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Analgesics and anti-inflammatories

Palmitoylethanolamide

Also known as Palmidrol, N-(2-Hydroxyethyl)hexadecanamide, Palmitoyl ethanolamide

CAS 544-31-0Formula C18H37NO2Molar mass 299.50 g/molEC 208-867-9
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant, Hazardous to the environment 103 suppliers listed
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Palmitoylethanolamide chemical structure, C18H37NO2, CAS 544-31-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
544-31-0
Formula
C18H37NO2
Molar mass
299.50 g/mol
Physical form
Solid
HS code
292419
Category
Analgesics and anti-inflammatories
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Palmitoylethanolamide?

Plain description, key identifiers and synonyms

Palmitoyl ethanolamide is an N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid. It has a role as an anti-inflammatory drug, an anticonvulsant, an antihypertensive agent and a neuroprotective agent. It is a N-(long-chain-acyl)ethanolamine, an endocannabinoid and a N-(saturated fatty acyl)ethanolamine. It is functionally related to a hexadecanoic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(2-hydroxyethyl)hexadecanamide
CAS number
544-31-0 CAS number cross-checked
EC number
208-867-9
Molecular formula
C18H37NO2
UNII
6R8T1UDM3V
MDL number
MFCD00020562
INCI name
PALMITAMIDE MEA
InChIKey
HXYVTAGFYLMHSO-UHFFFAOYSA-N
InChI
InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)
SMILES (canonical and isomeric)
CCCCCCCCCCCCCCCC(=O)NCCO

Synonyms

  • Palmidrol
  • N-(2-Hydroxyethyl)hexadecanamide
  • Palmitoyl ethanolamide
  • Palmitic acid monoethanolamide
  • Hydroxyethylpalmitamide
  • Loramine P 256
  • palmitylethanolamide
  • Palmidrolum
  • Levagen
  • Palmdrol prodes
  • Monoethanolamine palmitic acid amide
  • palmitic monoethanolamide
  • Palmitinsaeure-beta-hydroxyethylamid
  • Anandamide (16:0)
  • hexadecanoyl ethanolamide
  • N(2-hydroxyethyl)palmitide
  • N(2-hydroxyethyl) palmitide
  • N-(2-hydroxyethyl)-palmitide
  • n-palmitoyl ethanolamide
  • AM 3112
  • SCI-110 component palmitoylethanolamide
  • n-palmitoylethanolamide
  • N-(2-hydroxyethyl)palmitate
  • OptiPEA
  • N-(2-Hydroxyethyl)palmitamide
Show all 37 synonyms
  • Palmitamide MEA
  • Impulsin
  • N-palmitoylethanolamine
  • Palmitoyl-EA
  • Hexadecanamide, N-(2-hydroxyethyl)-
  • N-hexadecanoylethanolamine
  • PEA (Chemical)
  • N-hexadecanoyl-ethanolamine
  • Palmidrol (INN)
  • NAE 16:0
  • Palmitoylethanolamid?e
  • AM 3112, Loramine P 256, Mackpeart DR 14V

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Solidexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
299.50 g/molcalc.
Exact mass
299.2824 Dacalc.
LogP (octanol/water)
4.58calc.
Topological polar surface area
49.33 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
16calc.
Heavy atoms
21calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.94calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H411Toxic to aquatic life with long lasting effects.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (12)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Palmitoylethanolamide suppliers

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All 103 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

103 suppliers in 14 countries

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Palmitoylethanolamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industrial uses: Surfactant (surface active agent).

Consumer uses: Surfactant (surface active agent).

Use classes: Cosmetics.

Cosmetic ingredient, INCI name PALMITAMIDE MEA(antistatic, surfactant - foam boosting, viscosity controlling)

Pharmacological actions

  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antiviral Agents
  • Cannabinoid Receptor Agonists

Roles

  • analgesic
  • anti-inflammatory agent
  • anti-inflammatory drug
  • anticonvulsant
  • antihypertensive agent
  • antimicrobial agent
  • antipsychotic agent
  • antiviral agent
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • psychotropic drug
  • tranquilizing drug

Functional uses

  • Anti-static agent
  • Foamant
  • Viscosity modifier

Cosmetic functions

  • Antistatic
  • Surfactant - foam boosting
  • Viscosity controlling

Pharmacology

Palmidrol is a natural fatty acid amide that is both a food component and an endogenously synthesized compound, with potential analgesic and anti-inflammatory activities. Upon administration, palmidrol may inhibit the release of pro-inflammatory mediators from activated mast cells. This may reduce inflammation and pain.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Palmitoylethanolamide is traded under.

HS 2924.19Indicative HS code

Acyclic amides (including acyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$2.38B
−1.7% vs 2023, imports $2.22B
2019 to 2024
Top exporters
  1. China34.7%
  2. Germany12.5%
  3. India * partner reported6.8%
Top importers
  1. United States17.5%
  2. Germany8.8%
  3. India * partner reported6.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Palmitoylethanolamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Palmitoylethanolamide, based on the data on this page

What is Palmitoylethanolamide?

Palmitoyl ethanolamide is an N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid. It has a role as an anti-inflammatory drug, an anticonvulsant, an antihypertensive agent and a neuroprotective agent.

What is the CAS number of Palmitoylethanolamide?

The CAS registry number of Palmitoylethanolamide is 544-31-0.

What is the molecular formula and weight of Palmitoylethanolamide?

The molecular formula of Palmitoylethanolamide is C18H37NO2 and its molar mass is 299.50 g/mol.

What is Palmitoylethanolamide used for?

Industrial uses: Surfactant (surface active agent). Consumer uses: Surfactant (surface active agent). Use classes: Cosmetics.

Is Palmitoylethanolamide hazardous?

Palmitoylethanolamide carries the GHS signal word "Danger". Main hazards: causes skin irritation, causes serious eye damage, toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Palmitoylethanolamide?

Palmitoylethanolamide is usually classified under HS code 292419 (Acyclic amides (including acyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Palmitoylethanolamide?

CompoundList lists 103 suppliers of Palmitoylethanolamide in China, United States, India, United Kingdom and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Palmitoylethanolamide in India?

7 suppliers in India list Palmitoylethanolamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Palmitoylethanolamide?

Suppliers quote Palmitoylethanolamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Palmitoylethanolamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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