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Antibiotics and anti-infectives

Oltipraz

Also known as 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione, Oltiprazum, RP 35972

CAS 64224-21-1Formula C8H6N2S3Molar mass 226.35 g/molEC 264-736-6
GHS signal word: Warning. Pictograms: Harmful or irritant 31 suppliers listed
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Oltipraz chemical structure, C8H6N2S3, CAS 64224-21-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
64224-21-1
Formula
C8H6N2S3
Molar mass
226.35 g/mol
EC number
264-736-6
HS code
293499
Category
Antibiotics and anti-infectives

What is Oltipraz?

Plain description, key identifiers and synonyms

Oltipraz is a 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively. It has a role as an antioxidant, an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, an antineoplastic agent, a schistosomicide drug, a protective agent, a neurotoxin, an angiogenesis modulating agent and an antimutagen. It is a member of pyrazines and a 1,2-dithiole.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-methyl-5-pyrazin-2-yldithiole-3-thione
CAS number
64224-21-1 CAS number cross-checked
EC number
264-736-6
Molecular formula
C8H6N2S3
UNII
6N510JUL1Y
MDL number
MFCD00868499
InChIKey
CKNAQFVBEHDJQV-UHFFFAOYSA-N
InChI
InChI=1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
SMILES (canonical and isomeric)
CC1=C(SSC1=S)C2=NC=CN=C2

Synonyms

  • 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione
  • Oltiprazum
  • RP 35972
  • 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
  • RP-35,972
  • 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-
  • 5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione
  • 4-Methyl-5-(pyrazinyl)-3H-1,2-dithiole-3-thione
  • 4-methyl-PDT
  • 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione
  • 5-(2-Pyrazinyl)-4-methyl-1,2-3-thione
  • 3H-1,2-Dithiole-3-thione,4-methyl-5-pyrazinyl
  • 4-methyl-5-pyrazin-2-yldithiole-3-thione
  • 4-methyl-5-pyrazin-2-yl-dithiole-3-thione
  • RP 35972, NSC 347901
  • Oltipraz?
  • Oltipraz (GMP)
  • 4-methyl-5-pyrazin-2-yl-3H-1,2-dithiole-3-thione
  • 3H-1, 4-methyl-5-pyrazinyl-
  • Oltipraz, >=98% (HPLC), powder
  • 3H-1,2-Dithiole-3-thione, 4-methyl-5-(2-pyrazinyl)-
  • OLT

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
226.35 g/molcalc.
Exact mass
225.9693 Dacalc.
LogP (octanol/water)
3.3calc.
Topological polar surface area
25.78 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
13calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, S=c1cc(-c2cnccn2)ss1

S=c1cc(-c2cnccn2)ss1

2 rings, 12 atoms, the 5-Pyrazin-2-yldithiole-3-thione ring system.

7 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Oltipraz suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 31 suppliers
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Where suppliers are based

31 suppliers in 7 countries

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Oltipraz price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Anticarcinogenic Agents
  • Antiviral Agents
  • Reverse Transcriptase Inhibitors
  • Schistosomicides

Roles

  • aetiopathogenetic role
  • angiogenesis modulating agent
  • anthelminthic drug
  • antiinfective agent
  • antimutagen
  • antineoplastic agent
  • antioxidant
  • antiparasitic agent
  • antiplatyhelmintic drug
  • enzyme inhibitor
  • hepatoprotective agent
  • neurotoxin
  • pharmaceutical
  • poison
  • protective agent
  • schistosomicide drug

Pharmacology

Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Oltipraz is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Oltipraz is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Oltipraz, based on the data on this page

What is Oltipraz?

Oltipraz is a 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.

What is the CAS number of Oltipraz?

The CAS registry number of Oltipraz is 64224-21-1.

What is the molecular formula and weight of Oltipraz?

The molecular formula of Oltipraz is C8H6N2S3 and its molar mass is 226.35 g/mol.

What is Oltipraz used for?

Known uses and roles of Oltipraz include antivirals in pharmaceuticals, aetiopathogenetic role, angiogenesis modulating agent, anthelminthic drug, antiinfective agent and 16 more.

Is Oltipraz hazardous?

Oltipraz carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Oltipraz?

Oltipraz is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Oltipraz?

CompoundList lists 31 suppliers of Oltipraz in China, United States, Canada, Germany and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Oltipraz?

Suppliers quote Oltipraz on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Oltipraz

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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