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Analgesics and anti-inflammatories

Nimesulide

Also known as N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide, Aulin, Nimesulida

CAS 51803-78-2Formula C13H12N2O5SMolar mass 308.32 g/molEC 257-431-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 143 suppliers listed
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Nimesulide chemical structure, C13H12N2O5S, CAS 51803-78-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
51803-78-2
Formula
C13H12N2O5S
Molar mass
308.32 g/mol
EC number
257-431-4
HS code
293590
Category
Analgesics and anti-inflammatories

What is Nimesulide?

Plain description, key identifiers and synonyms

Nimesulide is an aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups. It has a role as a non-steroidal anti-inflammatory drug and a cyclooxygenase 2 inhibitor. It is a sulfonamide, an aromatic ether and a C-nitro compound. It is functionally related to a nitrobenzene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(4-nitro-2-phenoxyphenyl)methanesulfonamide
CAS number
51803-78-2 CAS number cross-checkedOther or deprecated CAS: 1364966-82-4
EC number
257-431-4
Molecular formula
C13H12N2O5S
UNII
V4TKW1454M
MDL number
MFCD00079470
InChIKey
HYWYRSMBCFDLJT-UHFFFAOYSA-N
InChI
InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
SMILES (canonical and isomeric)
CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2

Synonyms

  • N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
  • Aulin
  • Nimesulida
  • 4-Nitro-2-phenoxymethanesulfonanilide
  • Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)-
  • Nimesulidum
  • 4'-Nitro-2'-phenoxymethanesulfonanilide
  • N-(4-nitro-2-(phenoxy)phenyl)methanesulfonamide
  • N-[4-nitro-2-(phenoxy)phenyl]methanesulfonamide
  • Mesulid
  • Flogovital
  • Sulidene
  • Nimed
  • Nisulid
  • 4-Nitro-2-phenoxy-methanesulfonanilide
  • Methanesulfonanilide, 4'-nitro-2'-phenoxy-
  • n-(4-nitro-2-phenoxyphenyl)methanesulphonamide
  • N-[4-Nitro-2-phenoxyphenyl]-methanesulfonamide
  • Antifloxil
  • Guaxan
  • NIM
  • 4'-Nitro-2'-phenoxymethansulfonanilid
  • Aldoron
  • Nimedex
  • Orthobid
Show all 30 synonyms
  • Nimesulide CRS
  • Nise Gel
  • Nimesulide (Standard)
  • Nimesulide (JAN/INN)
  • N-(4-nitro-2-phenoxy-phenyl)methanesulfonamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
308.32 g/molcalc.
Exact mass
308.0467 Dacalc.
LogP (octanol/water)
2.76calc.
Topological polar surface area
98.54 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
5calc.
Heavy atoms
21calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.08calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Oc2ccccc2)cc1

c1ccc(Oc2ccccc2)cc1

2 rings, 13 atoms, the Diphenyl ether ring system.

9,579 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nimesulide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 143 suppliers
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Where suppliers are based

143 suppliers in 24 countries

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Nimesulide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase Inhibitors

Roles

  • analgesic
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antineoplastic agent
  • antirheumatic drug
  • cyclooxygenase 2 inhibitor
  • enzyme inhibitor
  • non-steroidal anti-inflammatory drug
  • pharmaceutical

Pharmacology

Nimesulide is a nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nimesulide is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nimesulide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nimesulide, based on the data on this page

What is Nimesulide?

Nimesulide is an aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups. It has a role as a non-steroidal anti-inflammatory drug and a cyclooxygenase 2 inhibitor. It is a sulfonamide, an aromatic ether and a C-nitro compound. It is functionally related to a nitrobenzene.

What is the CAS number of Nimesulide?

The CAS registry number of Nimesulide is 51803-78-2. Other or deprecated CAS numbers: 1364966-82-4.

What is the molecular formula and weight of Nimesulide?

The molecular formula of Nimesulide is C13H12N2O5S and its molar mass is 308.32 g/mol.

What is Nimesulide used for?

Use classes: Pharmaceuticals.

Is Nimesulide hazardous?

Nimesulide carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nimesulide?

Nimesulide is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nimesulide?

CompoundList lists 143 suppliers of Nimesulide in India, United States, China, United Kingdom and 20 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Nimesulide in India?

43 suppliers in India list Nimesulide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Nimesulide?

Suppliers quote Nimesulide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nimesulide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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