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Cardiovascular and metabolic drugs

Polydatin

Also known as Piceid, Trans-Piceid, 3,4,5-Trihydroxystilbene-3-beta-monoglucoside

CAS 27208-80-6Formula C20H22O8Molar mass 390.39 g/molEC 111-790-2
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant 79 suppliers listed Drug substance
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Polydatin chemical structure, C20H22O8, CAS 27208-80-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
27208-80-6
Formula
C20H22O8
Molar mass
390.39 g/mol
EC number
111-790-2
HS code
293299
Category
Cardiovascular and metabolic drugs

What is Polydatin?

Plain description, key identifiers and synonyms

Trans-piceid is a stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue. It has a role as a geroprotector, an antioxidant, a metabolite, an anti-arrhythmia drug, a potassium channel modulator, a hepatoprotective agent and a nephroprotective agent. It is a beta-D-glucoside, a polyphenol, a stilbenoid and a monosaccharide derivative. It is functionally related to a trans-resveratrol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
CAS number
27208-80-6 CAS number cross-checkedOther or deprecated CAS: 65914-17-2
EC numbers
111-790-2, 683-198-7
Molecular formula
C20H22O8
UNII
XM261C37CQ
MDL number
MFCD00210592
InChIKey
HSTZMXCBWJGKHG-CUYWLFDKSA-N
InChI
InChI=1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16-,17-,18+,19-,20-/m1/s1
Canonical SMILES
OCC1OC(Oc2cc(O)cc(C=Cc3ccc(O)cc3)c2)C(O)C(O)C1O
Isomeric SMILES
C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O

Synonyms

  • Piceid
  • Trans-Piceid
  • 3,4,5-Trihydroxystilbene-3-beta-monoglucoside
  • 3,4,5-Tsg
  • Resveratrol 3-beta-mono-D-glucoside
  • Resveratrol 3-O-beta-glucopyranoside
  • 3,4'-5-Trihydroxystilbene-3-beta-D-glucopyranoside
  • resveratrol 3-O-beta-D-glucoside
  • trans-resveratrol 3-beta-glucoside
  • trans-resveratrol 3-beta-D-glucoside
  • trans-resveratrol 3-O-beta-D-glucoside
  • 3,4',5-trihydroxystilbene-3-beta-D-glucoside
  • 3-Hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-beta-D-glucoside
  • beta-D-Glucopyranoside, 3-hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl
  • beta-D-Glucopyranoside, 3-hydroxy-5-[2-(4-hydroxyphenyl)ethenyl]phenyl
  • Polydatin (E)-
  • polydatin, (E)-
  • Sooryehan Pure-Whitening
  • resveratrol-3-O-glucoside
  • Sooryehan Pure-Whitening Essence
  • Sooryehan Pure Whitening Spot Treatment
  • 5,4'-dihydroxystilbene-3-O-beta-D-Glcp
  • (2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  • Resveratrol 3-O-glucoside
  • (E)-Piceid
Show all 39 synonyms
  • (E/Z)-Piceid
  • (2S,3R,4S,5S,6R)-2-(3-hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-(4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • resveratrol-3-O-b-mono-D-glucoside
  • 3,5,4'-Trihydroxystilbene 3-glucoside
  • (2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)vinyl]phenoxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
  • beta-D-Glucopyranoside, 3-hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-, (E)-
  • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-oxidanyl-phenoxy]oxane-3,4,5-triol
  • (2S,3R,4S,5S,6R)-2-[3-Hydroxy-5-[(E)-4-hydroxystyryl]phenoxy]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • Resveratrol 3-Glucoside
  • trans Resveratrol 3-O-b-D-glucopyranoside, 98%
  • picied
  • b-D-Glucopyranoside, 3-hydroxy-5-[2-(4-hydroxyphenyl)ethenyl]phenyl
  • E/Z-Polydatin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
390.39 g/molcalc.
Exact mass
390.1315 Dacalc.
LogP (octanol/water)
0.45calc.
Topological polar surface area
139.8 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
5calc.
Heavy atoms
28calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C(=Cc1cccc(OC2CCCCO2)c1)c1ccccc1

C(=Cc1cccc(OC2CCCCO2)c1)c1ccccc1

3 rings, 21 atoms.

21 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (18)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Polydatin suppliers

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All 79 suppliers
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Where suppliers are based

79 suppliers in 12 countries

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Polydatin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • anti-arrhythmia drug
  • antioxidant
  • biophysical role
  • cardiovascular drug
  • geroprotector
  • hepatoprotective agent
  • membrane transport modulator
  • metabolite
  • nephroprotective agent
  • pharmaceutical
  • potassium channel modulator
  • protective agent

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Polydatin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Polydatin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Polydatin, based on the data on this page

What is Polydatin?

Trans-piceid is a stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue. It has a role as a geroprotector, an antioxidant, a metabolite, an anti-arrhythmia drug, a potassium channel modulator, a hepatoprotective agent and a nephroprotective agent.

What is the CAS number of Polydatin?

The CAS registry number of Polydatin is 27208-80-6. Other or deprecated CAS numbers: 65914-17-2.

What is the molecular formula and weight of Polydatin?

The molecular formula of Polydatin is C20H22O8 and its molar mass is 390.39 g/mol.

What is Polydatin used for?

Known uses and roles of Polydatin include cardiovascular drugs in pharmaceuticals, anti-arrhythmia drug, antioxidant, biophysical role, cardiovascular drug and 8 more.

Is Polydatin hazardous?

Polydatin carries the GHS signal word "Danger". Main hazards: causes skin irritation, causes serious eye damage, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Polydatin?

Polydatin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Polydatin?

CompoundList lists 79 suppliers of Polydatin in United States, China, Germany, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Polydatin?

Suppliers quote Polydatin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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