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Other active pharmaceutical ingredients

Pilocarpine

Also known as Pilokarpin, Pilocarpol, Syncarpine

CAS 92-13-7Formula C11H16N2O2Molar mass 208.26 g/molEC 202-128-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 53 suppliers listed Drug substance
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Pilocarpine chemical structure, C11H16N2O2, CAS 92-13-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Oil or crystals
Melting point
34 °C
Boiling point
260 °C
Solubility
SOL IN WATER, ALC, CHLOROFORM, SPARINGLY SOL IN ETHER, BENZENE, ALMOST INSOL IN PETROLEU…
HS code
293979
Category
Other active pharmaceutical ingredients
Illustrative photo, 200 litre blue HDPE drums of liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Pilocarpine?

Plain description, key identifiers and synonyms

(+)-pilocarpine is the (+)-enantiomer of pilocarpine. It has a role as an antiglaucoma drug. It is an enantiomer of a (-)-pilocarpine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
CAS number
92-13-7 CAS number cross-checkedOther or deprecated CAS: 102282-25-7, 54-71-7
EC number
202-128-4
Molecular formula
C11H16N2O2
UNII
01MI4Q9DI3
MDL number
MFCD00153042
InChIKey
QCHFTSOMWOSFHM-WPRPVWTQSA-N
InChI
InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1
Canonical SMILES
CCC1C(=O)OCC1Cc1cncn1C
Isomeric SMILES
CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C

Synonyms

  • Pilokarpin
  • Pilocarpol
  • Syncarpine
  • Ocusert pilo
  • Pilocarpin
  • Spersacarpine
  • Ocusert pilo-20
  • Ocusert Pilo-40
  • Ocusert P 20
  • ocucarpine
  • Pilocarpine muriate
  • Pilovisc
  • Pilocarpinum
  • Spersacarpine hydrochloride
  • Pilokarpin monohydrochloride
  • (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one
  • (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
  • Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone
  • (3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone
  • Hydrochloride, Pilocarpine
  • (3S,4R)-3-ethyl-4-((3-methylimidazol-4-yl)methyl)oxolan-2-one
  • (3S,4R)-3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)oxolan-2-one
  • Nitrate, Pilocarpine
  • Pilocarpine Mononitrate, (3S-cis)-
  • Pilocarpine, Monohydrochloride, (3S-cis)-
Show all 38 synonyms
  • (+)-Pilocarpine
  • Adsorbocarpine
  • Isoptocarpine
  • Epicar
  • Pilocarpine chloride
  • (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
  • (3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one
  • Pilokarpol
  • (3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone
  • (3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone
  • 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)-
  • (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]tetrahydrofuran-2-one
  • 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Oil or crystalsexp.
Melting point
34 °Cexp.
Boiling point
260 °Cexp.
Solubility
SOL IN WATER, ALC, CHLOROFORM, SPARINGLY SOL IN ETHER, BENZENE, ALMOST INSOL IN PETROLEUM ETHERexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
208.26 g/molcalc.
Exact mass
208.1212 Dacalc.
LogP (octanol/water)
1.16calc.
Topological polar surface area
44.12 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
15calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.64calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CC(Cc2cnc[nH]2)CO1

O=C1CC(Cc2cnc[nH]2)CO1

2 rings, 12 atoms.

20 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300Fatal if swallowed.
  • H330Fatal if inhaled.
Precautionary statements (14)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pilocarpine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 53 suppliers
30 of 30 offers
  • Aristopharma Ltd.
    Bangladesh, Dhaka ManufacturerUnclaimed profile
    PilocarpineGrade, purity and minimum order on request
    Price on request
    View
  • 9M India Limited
    India ManufacturerUnclaimed profile
    PilocarpineGrade, purity and minimum order on request
    Price on request
    View
  • Allas Chem Tech
    IndiaUnclaimed profile
    PilocarpineGrade, purity and minimum order on request
    Price on request
    View
  • ophthpharma.com
    Pakistan ManufacturerUnclaimed profile
    PilocarpineGrade, purity and minimum order on request
    Price on request
    View
  • 001Chemical
    China, HangzhouUnclaimed profile
    PilocarpineGrade, purity and minimum order on request
    Price on request
    View
  • 10X Chem
    United States, San DiegoUnclaimed profile
    PilocarpineGrade, purity and minimum order on request
    Price on request
    View
  • 3WAY Pharm Inc
    China, ShanghaiUnclaimed profile
    PilocarpineGrade, purity and minimum order on request
    Price on request
    View
  • A2B Chem LLC
    United States, San DiegoUnclaimed profile
    PilocarpineGrade, purity and minimum order on request
    Price on request
    View
  • Aa Blocks LLC
    United States, San DiegoUnclaimed profile
    PilocarpineGrade, purity and minimum order on request
    Price on request
    View
  • Aaron Chemicals LLC.
    China, NanjingUnclaimed profile
    PilocarpineGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

53 suppliers in 14 countries

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Pilocarpine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Pharmacological actions

  • Miotics
  • Muscarinic Agonists

Roles

  • antiglaucoma drug
  • ophthalmology drug
  • pharmaceutical

Pharmacology

Pilocarpine is a Cholinergic Receptor Agonist. The mechanism of action of pilocarpine is as a Cholinergic Agonist and Cholinergic Muscarinic Agonist.

How it is made

Total alkaloids are extracted from...suitable pilocarpus species, with alc containing small amt of hydrochloric acid. Solvent distd off...resins are all deposited. ...Filtered...evaporated to small bulk. Ammonia is added in excess & free alkaloids extracted with chloroform.

Preobrashenski et al, ber 66, 1187 (1933), samokh alov, med prom sssr 11, no 2, 10 (1957)...

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 614-016-00-6

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Pilocarpine and its salts, Ref no: 283, Annex ref: II/283
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pilocarpine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Pilocarpine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pilocarpine, based on the data on this page

What is Pilocarpine?

(+)-pilocarpine is the (+)-enantiomer of pilocarpine. It has a role as an antiglaucoma drug. It is an enantiomer of a (-)-pilocarpine.

What is the CAS number of Pilocarpine?

The CAS registry number of Pilocarpine is 92-13-7. Other or deprecated CAS numbers: 102282-25-7, 54-71-7.

What is the molecular formula and weight of Pilocarpine?

The molecular formula of Pilocarpine is C11H16N2O2 and its molar mass is 208.26 g/mol.

What is Pilocarpine used for?

Veterinary medication:.

Is Pilocarpine hazardous?

Pilocarpine carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pilocarpine?

Pilocarpine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pilocarpine?

CompoundList lists 53 suppliers of Pilocarpine in United States, China, Germany, Spain and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Pilocarpine in India?

2 suppliers in India list Pilocarpine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Pilocarpine?

Suppliers quote Pilocarpine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pilocarpine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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