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Alkaloids

Noscapine

Also known as Narcotine, Tusscapine, Methoxyhydrastine

CAS 128-62-1Formula C22H23NO7Molar mass 413.43 g/molEC 204-899-2
GHS signal word: Warning. Pictograms: Harmful or irritant 37 suppliers listed
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Noscapine chemical structure, C22H23NO7, CAS 128-62-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Orthorhombic bisphenoidal prisms
Melting point
176 °C
Density
1.395
Solubility
FINE, WHITE, OR PRACTICALLY WHITE, CRYSTALLINE POWDER, ODORLESS OR HAS SLIGHT ODOR OF ET…
HS code
293919
Category
Alkaloids
Illustrative photo, closed blue fibre drums on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Noscapine?

Plain description, key identifiers and synonyms

(-)-noscapine is a benzylisoquinoline alkaloid that is 1,2,3,4-tetrahydroisoquinoline which is substituted by a 4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl group at position 1, a methylenedioxy group at positions 6-7 and a methoxy group at position 8. Obtained from plants of the Papaveraceae family, it lacks significant painkilling properties and is primarily used for its antitussive (cough-suppressing) effects. It has a role as an antineoplastic agent, an antitussive, an apoptosis inducer and a plant metabolite. It is a benzylisoquinoline alkaloid, an organic heterotricyclic compound, an organic heterobicyclic compound, an aromatic ether, a tertiary amino compound, an isobenzofuranone and a cyclic acetal. It is functionally related to a (-)-noscapine hemiacetal.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one
CAS number
128-62-1 CAS number cross-checkedOther or deprecated CAS: 6035-40-1
EC number
204-899-2
Molecular formula
C22H23NO7
UNII
8V32U4AOQU, A4C6WE7BZN
MDL number
MFCD00069316
InChIKey
AKNNEGZIBPJZJG-MSOLQXFVSA-N
InChI
InChI=1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1
Canonical SMILES
COc1ccc2c(c1OC)C(=O)OC2C1c2c(cc3c(c2OC)OCO3)CCN1C
Isomeric SMILES
CN1CCC2=CC3=C(C(=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3

Synonyms

  • Narcotine
  • Tusscapine
  • Methoxyhydrastine
  • Terbenol
  • Coscopin
  • Narcompren
  • Narcosine
  • Vadebex
  • Noscapalin
  • Longatin
  • Opianine
  • (-)-Narcotine
  • Narcotin
  • Narcotussin
  • Nectadon
  • Nicolane
  • Noscapin
  • Lyobex
  • Nipaxon
  • Opianin
  • Opian
  • Coscotabs
  • alpha-Narcotine
  • Key-tusscapine
  • Noscapinum
Show all 38 synonyms
  • O-Methylnarcotoline
  • (-)-alpha-narcotine
  • Narcotinum
  • (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-1,3-dihydro-2-benzofuran-1-one
  • (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one
  • 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)-isoquinolin-5-yl), (S-(R*,S*))-
  • Tropfen, Capval
  • (3S)-6,7-dimethoxy-3-((5R)-4-methoxy-6-methyl-2H,5H,6H,7H,8H-(1,3)dioxolo(4,5-g)isoquinolin-5-yl)-1,3-dihydro-2-benzofuran-1-one
  • (3S)-6,7-dimethoxy-3-((5R)-4-methoxy-6-methyl-7,8-dihydro-5H-(1,3)dioxolo(4,5-g)isoquinolin-5-yl)-3H-2-benzofuran-1-one
  • noscapin hydrochloride
  • prikkelhoest, Librochin
  • Hydrochloride, Noscapine
  • camphoscapine (camsilate)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Orthorhombic bisphenoidal prismsexp.
Odour
ODORLESSexp.
Taste
VERY BITTER TASTEexp.
Melting point
176 °Cexp.
Density
1.395exp.
Solubility
FINE, WHITE, OR PRACTICALLY WHITE, CRYSTALLINE POWDER, ODORLESS OR HAS SLIGHT ODOR OF ETHANOL, FREELY SOL IN CHLOROFORM & METHANOL, SOL IN ALCOHOL, SPARINGLY SOL IN ACETONE, PRACTICALLY INSOL IN ETHER, SOLN IN WATER IS DEXTROROTATORY, PH…exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
413.43 g/molcalc.
Exact mass
413.1475 Dacalc.
LogP (octanol/water)
2.88calc.
Topological polar surface area
75.69 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
4calc.
Heavy atoms
30calc.
Rings
5calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.41calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1OC(C2NCCc3cc4c(cc32)OCO4)c2ccccc21

O=C1OC(C2NCCc3cc4c(cc32)OCO4)c2ccccc21

5 rings, 23 atoms.

40 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Noscapine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 37 suppliers
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Where suppliers are based

37 suppliers in 13 countries

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Noscapine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antitussive Agents

Roles

  • antineoplastic agent
  • antitussive
  • apoptosis inducer
  • eukaryotic metabolite
  • metabolite
  • pharmaceutical
  • plant metabolite

Pharmacology

Noscapine is a phthalide isoquinoline non-narcotic alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine exerts its antitussive effects through the activation of sigma opioid receptors. This agent appears to exert its antimitotic effect by binding to tubulin, resulting in a disruption of microtubule assembly dynamics and subsequently, the inhibition of mitosis and tumor cell death.

How it is made

Maillard, us patent 3,108,106 (1963 to jacques logeais).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Noscapine (INN) and its salts, Ref no: 258, Annex ref: II/258

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Noscapine is traded under.

HS 2939.19Indicative HS code

Alkaloids of opium and their derivatives, salts thereof, other

World exports in 2024
$239M
+42.2% vs 2023, imports $256M
2019 to 2024
Top exporters
  1. United States19.1%
  2. Hungary17.1%
  3. India * partner reported15.8%
Top importers
  1. United States19.6%
  2. India * partner reported17.4%
  3. Canada9.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Noscapine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Noscapine, based on the data on this page

What is Noscapine?

(-)-noscapine is a benzylisoquinoline alkaloid that is 1,2,3,4-tetrahydroisoquinoline which is substituted by a 4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl group at position 1, a methylenedioxy group at positions 6-7 and a methoxy group at position 8.

What is the CAS number of Noscapine?

The CAS registry number of Noscapine is 128-62-1. Other or deprecated CAS numbers: 6035-40-1.

What is the molecular formula and weight of Noscapine?

The molecular formula of Noscapine is C22H23NO7 and its molar mass is 413.43 g/mol.

What is Noscapine used for?

Use classes: Pharmaceuticals.

Is Noscapine hazardous?

Noscapine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Noscapine?

Noscapine is usually classified under HS code 293919 (Alkaloids of opium and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Noscapine?

CompoundList lists 37 suppliers of Noscapine in United States, China, India, Iran and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Noscapine in India?

6 suppliers in India list Noscapine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Noscapine?

Suppliers quote Noscapine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Noscapine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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