Mirabegron
Also known as Myrbetriq, Betanis, Betmiga
Key facts
What buyers check first
- CAS number
- 223673-61-8
- Formula
- C21H24N4O2S
- Molar mass
- 396.52 g/mol
- EC number
- 800-126-3
- HS code
- 293410
- Category
- Other active pharmaceutical ingredients
What is Mirabegron?
Plain description, key identifiers and synonyms
Mirabegron is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-amino-1,3-thiazol-4-ylacetic acid with the anilino group of (1R)-2-{[2-(4-aminophenyl)ethyl]amino}-1-phenylethanol. Used for the treatment of overactive bladder syndrome. It has a role as a beta-adrenergic agonist. It is a member of ethanolamines, a monocarboxylic acid amide, a member of 1,3-thiazoles and an aromatic amide.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 2-(2-amino-1,3-thiazol-4-yl)-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]acetamide
- CAS number
- 223673-61-8 CAS number cross-checked
- EC number
- 800-126-3
- Molecular formula
- C21H24N4O2S
- UNII
- MVR3JL3B2V
- MDL number
- MFCD11100356
- InChIKey
- PBAPPPCECJKMCM-IBGZPJMESA-N
- InChI
- InChI=1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1
- Canonical SMILES
- Nc1nc(CC(=O)Nc2ccc(CCNCC(O)c3ccccc3)cc2)cs1
- Isomeric SMILES
- C1=CC=C(C=C1)[C@H](CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O
Synonyms
- Myrbetriq
- Betanis
- Betmiga
- 2-(2-amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)phenyl]acetamide
- 2-(2-amino-1,3-thiazol-4-yl)-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]acetamide
- 2-(2-Aminothiazol-4-yl)-4'-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)acetanilide
- 4-Thiazoleacetamide, 2-amino-N-(4-(2-(((2R)-2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)-
- 2-(2-Amino-1,3-thiazol-4-yl)-N-(4-(2-(((2R)-2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)acetamide
- mirabegronum
- Myrbetriq granules
- 2-(2-Aminothiazol-4-yl)-N-(4-(2-(((2R)-2-hydroxy-2-phenylethyl)amino)ethyl)phenyl) Acetamide
- YM 178
- 2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
- (R)-2-(2-aminothiazol-4-yl)-N-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)acetamide
- Mirabegron (YM178)
- (R)-2-(2-aminothiazol-4-yl)-N-(4-(2-(2-hydroxy-2-phenylethylamino)ethyl)phenyl)acetamide
- Myrbetriq (TN)
- 2-(2-azanyl-1,3-thiazol-4-yl)-N-[4-[2-[[(2R)-2-oxidanyl-2-phenyl-ethyl]amino]ethyl]phenyl]ethanamide
- Mirabegron CRS
- Mirabegron (Standard)
- Mirabegron racemate CRS
- Mirabegron [EP monograph]
- Mirabegron (JAN/USAN/INN)
- 2-(2-aminothiazol-4-yl)-N-[4-[2-[[(2R)-2-hydroxy-2-phenyl-ethyl]amino]ethyl]phenyl]acetamide
- (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Show all 27 synonymsShow fewer synonyms
- (2R)-2-(2-Aminothiazol-4-yl)-4'-[2-[(2-hydrox y-2-phenylethyl)amino]ethyl]acetic acid anilide
- (R)-2-(2-Amino-4-thiazolyl)-N-[4-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]phenyl]acetamide
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 396.52 g/molcalc.Computed value |
|---|---|
| Exact mass | 396.162 Dacalc.Computed value |
| LogP (octanol/water) | 2.77calc.Computed value |
| Topological polar surface area | 100.3 ร
ยฒcalc.Computed value |
| Hydrogen bond donors | 4calc.Computed value |
| Hydrogen bond acceptors | 6calc.Computed value |
| Rotatable bonds | 9calc.Computed value |
| Heavy atoms | 28calc.Computed value |
| Rings | 3calc.Computed value |
| Aromatic rings | 3calc.Computed value |
| Fraction sp3 carbons | 0.24calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 1calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
Safety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H302Harmful if swallowed.
