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Respiratory, allergy and digestive drugs

Proglumide

Also known as 4-benzamido-5-(dipropylamino)-5-oxopentanoic acid, Binoside, Xylamide

CAS 6620-60-6Formula C18H26N2O4Molar mass 334.42 g/molEC 229-567-4
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Proglumide chemical structure, C18H26N2O4, CAS 6620-60-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
6620-60-6
Formula
C18H26N2O4
Molar mass
334.42 g/mol
EC number
229-567-4
HS code
292429
Category
Respiratory, allergy and digestive drugs

What is Proglumide?

Plain description, key identifiers and synonyms

Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as an opioid analgesic, a cholinergic antagonist, a drug metabolite, an anti-ulcer drug, a gastrointestinal drug, a delta-opioid receptor agonist, a cholecystokinin antagonist and a xenobiotic metabolite. It contains a (R)-proglumide and a (S)-proglumide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-benzamido-5-(dipropylamino)-5-oxopentanoic acid
CAS number
6620-60-6 CAS number cross-checkedOther or deprecated CAS: 24485-90-3
EC number
229-567-4
Molecular formula
C18H26N2O4
UNII
EPL8W5565D
MDL number
MFCD00055071
InChIKey
DGMKFQYCZXERLX-UHFFFAOYSA-N
InChI
InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
SMILES (canonical and isomeric)
CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC=CC=C1

Synonyms

  • 4-benzamido-5-(dipropylamino)-5-oxopentanoic acid
  • Binoside
  • Xylamide
  • dl-proglumide
  • Milid
  • Nulsa
  • Gastrotopic
  • Midelid
  • Ulcutin
  • Proglumida
  • Xyde
  • Proglumidum
  • Promid
  • 242 DL
  • (+-)-4-Benzamido-N,N-dipropylglutaramic acid
  • Glutaramic acid, 4-benzamido-N,N-dipropyl-, DL-
  • 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid
  • Xilamide
  • (4RS)-4-Benzoylamino-N,N-dipropylglutaramic acid
  • Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-
  • Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (+-)-
  • Milide
  • 4-Benzoylamino-5-dipropylamino-5-oxopentanoic acid sodium salt
  • Promide (parasympatholytic)
  • CR 242
Show all 33 synonyms
  • Xylamide (gastroprotective agent)
  • 4-(N,N-dipropylcarbamoyl)-4-(phenylcarbonylamino)butanoic acid
  • DL-4-benzamido-N,N-dipropylglutaramic acid
  • racemic proglumide
  • (RS)-proglumide
  • (+-)-proglumide
  • Nulsa (TN)
  • (+/-)-Proglumide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
334.42 g/molcalc.
Exact mass
334.1893 Dacalc.
LogP (octanol/water)
2.3calc.
Topological polar surface area
86.71 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
10calc.
Heavy atoms
24calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Proglumide suppliers

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All 45 suppliers
30 of 30 offers

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Where suppliers are based

45 suppliers in 11 countries

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Proglumide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Ulcer Agents

Roles

  • agonist
  • analgesic
  • antagonist
  • anti-ulcer drug
  • antineoplastic agent
  • cholecystokinin antagonist
  • cholinergic antagonist
  • cholinergic drug
  • delta-opioid agent
  • delta-opioid receptor agonist
  • drug metabolite
  • gastrointestinal drug
  • hepatoprotective agent
  • hormone antagonist
  • hormone receptor modulator
  • metabolite
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical
  • protective agent
  • receptor modulator
  • xenobiotic metabolite

Pharmacology

Proglumide is an orally bioavailable cholecystokinin (CCK) receptor antagonist, with gastric acid reducing and potential antineoplastic activities. Upon oral administration, proglumide binds to and blocks both cholecystokinin receptor type A (CCK-AR, CCK1-R) and gastrin/cholecystokinin type B receptor (CCK-BR, CCK2-R). This prevents the binding of cholecystokinin and gastrin to the CCK receptors, and inhibits both gastrointestinal (GI) motility and gastric secretions. This may also decrease fibrosis in the tumor microenvironment (TME), increase both the infiltration of T-cells and the penetration of chemotherapeutic agents, and inhibit tumor growth and metastasis. CCK receptors, normally expressed in the GI tract and the nervous system, are overexpressed on fibroblasts and certain cancers.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Proglumide is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Proglumide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Proglumide, based on the data on this page

What is Proglumide?

Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.

What is the CAS number of Proglumide?

The CAS registry number of Proglumide is 6620-60-6. Other or deprecated CAS numbers: 24485-90-3.

What is the molecular formula and weight of Proglumide?

The molecular formula of Proglumide is C18H26N2O4 and its molar mass is 334.42 g/mol.

What is Proglumide used for?

Use classes: Pharmaceuticals.

Is Proglumide hazardous?

No GHS hazard classification for Proglumide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Proglumide?

Proglumide is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Proglumide?

CompoundList lists 45 suppliers of Proglumide in United States, China, United Kingdom, Canada and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Proglumide?

Suppliers quote Proglumide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Proglumide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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