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Antibiotics and anti-infectives

Plerixafor

Also known as Mozobil, Amd 3100, SDZ SID 791

CAS 110078-46-1Formula C28H54N8Molar mass 502.80 g/molEC 842-163-8
GHS signal word: Warning. Pictograms: Harmful or irritant 93 suppliers listed Drug substance
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Plerixafor chemical structure, C28H54N8, CAS 110078-46-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
110078-46-1
Formula
C28H54N8
Molar mass
502.80 g/mol
EC number
842-163-8
HS code
293399
Category
Antibiotics and anti-infectives

What is Plerixafor?

Plain description, key identifiers and synonyms

Plerixafor is an azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma. It has a role as a C-X-C chemokine receptor type 4 antagonist, an antineoplastic agent, an immunological adjuvant and an anti-HIV agent. It is a member of benzenes, a crown amine, an azacycloalkane, a secondary amino compound, a tertiary amino compound and an azamacrocycle. It is functionally related to a 1,4,8,11-tetraazacyclotetradecane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
CAS number
110078-46-1 CAS number cross-checkedOther or deprecated CAS: 155148-31-5
EC number
842-163-8
Molecular formula
C28H54N8
UNII
S915P5499N
MDL number
MFCD05662218
InChIKey
YIQPUIGJQJDJOS-UHFFFAOYSA-N
InChI
InChI=1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2
SMILES (canonical and isomeric)
C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3

Synonyms

  • Mozobil
  • Amd 3100
  • SDZ SID 791
  • plerixaforum
  • 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
  • JKL 169
  • 1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane
  • 1,4,8,11-Tetraazacyclotetradecane, 1,1'-(1,4-phenylenebis(methylene))bis-
  • 1,1'-(1,4-Phenylenebis(methylene))bis-1,4,8,11-tetraazacyclotetradecane
  • 1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylmethyl)phenyl]methyl}-1,4,8,11-tetraazacyclotetradecane
  • mezobil
  • RPA bicyclam
  • 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-
  • 1-((4-(1,4,8,11-tetraazacyclotetradecan-1-ylmethyl)phenyl)methyl)-1,4,8,11-tetraazacyclotetradecane
  • 1-((4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl)methyl)-1,4,8,11-tetrazacyclotetradecane
  • 1,1'-(1,4-Phenylenebis(methylene))-bis-1,4,8,11-tetraazacyclotetradecane
  • 1,1'-(1,4-phenylenebis-(methylene))-bis-1,4,8,11-tetraazacyclotetradecane
  • 1,1'-(1,4-phenylenebis(methylene))bis(1,4,8,11-tetraazacyclotetradecane)octahydrochloride dihydrate
  • 1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene
  • bicyclam JM-2987
  • Plerixafor hydrochloride
  • Plerixafor 8HCl
  • GNA & AMD-3100
  • JM 2987
  • 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]
Show all 31 synonyms
  • plerixafor (amd3100)
  • 1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane)
  • Mozobil (TN)
  • HHA & AMD-3100
  • Plerixafor (Standard)
  • AMD3100 (Plerixafor)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
502.80 g/molcalc.
Exact mass
502.4471 Dacalc.
LogP (octanol/water)
0.42calc.
Topological polar surface area
78.66 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
4calc.
Heavy atoms
36calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.79calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(CN2CCCNCCNCCCNCC2)ccc1CN1CCCNCCNCCCNCC1

c1cc(CN2CCCNCCNCCCNCC2)ccc1CN1CCCNCCNCCCNCC1

3 rings, 36 atoms. This chemical is the scaffold itself.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Plerixafor suppliers

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Where suppliers are based

93 suppliers in 15 countries

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Plerixafor price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Anti-HIV Agents

Roles

  • C-X-C chemokine receptor type 4 antagonist
  • adjuvant
  • antagonist
  • anti-HIV agent
  • anti-anaemic agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • hypoglycemic agent
  • immunological adjuvant
  • immunomodulator
  • pharmaceutical
  • protective agent
  • renoprotective agent

Pharmacology

Plerixafor is a Hematopoietic Stem Cell Mobilizer. The physiologic effect of plerixafor is by means of Increased Hematopoietic Stem Cell Mobilization.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Plerixafor is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Plerixafor is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Plerixafor, based on the data on this page

What is Plerixafor?

Plerixafor is an azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer.

What is the CAS number of Plerixafor?

The CAS registry number of Plerixafor is 110078-46-1. Other or deprecated CAS numbers: 155148-31-5.

What is the molecular formula and weight of Plerixafor?

The molecular formula of Plerixafor is C28H54N8 and its molar mass is 502.80 g/mol.

What is Plerixafor used for?

Known uses and roles of Plerixafor include antivirals in pharmaceuticals, c-x-c chemokine receptor type 4 antagonist, adjuvant, antagonist, anti-hiv agent and 11 more.

Is Plerixafor hazardous?

Plerixafor carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Plerixafor?

Plerixafor is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Plerixafor?

CompoundList lists 93 suppliers of Plerixafor in United States, China, India, Germany and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Plerixafor in India?

9 suppliers in India list Plerixafor on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Plerixafor?

Suppliers quote Plerixafor on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Plerixafor

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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