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Respiratory, allergy and digestive drugs

Oxymetazoline

Also known as Oxymethazoline, Hazol, Oximetazolinum

CAS 1491-59-4Formula C16H24N2OMolar mass 260.38 g/molEC 216-079-1
GHS signal word: Danger. Pictograms: Corrosive, Acute toxicity (severe) 51 suppliers listed Drug substance
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Oxymetazoline chemical structure, C16H24N2O, CAS 1491-59-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from benzene
Melting point
181 to 183
Solubility
Mol wt 296.84. Crystals, dec 300-303 °C. Freely sol in water, alcohol. Practically insol…
HS code
293329
Category
Respiratory, allergy and digestive drugs
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Oxymetazoline?

Plain description, key identifiers and synonyms

Oxymetazoline is a member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion. It has a role as a sympathomimetic agent, an alpha-adrenergic agonist, a vasoconstrictor agent and a nasal decongestant. It is a member of phenols, a carboxamidine and a member of imidazolines. It is a conjugate base of an oxymetazoline(1+).

Oxymetazoline is a topical decongestant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
CAS number
1491-59-4 CAS number cross-checked
EC number
216-079-1
Molecular formula
C16H24N2O
UNII
8VLN5B44ZY
MDL number
MFCD00242798
InChIKey
WYWIFABBXFUGLM-UHFFFAOYSA-N
InChI
InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)
SMILES (canonical and isomeric)
CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C

Synonyms

  • Oxymethazoline
  • Hazol
  • Oximetazolinum
  • Oxylazine
  • Rhinofrenol
  • Sinerol
  • Iliadin
  • Navisin
  • Nezeril
  • Nafrine
  • Oxymetozoline
  • Oximetazolina
  • Oxymetazolinum
  • Afrin
  • 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
  • Nasacon
  • Operil
  • 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol
  • 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline
  • Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-
  • 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol
  • 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol
  • Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-
  • Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-
  • Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-
Show all 34 synonyms
  • 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethylphenol
  • Sinufrin Quick Relief Decongestant
  • Rhinolitan
  • Oxymetazoline (INN)
  • Navasin
  • 6-tert-Butyl-3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,4-dimethylphenol
  • Operil (TN)
  • oxymetazoline hydrochloride crystalline
  • oxymetazolina

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from benzeneexp.
Melting point
181 to 183exp.
Solubility
Mol wt 296.84. Crystals, dec 300-303 °C. Freely sol in water, alcohol. Practically insol in ether, chloroform, benzene /Hydrochloride/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
260.38 g/molcalc.
Exact mass
260.1889 Dacalc.
LogP (octanol/water)
2.85calc.
Topological polar surface area
44.62 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CC2=NCCN2)cc1

c1ccc(CC2=NCCN2)cc1

2 rings, 12 atoms, the Tolazoline ring system.

79 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300 + H330Fatal if swallowed. Fatal if inhaled.
  • H300Fatal if swallowed.
  • H318Causes serious eye damage.
  • H330Fatal if inhaled.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (19)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Oxymetazoline suppliers

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All 51 suppliers
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Where suppliers are based

51 suppliers in 16 countries

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Oxymetazoline price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Adrenergic (vasoconstrictor), nasal decongestant.

Oxymetazoline nasal spray is a potent /alpha 2/-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adrenergic alpha-Agonists
  • Nasal Decongestants
  • Sympathomimetics

Roles

  • adrenergic agent
  • adrenergic agonist
  • alpha-adrenergic agonist
  • alpha-adrenergic drug
  • cardiovascular drug
  • nasal decongestant
  • neurotransmitter agent
  • ophthalmology drug
  • pharmaceutical
  • sympathomimetic agent
  • vasoconstrictor agent

Pharmacology

Oxymetazoline is a Vasoconstrictor. The physiologic effect of oxymetazoline is by means of Vasoconstriction and Increased Sympathetic Activity.

How it is made

From (4-tert-butyl-2,6-dimethyl-3-hydroxyphenyl)acetonitrile & ethylenediamine: FRUHSTORFER, MUELLER-CALGAN...CHEM ABST 57, 4674A (1962).

6-t-Butyl-2,4-dimethylphenol + formaldehyde + sodium cyanide + ethylenediamine (chloromethylation/cyanidation/condensation)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Oxymetazoline is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Oxymetazoline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Oxymetazoline, based on the data on this page

What is Oxymetazoline?

Oxymetazoline is a member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively.

What is the CAS number of Oxymetazoline?

The CAS registry number of Oxymetazoline is 1491-59-4.

What is the molecular formula and weight of Oxymetazoline?

The molecular formula of Oxymetazoline is C16H24N2O and its molar mass is 260.38 g/mol.

What is Oxymetazoline used for?

Therapeutic category: Adrenergic (vasoconstrictor), nasal decongestant. Oxymetazoline nasal spray is a potent /alpha 2/-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa. Use classes: Pharmaceuticals.

Is Oxymetazoline hazardous?

Oxymetazoline carries the GHS signal word "Danger". Main hazards: fatal if swallowed. fatal if inhaled, fatal if swallowed, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Oxymetazoline?

Oxymetazoline is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Oxymetazoline?

CompoundList lists 51 suppliers of Oxymetazoline in United States, China, India, Spain and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Oxymetazoline in India?

4 suppliers in India list Oxymetazoline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Oxymetazoline?

Suppliers quote Oxymetazoline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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