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Antibiotics and anti-infectives

Penciclovir

Also known as Denavir, Penciclovirum, Vectavir

CAS 39809-25-1Formula C10H15N5O3Molar mass 253.26 g/molEC 663-371-3
GHS signal word: Warning. Pictograms: Harmful or irritant 101 suppliers listed Drug substance
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Penciclovir chemical structure, C10H15N5O3, CAS 39809-25-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White crystalline solid from water (monohydrate) also reported as colorless matted needles
Melting point
275 to 277
Solubility
Occurs as monohydrate, stable crystalline solid. Solubility in water (20 °C): >200 mg/mL…
HS code
293359
Category
Antibiotics and anti-infectives
Illustrative photo, colourless crystals in an open woven sack in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Penciclovir?

Plain description, key identifiers and synonyms

Penciclovir is a member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration. It has a role as an antiviral drug. It is a member of 2-aminopurines and a member of propane-1,3-diols. It is functionally related to a guanine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1H-purin-6-one
CAS number
39809-25-1 CAS number cross-checked
EC number
663-371-3
Molecular formula
C10H15N5O3
UNII
359HUE8FJC
MDL number
MFCD00866931, MFCD15142866
InChIKey
JNTOCHDNEULJHD-UHFFFAOYSA-N
InChI
InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
SMILES (canonical and isomeric)
C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N

Synonyms

  • Denavir
  • Penciclovirum
  • Vectavir
  • BRL 39123
  • 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
  • 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine
  • 9-(4-Hydroxy-3-(hydroxymethyl)but-1-yl)guanine
  • 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine
  • 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine
  • 9-[4-Hydroxy-3-(hydroxymethyl)butyl]guanine
  • 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine
  • 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-
  • 9-[2-hydroxy-1-(hydroxymethyl)-ethoxymethyl]guanine
  • 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-
  • 2-Amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one
  • 9-(2-hydroxy-1-(hydroxymethyl)-ethoxymethyl)guanine
  • 2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6,9-dihydro-3H-purin-6-one
  • 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6,9-dihydro-3H-purin-6-one
  • Pencyclovir
  • 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin-6-one
  • 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1H-purin-6-one
  • 2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-purin-6(9H)-one
  • Famciclovir Penciclovir Impurity (Usp)
  • 2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-1,9-dihydro-6H-purin-6-one
  • 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1,9-dihydro-6H-purin-6-one
Show all 33 synonyms
  • 2-amino-9-[1,1,2,2-tetradeuterio-4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin-6-one
  • PCV
  • Adenovir
  • Denavir (TN)
  • Penciclovir (USAN/INN)
  • Penciclovir?
  • 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one, Denavir, Penciclovir, VSA 671,
  • Penciclovir (Standard)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White crystalline solid from water (monohydrate) also reported as colorless matted needlesexp.
Melting point
275 to 277exp.
Solubility
Occurs as monohydrate, stable crystalline solid. Solubility in water (20 °C): >200 mg/mL, 30 mg/mL solution has pH 11/Penciclovir sodium salt/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
253.26 g/molcalc.
Exact mass
253.1175 Dacalc.
LogP (octanol/water)
-1.31calc.
Topological polar surface area
130.1 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]cnc2nc[nH]c12

O=c1[nH]cnc2nc[nH]c12

2 rings, 10 atoms, the Hypoxanthine ring system.

586 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H319Causes serious eye irritation.
Precautionary statements (4)
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P337 + P317If eye irritation persists: Get medical help.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Penciclovir suppliers

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All 101 suppliers
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Where suppliers are based

101 suppliers in 16 countries

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Penciclovir price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Viral DNA polymerase inhibitor.

Therapeutic category: Antiviral.

Industries and functions

Pharmacological actions

  • Antiviral Agents

Roles

  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antiviral agent
  • antiviral drug
  • pharmaceutical

Pharmacology

Penciclovir is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. The mechanism of action of penciclovir is as a DNA Polymerase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Penciclovir is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Penciclovir is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Penciclovir, based on the data on this page

What is Penciclovir?

Penciclovir is a member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.

What is the CAS number of Penciclovir?

The CAS registry number of Penciclovir is 39809-25-1.

What is the molecular formula and weight of Penciclovir?

The molecular formula of Penciclovir is C10H15N5O3 and its molar mass is 253.26 g/mol.

What is Penciclovir used for?

Viral DNA polymerase inhibitor. Therapeutic category: Antiviral.

Is Penciclovir hazardous?

Penciclovir carries the GHS signal word "Warning". Main hazards: causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Penciclovir?

Penciclovir is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Penciclovir?

CompoundList lists 101 suppliers of Penciclovir in United States, China, United Kingdom, India and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Penciclovir in India?

6 suppliers in India list Penciclovir on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Penciclovir?

Suppliers quote Penciclovir on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Penciclovir

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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