exp.
Flash point
63 °Cexp.
Solubility
In water, 28,300 mg/L at 37 °Cexp.
Vapour pressure
49 mm Hg at 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
164.97 g/molcalc.
Exact mass
163.9607 Dacalc.
LogP (octanol/water)
2.03calc.
Topological polar surface area
9.23 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
2calc.
Heavy atoms
8calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS02: Flammable
Flammable
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H226Flammable liquid and vapour.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H341Suspected of causing genetic defects.
Precautionary statements (27)
  • P203Obtain, read and follow all safety instructions before use.
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 1993

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methoxyflurane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 46 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

46 suppliers in 11 countries

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Methoxyflurane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Medication: Anesthetic.

Discontinued drug... methoxyflurane (liquid inhalation 99.9%).

Pharmacological actions

  • Anesthetics, Inhalation

Roles

  • aetiopathogenetic role
  • anaesthetic
  • analgesic
  • antineoplastic agent
  • general anaesthetic
  • hepatotoxic agent
  • inhalation anaesthetic
  • nephrotoxic agent
  • non-narcotic analgesic
  • pharmaceutical
  • vulnerary

How it is made

Produced industrially by the addition of methanol to 1,1-dichloro-2,2-difluoroethylene in the presence of sodium methoxide.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methoxyflurane is traded under.

HS 2909.19Indicative HS code

Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…

World exports in 2024
$10.2B
−8.7% vs 2023, imports $10.4B
2019 to 2024
Top exporters
  1. United States32.0%
  2. China22.3%
  3. Saudi Arabia12.9%
Top importers
  1. Singapore16.5%
  2. Mexico14.8%
  3. Japan14.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Methoxyflurane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methoxyflurane, based on the data on this page

What is Methoxyflurane?

Methoxyflurane is an ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl. It has a role as a non-narcotic analgesic, an inhalation anaesthetic, a hepatotoxic agent and a nephrotoxic agent.

What is the CAS number of Methoxyflurane?

The CAS registry number of Methoxyflurane is 76-38-0.

What is the molecular formula and weight of Methoxyflurane?

The molecular formula of Methoxyflurane is C3H4Cl2F2O and its molar mass is 164.97 g/mol.

What is Methoxyflurane used for?

Medication: Anesthetic. Discontinued drug... methoxyflurane (liquid inhalation 99.9%).

Is Methoxyflurane hazardous?

Methoxyflurane carries the GHS signal word "Warning". Main hazards: flammable liquid and vapour, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methoxyflurane?

Methoxyflurane is usually classified under HS code 290919 (Acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methoxyflurane?

CompoundList lists 46 suppliers of Methoxyflurane in United States, China, Germany, Hong Kong and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Methoxyflurane?

Suppliers quote Methoxyflurane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methoxyflurane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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