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Oncology and immunology drugs

Nilotinib

Also known as AMN 107, nilotinibum, 4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide

CAS 641571-10-0Formula C28H22F3N7OMolar mass 529.53 g/molEC 700-544-5
GHS signal word: Danger. Pictograms: Serious health hazard, Hazardous to the environment 129 suppliers listed Drug substance
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Nilotinib chemical structure, C28H22F3N7O, CAS 641571-10-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
641571-10-0
Formula
C28H22F3N7O
Appearance
White to slightly yellowish to slightly greenish yellow powder
Solubility
The solubility in aqueous solutions decreases with increasing pH
HS code
293359
Category
Oncology and immunology drugs
Illustrative photo, white powder in an open fibre drum in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Nilotinib?

Plain description, key identifiers and synonyms

Nilotinib is a secondary carboxamide, a member of imidazoles, a member of pyridines, a member of pyrimidines, a secondary amino compound and a member of (trifluoromethyl)benzenes. It has a role as an anticoronaviral agent, an antineoplastic agent and a tyrosine kinase inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
CAS number
641571-10-0 CAS number cross-checkedOther or deprecated CAS: 1353151-22-0
EC number
700-544-5
Molecular formula
C28H22F3N7O
UNII
F41401512X
MDL number
MFCD09833716
InChIKey
HHZIURLSWUIHRB-UHFFFAOYSA-N
InChI
InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
SMILES (canonical and isomeric)
CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5

Synonyms

  • AMN 107
  • nilotinibum
  • 4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide
  • Danziten
  • 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
  • 4-Methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide
  • 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide
  • Benzamide, 4-methyl-N-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(3-pyridinyl)-2-pyrimidinyl)amino)-
  • AMN 107 Base
  • benzamide, 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, hydrochloride, hydrate
  • Tasigna
  • Nilotinib (AMN-107)
  • Nilotinib free base
  • 4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide
  • 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide
  • 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
  • 4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)benzamide
  • benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-
  • 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-{(4-(pyridin-3-yl)pyrimidin-2-yl)amino}benzamide
  • 4-Methyl-N-[3-(4-methyl-1-imidazolyl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridyl)-2-pyrimidyl]amino]benzamide
  • 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide
  • Nilotinib,AMN107,Tasigna, 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide
  • Nilotinib?
  • 641571-10-0 (free base)
  • Nilotinib (Standard)
Show all 28 synonyms
  • 3gp0
  • AMN 107 Base Form
  • Nilotinib (USAN/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to slightly yellowish to slightly greenish yellow powderexp.
Solubility
The solubility in aqueous solutions decreases with increasing pHexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
529.53 g/molcalc.
Exact mass
529.1838 Dacalc.
LogP (octanol/water)
6.36calc.
Topological polar surface area
97.62 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
6calc.
Heavy atoms
39calc.
Rings
5calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.11calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1cccc(-n2ccnc2)c1)c1cccc(Nc2nccc(-c3cccnc3)n2)c1

O=C(Nc1cccc(-n2ccnc2)c1)c1cccc(Nc2nccc(-c3cccnc3)n2)c1

5 rings, 33 atoms.

27 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
  • H361fdSuspected of damaging fertility. Suspected of damaging the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (11)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nilotinib suppliers

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All 129 suppliers
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Where suppliers are based

129 suppliers in 19 countries

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Nilotinib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Tyrosine Kinase Inhibitors

Roles

  • anticoronaviral agent
  • antidyskinesia agent
  • antihypertensive agent
  • antimicrobial agent
  • antineoplastic agent
  • antiparkinson drug
  • antiviral agent
  • cardiovascular drug
  • enzyme inhibitor
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor

Pharmacology

Nilotinib is a Kinase Inhibitor. The mechanism of action of nilotinib is as a Bcr-Abl Tyrosine Kinase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2B6 Inducer, and Cytochrome P450 2C8 Inducer, and UGT1A1 Inhibitor, and P-Glycoprotein Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nilotinib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nilotinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nilotinib, based on the data on this page

What is Nilotinib?

Nilotinib is a secondary carboxamide, a member of imidazoles, a member of pyridines, a member of pyrimidines, a secondary amino compound and a member of (trifluoromethyl)benzenes. It has a role as an anticoronaviral agent, an antineoplastic agent and a tyrosine kinase inhibitor.

What is the CAS number of Nilotinib?

The CAS registry number of Nilotinib is 641571-10-0. Other or deprecated CAS numbers: 1353151-22-0.

What is the molecular formula and weight of Nilotinib?

The molecular formula of Nilotinib is C28H22F3N7O and its molar mass is 529.53 g/mol.

What is Nilotinib used for?

Known uses and roles of Nilotinib include anticancer drugs in pharmaceuticals, cns agents in pharmaceuticals, anticoronaviral agent, antidyskinesia agent, antihypertensive agent and 10 more.

Is Nilotinib hazardous?

Nilotinib carries the GHS signal word "Danger". Main hazards: suspected of damaging fertility or the unborn child, suspected of damaging fertility. suspected of damaging the unborn child, causes damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nilotinib?

Nilotinib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nilotinib?

CompoundList lists 129 suppliers of Nilotinib in China, United States, India, United Kingdom and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Nilotinib in India?

9 suppliers in India list Nilotinib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Nilotinib?

Suppliers quote Nilotinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nilotinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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