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Cardiovascular and metabolic drugs

Scoparone

Also known as 6,7-Dimethoxycoumarin, 6,7-Dimethylesculetin, Escoparone

CAS 120-08-1Formula C11H10O4Molar mass 206.20 g/molEC 204-369-0
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 29 suppliers listed
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Scoparone chemical structure, C11H10O4, CAS 120-08-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
120-08-1
Formula
C11H10O4
Molar mass
206.20 g/mol
EC number
204-369-0
HS code
293220
Category
Cardiovascular and metabolic drugs

What is Scoparone?

Plain description, key identifiers and synonyms

Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as an antihypertensive agent, an antilipemic drug, an immunosuppressive agent, an anti-allergic agent, an anti-inflammatory agent and a plant metabolite. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6,7-dimethoxychromen-2-one
CAS number
120-08-1 CAS number cross-checked
EC number
204-369-0
Molecular formula
C11H10O4
UNII
H5841PDT4Y
MDL number
MFCD00006871
INCI name
SCOPARONE
InChIKey
GUAFOGOEJLSQBT-UHFFFAOYSA-N
InChI
InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3
SMILES (canonical and isomeric)
COC1=C(C=C2C(=C1)C=CC(=O)O2)OC

Synonyms

  • 6,7-Dimethoxycoumarin
  • 6,7-Dimethylesculetin
  • Escoparone
  • Scoparon
  • 6,7-Dimethoxy-2H-chromen-2-one
  • Esculetin dimethyl ether
  • Aesculetin dimethyl ether
  • 6,7-dimethoxychromen-2-one
  • Scopoletin methyl ether
  • o-Methylscopoletin
  • 6,7-Dimethoxy-2H-1-benzopyran-2-one
  • o-Methylisoscopoletin
  • o,o-Dimethylesculetin
  • 6,7-Dimethoxy-Coumarin
  • 6,7-Dimethoxybenzopyran-2-one
  • Esculetin 6,7-dimethyl ether
  • 6,7-Dimethoxy-2-benzopyrone
  • 2H-1-Benzopyran-2-one, 6,7-dimethoxy-
  • Dimethyl esculetin
  • Coumarin, 6,7-dimethoxy-
  • Benzopyran-2-one, 6,7-dimethoxy-
  • 6,7-Dimethoxycoumarine
  • Escoparone,
  • o-Methylsco
  • Scoparin?
Show all 34 synonyms
  • Dimethylaesculetin
  • Scoparone (Standard)
  • Di-O-methyl-daphnetin
  • 6,7-dimethoxy coumarin
  • 5-18-03-00204 (Beilstein Handbook Reference)
  • 6,7-Dimethoxy-chromen-2-one
  • 6,7-Dimethoxycoumarin, 98%
  • 6,7-Dimethylesculetin (NIST)
  • ACon1_002079

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
206.20 g/molcalc.
Exact mass
206.0579 Dacalc.
LogP (octanol/water)
1.81calc.
Topological polar surface area
48.67 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
15calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.18calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ccc2ccccc2o1

O=c1ccc2ccccc2o1

2 rings, 11 atoms, the Coumarin ring system.

3,845 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H319Causes serious eye irritation.
Precautionary statements (11)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Scoparone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 29 suppliers
29 of 29 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

29 suppliers in 6 countries

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Scoparone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name SCOPARONE(antioxidant)

Pharmacological actions

  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Cholagogues and Choleretics
  • Vasodilator Agents

Roles

  • anti-allergic agent
  • anti-inflammatory agent
  • antihypertensive agent
  • antilipemic drug
  • cardiovascular drug
  • eukaryotic metabolite
  • immunomodulator
  • immunosuppressive agent
  • metabolite
  • pharmaceutical
  • plant metabolite

Functional uses

  • Antioxidant

Cosmetic functions

  • Antioxidant

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Scoparone is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Scoparone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Scoparone, based on the data on this page

What is Scoparone?

Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups.

What is the CAS number of Scoparone?

The CAS registry number of Scoparone is 120-08-1.

What is the molecular formula and weight of Scoparone?

The molecular formula of Scoparone is C11H10O4 and its molar mass is 206.20 g/mol.

What is Scoparone used for?

Known uses and roles of Scoparone include antihypertensives in pharmaceuticals, cardiovascular drugs in pharmaceuticals, antioxidants in cosmetics and personal care, anti-allergic agent, anti-inflammatory agent and 14 more.

Is Scoparone hazardous?

Scoparone carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Scoparone?

Scoparone is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Scoparone?

CompoundList lists 29 suppliers of Scoparone in China, United States, Germany, United Kingdom and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Scoparone?

Suppliers quote Scoparone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Scoparone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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