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Screening compounds

Phorbol

Also known as 4-beta-Phorbol, 4beta-Phorbol, 4,9,12-beta,13,20-Pentahydroxy-1,6-tigliadien-3-on

CAS 17673-25-5Formula C20H28O6Molar mass 364.44 g/molEC 634-015-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 49 suppliers listed
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Phorbol chemical structure, C20H28O6, CAS 17673-25-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Anhydrous crystals, two forms of solvated crystals from ethyl acetate, solvated crystals…
Melting point
250 to 251
Density
Density of solvated phorbol: 1.2 g/cm³, where solvated phorbol contains one phorbol mole…
Solubility
Quite soluble in polar solvents, including water
HS code
291440
Category
Screening compounds
UN number
UN 2811
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Phorbol?

Plain description, key identifiers and synonyms

Phorbol is a diterpenoid with the structure of tigliane hydroxylated at C-4, -9, -12(beta), -13 and -20, with an oxo group at C-3 and unsaturation at the 1- and 6-positions. It is a tertiary alpha-hydroxy ketone, a tertiary alcohol, a cyclic ketone, an enone and a tetracyclic diterpenoid. It derives from a hydride of a tigliane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,2S,6R,10S,11R,13S,14R,15R)-1,6,13,14-tetrahydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyltetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dien-5-one
CAS number
17673-25-5 CAS number cross-checked
EC number
634-015-4
Molecular formula
C20H28O6
UNII
XUZ76S9127
MDL number
MFCD00065450
InChIKey
QGVLYPPODPLXMB-UBTYZVCOSA-N
InChI
InChI=1S/C20H28O6/c1-9-5-13-18(24,15(9)22)7-11(8-21)6-12-14-17(3,4)20(14,26)16(23)10(2)19(12,13)25/h5-6,10,12-14,16,21,23-26H,7-8H2,1-4H3/t10-,12+,13-,14-,16-,18-,19-,20-/m1/s1
Canonical SMILES
CC1=CC2C(O)(CC(CO)=CC3C4C(C)(C)C4(O)C(O)C(C)C32O)C1=O
Isomeric SMILES
C[C@@H]1[C@H]([C@@]2([C@@H](C2(C)C)[C@H]3[C@]1([C@@H]4C=C(C(=O)[C@]4(CC(=C3)CO)O)C)O)O)O

Synonyms

  • 4-beta-Phorbol
  • 4beta-Phorbol
  • 4,9,12-beta,13,20-Pentahydroxy-1,6-tigliadien-3-on
  • 4,9,12beta,13,20-pentahydroxy-1,6-tigliadien-3-on
  • 4,9,12beta,13,20-pentahydroxytiglia-1,6-dien-3-one
  • (1S,2S,6R,10S,11R,13S,14R,15R)-1,6,13,14-tetrahydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyltetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dien-5-one
  • (1S,2S,6R,10S,11R,13S,14R,15R)-1,6,13,14-tetrahydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyltetracyclo(8.5.0.02,6.011,13)pentadeca-3,8-dien-5-one
  • 4-Phorbol
  • PhorbolPhorbol
  • 4.b.-Phorbol
  • 4|?-Phorbol
  • tetrahydroxy-(hydroxymethyl)-tetramethyl-[?]one
  • (1S,2S,6R,10S,11R,13S,14R,15R)-1,6,13,14-tetrahydroxy-8-(hydroxymethy
  • (1S,2S,6R,10S,11R,13S,14R,15R)-1,6,13,14-tetrahydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dien-5-one
  • (1S,2S,6R,10S,11R,13S,14R,15R)-1,6,13,14-tetrahydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyltetracyclo[8.5.0.0^{2,6}.0^{11,13}]pentadeca-3,8-dien-5-one
  • 4,9,12beta,13,20-pentahydroxy-1,6-tigliadien-3-on, 4,9,12beta,13,20-pentahydroxytiglia-1,6-dien-3-one, Phorbol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Anhydrous crystals, two forms of solvated crystals from ethyl acetate, solvated crystals from methanol or ethanolexp.
Melting point
250 to 251exp.
Density
Density of solvated phorbol: 1.2 g/cm³, where solvated phorbol contains one phorbol molecule and one ethanol molecule.exp.
Solubility
Quite soluble in polar solvents, including waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
364.44 g/molcalc.
Exact mass
364.1886 Dacalc.
LogP (octanol/water)
-0.07calc.
Topological polar surface area
118.2 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
1calc.
Heavy atoms
26calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.75calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C1CC=CC1C3CC3CCC21

