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Oncology and immunology drugs

Midostaurin

Also known as N-Benzoylstaurosporine, Cgp 41251, PKC 412

CAS 120685-11-2Formula C35H30N4O4Molar mass 570.65 g/molEC 848-383-0
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 74 suppliers listed Drug substance
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Midostaurin chemical structure, C35H30N4O4, CAS 120685-11-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
120685-11-2
Formula
C35H30N4O4
Molar mass
570.65 g/mol
EC number
848-383-0
HS code
293499
Category
Oncology and immunology drugs

What is Midostaurin?

Plain description, key identifiers and synonyms

Midostaurin is an organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine. It has a role as an antineoplastic agent and an EC 2.7.11.13 (protein kinase C) inhibitor. It is a member of benzamides, an organic heterooctacyclic compound, an indolocarbazole and a gamma-lactam. It is functionally related to a staurosporine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide
CAS number
120685-11-2
EC number
848-383-0
Molecular formula
C35H30N4O4
UNII
ID912S5VON
MDL number
MFCD00871372, MFCD10687105
InChIKey
BMGQWWVMWDBQGC-IIFHNQTCSA-N
InChI
InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1
Canonical SMILES
COC1C(N(C)C(=O)c2ccccc2)CC2OC1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC

Synonyms

  • N-Benzoylstaurosporine
  • Cgp 41251
  • PKC 412
  • Rydapt
  • Benzoylstaurosporine
  • midostaurina
  • midostaurine
  • Cgp 41 251
  • N-benzoyl-staurosporine
  • midostaurinum
  • 4'-N-benzoyl staurosporine
  • 4'-N-Benzoylstaurosporine
  • Midostaurin (PKC412)
  • CGP 41231
  • PKC412, CGP 41251
  • Rydapt (TN)
  • PKC412 (Midostaurin)
  • PKC-412 (Midostaurin)
  • Midostaurin (JAN/USAN/INN)
  • (Midostaurin) Benzoylstaurosporine
  • Sdccgsbi-0086703.p004
  • PKC-412, CGP-41251
  • Cgp 41251midostaurin(pkc412)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
570.65 g/molcalc.
Exact mass
570.2267 Dacalc.
LogP (octanol/water)
5.91calc.
Topological polar surface area
77.73 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
43calc.
Rings
9calc.
Aromatic rings
6calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(NC1CC2OC(C1)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O)c1ccccc1

O=C(NC1CC2OC(C1)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O)c1ccccc1

9 rings, 39 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H360May damage fertility or the unborn child.
  • H360DfMay damage the unborn child. Suspected of damaging fertility.
  • H360FDMay damage fertility. May damage the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (20)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Midostaurin suppliers

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All 74 suppliers
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Where suppliers are based

74 suppliers in 14 countries

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Midostaurin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents
  • Protein Kinase Inhibitors

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical
  • protein kinase inhibitor

Pharmacology

Midostaurin is a Kinase Inhibitor. The mechanism of action of midostaurin is as a Receptor Tyrosine Kinase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Midostaurin is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Midostaurin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Midostaurin, based on the data on this page

What is Midostaurin?

Midostaurin is an organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine. It has a role as an antineoplastic agent and an EC 2.7.11.13 (protein kinase C) inhibitor. It is a member of benzamides, an organic heterooctacyclic compound, an indolocarbazole and a gamma-lactam.

What is the CAS number of Midostaurin?

The CAS registry number of Midostaurin is 120685-11-2.

What is the molecular formula and weight of Midostaurin?

The molecular formula of Midostaurin is C35H30N4O4 and its molar mass is 570.65 g/mol.

What is Midostaurin used for?

Known uses and roles of Midostaurin include anticancer drugs in pharmaceuticals, biochemical and pharmacological tools in research and laboratory, antineoplastic agent, enzyme inhibitor, pharmaceutical and 3 more.

Is Midostaurin hazardous?

Midostaurin carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Midostaurin?

Midostaurin is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Midostaurin?

CompoundList lists 74 suppliers of Midostaurin in United States, China, India, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Midostaurin in India?

5 suppliers in India list Midostaurin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Midostaurin?

Suppliers quote Midostaurin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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