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Analgesics and anti-inflammatories

Salsalate

Also known as sasapyrine, Salicylsalicylic acid, Disalcid

CAS 552-94-3Formula C14H10O5Molar mass 258.23 g/molEC 209-027-4
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 68 suppliers listed Drug substance
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Salsalate chemical structure, C14H10O5, CAS 552-94-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
552-94-3
Formula
C14H10O5
Molar mass
258.23 g/mol
EC number
209-027-4
HS code
291829
Category
Analgesics and anti-inflammatories

What is Salsalate?

Plain description, key identifiers and synonyms

Salsalate is a dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a hypoglycemic agent, an antineoplastic agent, an EC 3.5.2.6 (beta-lactamase) inhibitor, an antirheumatic drug and a prodrug. It is a member of benzoic acids, a member of salicylates, a member of phenols and a benzoate ester. It is functionally related to a salicylic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(2-hydroxybenzoyl)oxybenzoic acid
CAS number
552-94-3 CAS number cross-checked
EC number
209-027-4
Molecular formula
C14H10O5
UNII
V9MO595C9I
MDL number
MFCD00020252
InChIKey
WVYADZUPLLSGPU-UHFFFAOYSA-N
InChI
InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
SMILES (canonical and isomeric)
C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O

Synonyms

  • sasapyrine
  • Salicylsalicylic acid
  • Disalcid
  • 2-Carboxyphenyl salicylate
  • Disalicylic acid
  • Sasapyrinum
  • Sasapyrin
  • 2-(2-hydroxybenzoyl)oxybenzoic acid
  • 2-((2-Hydroxybenzoyl)oxy)benzoic acid
  • Disalicylsaeure
  • Salsalato
  • Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester
  • Salicylic acid, bimolecular ester
  • Salsalatum
  • O-Salicylcylsalicylsaeure
  • Salflex
  • Salicyloxysalicylic acid
  • Disalicyclic acid
  • Mono-gesic
  • 2-[(2-Hydroxybenzoyl)oxy]benzoic acid
  • Salicylic acid bimolecular ester
  • 4-10-00-00165 (Beilstein Handbook Reference)
  • 2-((2-hydroxyphenyl)carbonyloxy)benzoic acid
  • 2-[(2-hydroxyphenyl)carbonyloxy]benzoic acid
  • Salsitab
Show all 38 synonyms
  • Salsalate Rx
  • Diplosal
  • Salicyloylsalicylic acid
  • Saloxium
  • Salysal
  • Diacesal
  • Sasapirin
  • Disalyl
  • Nobacid
  • Salical
  • Salina
  • o-Salicylsalicylic acid
  • Sal Ester Sal

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
258.23 g/molcalc.
Exact mass
258.0528 Dacalc.
LogP (octanol/water)
2.31calc.
Topological polar surface area
83.83 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Oc1ccccc1)c1ccccc1

O=C(Oc1ccccc1)c1ccccc1

2 rings, 15 atoms, the Phenyl benzoate ring system.

2,426 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H400Very toxic to aquatic life.
Precautionary statements (21)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Salsalate suppliers

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All 68 suppliers
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Where suppliers are based

68 suppliers in 14 countries

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Salsalate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Inflammatory Agents, Non-Steroidal

Roles

  • PPAR modulator
  • agonist
  • analgesic
  • anti-anaemic agent
  • anti-inflammatory agent
  • anti-inflammatory drug
  • anti-obesity agent
  • antiatherosclerotic agent
  • antineoplastic agent
  • antirheumatic drug
  • cardiovascular drug
  • enzyme inhibitor
  • hypoglycemic agent
  • insulin-sensitizing drug
  • non-narcotic analgesic
  • non-steroidal anti-inflammatory drug
  • pharmaceutical
  • pro-agent
  • prodrug

Pharmacology

Salsalate is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities. As a prodrug, salsalate is hydrolyzed to salicylic acid which inhibits the expression of cyclooxygenase (COX) enzymes. This prevents the conversion of arachidonic acid into prostaglandin precursors and leads to decreased formation of prostaglandins that are involved in pain, fever and inflammation. In addition, salsalate appears to inhibit nuclear factor-kappa B (NF-kB), thereby preventing activation of the NF-kB-mediated pathway and the expression of genes involved in inflammation.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Salsalate is traded under.

HS 2918.29Indicative HS code

Carboxylic acids, (with phenol function but without other oxygen function), their anhydrides, halides…

World exports in 2024
$861M
+0.9% vs 2023, imports $892M
2019 to 2024
Top exporters
  1. China30.5%
  2. South Korea18.3%
  3. Switzerland * partner reported13.3%
Top importers
  1. United States14.7%
  2. Germany13.3%
  3. Japan10.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Salsalate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Salsalate, based on the data on this page

What is Salsalate?

Salsalate is a dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.

What is the CAS number of Salsalate?

The CAS registry number of Salsalate is 552-94-3.

What is the molecular formula and weight of Salsalate?

The molecular formula of Salsalate is C14H10O5 and its molar mass is 258.23 g/mol.

What is Salsalate used for?

Known uses and roles of Salsalate include analgesics and antipyretics in pharmaceuticals, anti-inflammatories in pharmaceuticals, antidiabetics in pharmaceuticals, ppar modulator, agonist and 18 more.

Is Salsalate hazardous?

Salsalate carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Salsalate?

Salsalate is usually classified under HS code 291829 (Carboxylic acids with phenol function but without other oxygen function, their…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Salsalate?

CompoundList lists 68 suppliers of Salsalate in China, United States, India, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Salsalate in India?

7 suppliers in India list Salsalate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Salsalate?

Suppliers quote Salsalate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Salsalate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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