O=C1C=CC2C1CC=CC1C3CC3CCC21

4 rings, 16 atoms.

136 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H300Fatal if swallowed.
  • H310Fatal in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H330Fatal if inhaled.
  • H335May cause respiratory irritation.
Precautionary statements (25)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P319Get medical help if you feel unwell.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Phorbol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 49 suppliers
30 of 30 offers
  • 001Chemical
    China, HangzhouUnclaimed profile
    PhorbolGrade, purity and minimum order on request
    Price on request
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  • 10X Chem
    United States, San DiegoUnclaimed profile
    PhorbolGrade, purity and minimum order on request
    Price on request
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  • 3WAY Pharm Inc
    China, ShanghaiUnclaimed profile
    PhorbolGrade, purity and minimum order on request
    Price on request
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  • A2B Chem LLC
    United States, San DiegoUnclaimed profile
    PhorbolGrade, purity and minimum order on request
    Price on request
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  • Aa Blocks LLC
    United States, San DiegoUnclaimed profile
    PhorbolGrade, purity and minimum order on request
    Price on request
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  • Aaron Chemicals LLC.
    China, NanjingUnclaimed profile
    PhorbolGrade, purity and minimum order on request
    Price on request
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  • AbaChemScene, LLC
    United States, Monmouth JunctionUnclaimed profile
    PhorbolGrade, purity and minimum order on request
    Price on request
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  • ABCR GmbH & CO. KG
    GermanyUnclaimed profile
    PhorbolGrade, purity and minimum order on request
    Price on request
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  • AChemBlock
    United States, HaywardUnclaimed profile
    PhorbolGrade, purity and minimum order on request
    Price on request
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  • Achemtek
    United States, WoburnUnclaimed profile
    PhorbolGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

49 suppliers in 11 countries

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Phorbol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Biochemical and medical research.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Phorbol is traded under.

HS 2914.40Indicative HS code

Ketone-alcohols and ketone-aldehydes

World exports in 2024
$199M
+2.5% vs 2023, imports $247M
2019 to 2024
Top exporters
  1. China29.5%
  2. Germany14.4%
  3. Netherlands12.7%
Top importers
  1. United States37.2%
  2. Netherlands8.5%
  3. Germany6.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Phorbol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Phorbol, based on the data on this page

What is Phorbol?

Phorbol is a diterpenoid with the structure of tigliane hydroxylated at C-4, -9, -12(beta), -13 and -20, with an oxo group at C-3 and unsaturation at the 1- and 6-positions. It is a tertiary alpha-hydroxy ketone, a tertiary alcohol, a cyclic ketone, an enone and a tetracyclic diterpenoid.

What is the CAS number of Phorbol?

The CAS registry number of Phorbol is 17673-25-5.

What is the molecular formula and weight of Phorbol?

The molecular formula of Phorbol is C20H28O6 and its molar mass is 364.44 g/mol.

What is Phorbol used for?

Biochemical and medical research.

Is Phorbol hazardous?

Phorbol carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Phorbol?

Phorbol is usually classified under HS code 291440 (Ketone-alcohols and ketone-aldehydes). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Phorbol?

CompoundList lists 49 suppliers of Phorbol in United States, China, Germany, Spain and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Phorbol?

Suppliers quote Phorbol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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