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Cardiovascular and metabolic drugs

Phenoxybenzamine

Also known as Dibenylin, Bensylyt, Dibenyline

CAS 59-96-1Formula C18H22ClNOMolar mass 303.83 g/molEC 200-446-8
32 suppliers listed Drug substance
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Phenoxybenzamine chemical structure, C18H22ClNO, CAS 59-96-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from petroleum ether
Melting point
137.5 to 140 °C
Solubility
WHITE CRYSTALLINE POWDER, SOL IN 9 PARTS CHLOROFORM, INSOL IN DIETHYLETHER /PHENOXYBENZA…
HS code
292229
Category
Cardiovascular and metabolic drugs
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Phenoxybenzamine?

Plain description, key identifiers and synonyms

Phenoxybenzamine is an aromatic amine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine
CAS number
59-96-1 CAS number cross-checkedOther or deprecated CAS: 102737-84-8
EC number
200-446-8
Molecular formula
C18H22ClNO
UNII
0TTZ664R7Z
InChIKey
QZVCTJOXCFMACW-UHFFFAOYSA-N
InChI
InChI=1S/C18H22ClNO/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17/h2-11,16H,12-15H2,1H3
SMILES (canonical and isomeric)
CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2

Synonyms

  • Dibenylin
  • Bensylyt
  • Dibenyline
  • Benzylyt
  • Fenoxibenzamina
  • Dibenylene
  • Fenossibenzamina
  • Phenoxybenzaminum
  • Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-
  • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine
  • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine
  • 2-(N-Benzyl-2-chloroethylamino)-1-phenoxypropane
  • Benzyl(2-chloroethyl)-(1-methyl-2-phenoxyethyl)amine
  • N-Phenoxyisopropyl-N-benzyl-beta-chloroethylamine
  • benzyl(2-chloroethyl)(1-phenoxypropan-2-yl)amine
  • Benzylamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-
  • (+-)-Phenoxybenzamine
  • N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine
  • Dibenzyline
  • N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine
  • Phenoxybenzamine (INN)
  • Bensylyte
  • 59-96-1 (free)
  • 4-12-00-02204 (Beilstein Handbook Reference)
  • DivK1c_000800

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from petroleum etherexp.
Melting point
137.5 to 140 °Cexp.
Solubility
WHITE CRYSTALLINE POWDER, SOL IN 9 PARTS CHLOROFORM, INSOL IN DIETHYLETHER /PHENOXYBENZAMINE HYDROCHLORIDE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
303.83 g/molcalc.
Exact mass
303.139 Dacalc.
LogP (octanol/water)
4.19calc.
Topological polar surface area
12.47 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
8calc.
Heavy atoms
21calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CNCCOc2ccccc2)cc1

c1ccc(CNCCOc2ccccc2)cc1

2 rings, 17 atoms, the Benzyl-(2-phenoxy-ethyl)-amine ring system.

100 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Phenoxybenzamine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 32 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

32 suppliers in 12 countries

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Phenoxybenzamine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adrenergic alpha-Antagonists
  • Antihypertensive Agents
  • Vasodilator Agents

Roles

  • antineoplastic agent
  • cardiovascular drug
  • pharmaceutical

Pharmacology

Phenoxybenzamine is an alpha-Adrenergic Blocker. The mechanism of action of phenoxybenzamine is as an Adrenergic alpha-Antagonist.

How it is made

Reaction of 2-phenoxy-1-methyl ethanol with thionyl chloride, followed by reaction with ethanolamine, benzyl chloride, & thionyl chloride

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Phenoxybenzamine is traded under.

HS 2922.29Indicative HS code

Amino-naphthols and other amino-phenols, other than those containing more than one kind…

World exports in 2024
$467M
−15.3% vs 2023, imports $454M
2019 to 2024
Top exporters
  1. China63.1%
  2. India * partner reported15.5%
  3. Japan4.0%
Top importers
  1. India * partner reported25.8%
  2. United States14.4%
  3. South Korea7.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Phenoxybenzamine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Phenoxybenzamine, based on the data on this page

What is Phenoxybenzamine?

Phenoxybenzamine is an aromatic amine.

What is the CAS number of Phenoxybenzamine?

The CAS registry number of Phenoxybenzamine is 59-96-1. Other or deprecated CAS numbers: 102737-84-8.

What is the molecular formula and weight of Phenoxybenzamine?

The molecular formula of Phenoxybenzamine is C18H22ClNO and its molar mass is 303.83 g/mol.

What is Phenoxybenzamine used for?

Use classes: Pharmaceuticals.

Is Phenoxybenzamine hazardous?

No GHS hazard classification for Phenoxybenzamine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Phenoxybenzamine?

Phenoxybenzamine is usually classified under HS code 292229 (Amino-naphthols and other amino-phenols, other than those containing more than one kind…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Phenoxybenzamine?

CompoundList lists 32 suppliers of Phenoxybenzamine in United States, China, Germany, Canada and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Phenoxybenzamine in India?

1 supplier in India list Phenoxybenzamine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Phenoxybenzamine?

Suppliers quote Phenoxybenzamine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Phenoxybenzamine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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