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Cardiovascular and metabolic drugs

Propafenone

Also known as Propafenona, Propafenonum, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one

CAS 54063-53-5Formula C21H27NO3Molar mass 341.45 g/molEC 258-955-6
GHS signal word: Warning. Pictograms: Harmful or irritant 66 suppliers listed Drug substance
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Propafenone chemical structure, C21H27NO3, CAS 54063-53-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
54063-53-5
Formula
C21H27NO3
Molar mass
341.45 g/mol
EC number
258-955-6
HS code
292250
Category
Cardiovascular and metabolic drugs

What is Propafenone?

Plain description, key identifiers and synonyms

Propafenone is an aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It is a secondary alcohol, a secondary amino compound and an aromatic ketone. It is a conjugate base of a propafenone(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
CAS number
54063-53-5 CAS number cross-checkedOther or deprecated CAS: 9083-41-4
EC number
258-955-6
Molecular formula
C21H27NO3
UNII
68IQX3T69U
MDL number
MFCD00216020
INCI name
PROPAFENONE
InChIKey
JWHAUXFOSRPERK-UHFFFAOYSA-N
InChI
InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
SMILES (canonical and isomeric)
CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O

Synonyms

  • Propafenona
  • Propafenonum
  • 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one
  • Propafenon Hexal
  • GNF-Pf-4594
  • 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone
  • 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
  • 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one
  • 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-
  • 2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone
  • 1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-
  • Norfenon
  • Pintoform
  • Propafenon Minden
  • Rythmol
  • Propafenone (INN)
  • 1-[2-(2-hydroxy-3-propylamino-propoxy)phenyl]-3-phenyl-propan-1-one
  • Paraffin with ceresin
  • 1-(2-(2-Hydroxy-3-propylaminopropoxy)phenyl)-3-phenylpropan-1-one
  • 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-propan-1-one
  • Rhytmol
  • 1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-3-phenylpropan-1-one
  • (R)-SA-79
  • (S)-SA-79
  • (+/-)-Propafenone
Show all 27 synonyms
  • Propafenone (Standard)
  • DivK1c_000906

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
341.45 g/molcalc.
Exact mass
341.1991 Dacalc.
LogP (octanol/water)
3.24calc.
Topological polar surface area
58.56 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
11calc.
Heavy atoms
25calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.38calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCc1ccccc1)c1ccccc1

O=C(CCc1ccccc1)c1ccccc1

2 rings, 16 atoms, the Dihydrochalcone ring system.

1,867 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Propafenone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 66 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

66 suppliers in 13 countries

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Propafenone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Cosmetic ingredient, INCI name PROPAFENONE(skin protecting)

Pharmacological actions

  • Anti-Arrhythmia Agents
  • Voltage-Gated Sodium Channel Blockers

Roles

  • anti-arrhythmia drug
  • cardiovascular drug
  • pharmaceutical

Cosmetic functions

  • Skin protecting

Pharmacology

Propafenone is an Antiarrhythmic.

How it is made

It is synthesized by reaction of epichlorohydrin with 1-(2-hydroxyphenyl)-3-phenyl-1-propanone (made by Friedel-Crafts reaction of 3-phenylpropionyl chloride and phenol) and epoxide ring opening with propylamine.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Propafenone is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Propafenone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Propafenone, based on the data on this page

What is Propafenone?

Propafenone is an aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group.

What is the CAS number of Propafenone?

The CAS registry number of Propafenone is 54063-53-5. Other or deprecated CAS numbers: 9083-41-4.

What is the molecular formula and weight of Propafenone?

The molecular formula of Propafenone is C21H27NO3 and its molar mass is 341.45 g/mol.

What is Propafenone used for?

Use classes: Pharmaceuticals.

Is Propafenone hazardous?

Propafenone carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Propafenone?

Propafenone is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Propafenone?

CompoundList lists 66 suppliers of Propafenone in United States, China, India, Germany and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Propafenone in India?

5 suppliers in India list Propafenone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Propafenone?

Suppliers quote Propafenone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Propafenone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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