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Carboxylic acids and anhydrides

Methylmalonic acid

Also known as 2-Methylmalonic acid, 2-Methylpropanedioic acid, Isosuccinic acid

CAS 516-05-2Formula C4H6O4Molar mass 118.09 g/molEC 208-219-5
GHS signal word: Warning. Pictograms: Harmful or irritant 79 suppliers listed
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Methylmalonic acid chemical structure, C4H6O4, CAS 516-05-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
516-05-2
Formula
C4H6O4
Molar mass
118.09 g/mol
EC number
208-219-5
HS code
291719
Category
Carboxylic acids and anhydrides

What is Methylmalonic acid?

Plain description, key identifiers and synonyms

Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-methylpropanedioic acid
CAS number
516-05-2 CAS number cross-checkedOther or deprecated CAS: 1215348-94-9
EC numbers
208-219-5, 693-939-6
Molecular formula
C4H6O4
UNII
8LL8S712J7
MDL number
MFCD00002656
InChIKey
ZIYVHBGGAOATLY-UHFFFAOYSA-N
InChI
InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)
SMILES (canonical and isomeric)
CC(C(=O)O)C(=O)O

Synonyms

  • 2-Methylmalonic acid
  • 2-Methylpropanedioic acid
  • Isosuccinic acid
  • methylmalonate
  • Propanedioic acid, methyl-
  • 1,1-Ethanedicarboxylic acid
  • methylpropanedioic acid
  • Malonic acid, methyl-
  • 2-methyl-propanedioic acid
  • Acid, Methylmalonic
  • Methyl malonic acid
  • Methylpropanedioic acid, Methylmalonate
  • methylpropanedioate
  • alpha-methylmalonic acid
  • Isosuccinate
  • methyl-Malonate
  • 2-Methylmalonate
  • 2-Methylmalonicacid
  • DXX
  • methyl-Malonic acid
  • methyl-Propanedioate
  • 2-methyl-malonic acid
  • methyl-Propanedioic acid
  • 1,1-Ethanedicarboxylate
  • Methylmalonic acid, 99%
Show all 31 synonyms
  • 4-02-00-01932 (Beilstein Handbook Reference)
  • Methylmalonic acid (Standard)
  • Propanedioic acid, methyl- (9CI)
  • Propanedioic acid, 2-methyl-
  • 2-Methylmalonic acid 100 microg/mL in Acetonitrile
  • Methylmalonic acid Solution in Methanol, 1000ug/mL

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
118.09 g/molcalc.
Exact mass
118.0266 Dacalc.
LogP (octanol/water)
-0.21calc.
Topological polar surface area
74.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
8calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methylmalonic acid suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 79 suppliers
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Where suppliers are based

79 suppliers in 13 countries

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Methylmalonic acid price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methylmalonic acid is traded under.

HS 2917.19Indicative HS code

Acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and…

World exports in 2024
$718M
+8.1% vs 2023, imports $915M
2019 to 2024
Top exporters
  1. China46.6%
  2. United States13.7%
  3. Germany10.1%
Top importers
  1. United States16.2%
  2. Denmark11.8%
  3. Germany10.0%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Methylmalonic acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methylmalonic acid, based on the data on this page

What is Methylmalonic acid?

Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).

What is the CAS number of Methylmalonic acid?

The CAS registry number of Methylmalonic acid is 516-05-2. Other or deprecated CAS numbers: 1215348-94-9.

What is the molecular formula and weight of Methylmalonic acid?

The molecular formula of Methylmalonic acid is C4H6O4 and its molar mass is 118.09 g/mol.

What is Methylmalonic acid used for?

Known uses and roles of Methylmalonic acid include building blocks in research and laboratory, animal metabolite, eukaryotic metabolite, human metabolite, mammalian metabolite and 1 more.

Is Methylmalonic acid hazardous?

Methylmalonic acid carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methylmalonic acid?

Methylmalonic acid is usually classified under HS code 291719 (Acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methylmalonic acid?

CompoundList lists 79 suppliers of Methylmalonic acid in United States, China, Germany, United Kingdom and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Methylmalonic acid?

Suppliers quote Methylmalonic acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methylmalonic acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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