- H317May cause an allergic skin reaction.
- H319Causes serious eye irritation.
- H361Suspected of damaging fertility or the unborn child.
- H361dSuspected of damaging the unborn child.
- H373May cause damage to organs through prolonged or repeated exposure.
- H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (22)
- P203Obtain, read and follow all safety instructions before use.
- P260Do not breathe dust, fume, gas, mist, vapours or spray.
- P261Avoid breathing dust, fume, gas, mist, vapours or spray.
- P264Wash skin thoroughly after handling.
- P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
- P270Do not eat, drink or smoke when using this product.
- P272Contaminated work clothing should not be allowed out of the workplace.
- P273Avoid release to the environment.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P301 + P317If swallowed: Get medical help.
- P302 + P352If on skin: Wash with plenty of water.
- P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P318If exposed or concerned, get medical advice.
- P319Get medical help if you feel unwell.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P330Rinse mouth.
- P333 + P317If skin irritation or rash occurs: Get medical help.
- P337 + P317If eye irritation persists: Get medical help.
- P362 + P364Take off contaminated clothing. And wash it before reuse.
- P391Collect spillage.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidMirabegron suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- China, Zibo ManufacturerUnclaimed profileMirabegronGrade, purity and minimum order on requestPrice on request
- China, Chengdu ManufacturerUnclaimed profileMirabegronGrade, purity and minimum order on requestPrice on request
- Belgium, Mont-Saint-GuibertUnclaimed profileMirabegronGrade, purity and minimum order on requestPrice on request
- Taiwan, Taichung City ManufacturerUnclaimed profileMirabegronGrade, purity and minimum order on requestPrice on request
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- India, BengaluruUnclaimed profileMirabegronGrade, purity and minimum order on requestPrice on request
- Price on request
- China, ShanghaiUnclaimed profileMirabegronGrade, purity and minimum order on requestPrice on request
- India ManufacturerUnclaimed profileMirabegronGrade, purity and minimum order on requestPrice on request
- United StatesUnclaimed profileMirabegronGrade, purity and minimum order on requestPrice on request
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Where suppliers are based
135 suppliers in 20 countries
- China41
- India35
- United States27
- Germany4
- Canada3
- United Kingdom3
- and 14 more countries
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Mirabegron price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Pharmacological actions
- Adrenergic beta-3 Receptor Agonists
- Urological Agents
Roles
- adrenergic agent
- adrenergic agonist
- analgesic
- beta-adrenergic agonist
- beta-adrenergic drug
- cardiovascular drug
- neurotransmitter agent
- pharmaceutical
- protective agent
- renal agent
- renoprotective agent
Pharmacology
Mirabegron is a beta3-Adrenergic Agonist. The mechanism of action of mirabegron is as an Adrenergic beta3-Agonist, and Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor.
Regulatory status
Inventories, regulations and trade controls that list this substance
Health and food
- Active ingredient in FDA approved drug labels
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Mirabegron is traded under.
Compounds containing an unfused thiazole ring (whether or not hydrogenated) in theโฆ
- Switzerland * partner reported36.4%
- Ireland28.8%
- China10.0%
- Canada33.4%
- United States14.4%
- Ireland13.1%
* Partner reported figures, a lower bound.
The HS code shown for Mirabegron is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about Mirabegron, based on the data on this page
What is Mirabegron?
What is the CAS number of Mirabegron?
What is the molecular formula and weight of Mirabegron?
What is Mirabegron used for?
Is Mirabegron hazardous?
What is the HS code of Mirabegron?
Where can I buy Mirabegron?
Where can I buy Mirabegron in India?
What is the price of Mirabegron?
Guides for buyers
Practical guides that help when you source, ship or handle Mirabegron
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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