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Pharmaceuticals and APIs

Neostigmine

Also known as Eustigmin, Eustigmine, Prostigmine

CAS 59-99-4Formula C12H19N2O2+Molar mass 223.30 g/mol
38 suppliers listed Drug substance
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Neostigmine chemical structure, C12H19N2O2+, CAS 59-99-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
59-99-4
Formula
C12H19N2O2+
Molar mass
223.30 g/mol
HS code
292429
Category
Pharmaceuticals and APIs

What is Neostigmine?

Plain description, key identifiers and synonyms

Neostigmine is a quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an antidote to curare poisoning.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium
CAS number
59-99-4 CAS number cross-checked
Molecular formula
C12H19N2O2+
UNII
3982TWQ96G
InChIKey
ALWKGYPQUAPLQC-UHFFFAOYSA-N
InChI
InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1
SMILES (canonical and isomeric)
CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C

Synonyms

  • Eustigmin
  • Eustigmine
  • Prostigmine
  • Vagostigmine
  • Prostigmin
  • Neostigmin
  • Juvastigmin
  • m-Trimethylammoniumphenyldimethylcarbamate
  • 3-Trimethylammoniumphenyl N,N-dimethylcarbamate
  • Neostigmine ion
  • Neostigmine cation
  • 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium
  • Neostigmine (cation)
  • (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate
  • [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium
  • (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate (ester)
  • Ammonium, (m-hydroxyphenyl)trimethyl-, dimethylcarbamate (ester)
  • Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-
  • Prozerin
  • Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-
  • (3-(dimethylcarbamoyloxy)phenyl)-trimethylazanium
  • 3-((dimethylcarbamoyl)oxy)-N,N,N-trimethylanilinium
  • Normastigmin
  • Synstigmin
  • Neostigmine (BAN)
Show all 32 synonyms
  • Prostigmin (TN)
  • Neostigminum
  • [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium bromide
  • 3-{[(dimethylamino)carbonyl]oxy}-N,N,N-trimethylanilinium
  • [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium, sulfonatooxymethane
  • DivK1c_000165
  • DivK1c_000198

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
223.30 g/molcalc.
Exact mass
223.1441 Dacalc.
LogP (octanol/water)
1.94calc.
Topological polar surface area
29.54 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
16calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.42calc.
Formal charge
1calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Neostigmine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 38 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

38 suppliers in 14 countries

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Neostigmine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Cholinesterase Inhibitors
  • Parasympathomimetics

Roles

  • analgesic
  • anti-obesity agent
  • antidote
  • antidote to curare poisoning
  • antiglaucoma drug
  • antineoplastic agent
  • enzyme inhibitor
  • gastrointestinal drug
  • ophthalmology drug
  • pharmaceutical
  • protective agent
  • renoprotective agent

Pharmacology

Neostigmine is a Cholinesterase Inhibitor. The mechanism of action of neostigmine is as a Cholinesterase Inhibitor.

How it is made

Synthesis: aeschlimann, us patent 1,905,990 (1933 to hoffmann-la roche), yanagisawa, japan, patent 3071('51), ca 47, 4908g (1953).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Neostigmine is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Neostigmine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Neostigmine, based on the data on this page

What is Neostigmine?

Neostigmine is a quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.

What is the CAS number of Neostigmine?

The CAS registry number of Neostigmine is 59-99-4.

What is the molecular formula and weight of Neostigmine?

The molecular formula of Neostigmine is C12H19N2O2+ and its molar mass is 223.30 g/mol.

What is Neostigmine used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is Neostigmine hazardous?

No GHS hazard classification for Neostigmine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Neostigmine?

Neostigmine is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Neostigmine?

CompoundList lists 38 suppliers of Neostigmine in United States, China, India, Latvia and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Neostigmine in India?

4 suppliers in India list Neostigmine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Neostigmine?

Suppliers quote Neostigmine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Neostigmine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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