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Oncology and immunology drugs

Sirolimus

Also known as rapamycin, (-)-Rapamycin, Rapamune

CAS 53123-88-9Formula C51H79NO13Molar mass 914.19 g/molEC 610-965-5
GHS signal word: Danger. Pictograms: Serious health hazard 108 suppliers listed Drug substance
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Sirolimus chemical structure, C51H79NO13, CAS 53123-88-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless crystalline solid from ether
Melting point
183 to 185
Solubility
In water = 9.9 × 10⁻⁵ mg/L at 25 °C /Estimated/
HS code
293499
Category
Oncology and immunology drugs
Illustrative photo, colourless crystals in a clear glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Sirolimus?

Plain description, key identifiers and synonyms

Sirolimus is a macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent. It has a role as an anticoronaviral agent, a geroprotector, an antineoplastic agent, an immunosuppressive agent, an antibacterial drug, a mTOR inhibitor and a bacterial metabolite. It is a macrolide lactam, an ether, an organic heterotricyclic compound, a secondary alcohol, a cyclic ketone, a cyclic acetal and an antibiotic antifungal drug.

Sirolimus is an immunosuppressive medicine used to prevent rejection of transplanted organs.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
CAS number
53123-88-9 CAS number cross-checked
EC number
610-965-5
Molecular formula
C51H79NO13
UNII
W36ZG6FT64
MDL number
MFCD00867594
InChIKey
QFJCIRLUMZQUOT-HPLJOQBZSA-N
InChI
InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
Canonical SMILES
COC1CC2CCC(C)C(O)(O2)C(=O)C(=O)N2CCCCC2C(=O)OC(C(C)CC2CCC(O)C(OC)C2)CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C1C
Isomeric SMILES
C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC

Synonyms

  • rapamycin
  • (-)-Rapamycin
  • Rapamune
  • rapalimus
  • Fyarro
  • Hyftor
  • sirolimusum
  • Npc-12g
  • Antibiotic AY 22989
  • RAPA
  • Rapammune
  • SILA 9268A
  • sm-88 Component sirolimus
  • AY 22989
  • Wy 090217
  • I 2190A
  • AY 22 989
  • SIIA 9268A
  • Rapamycin (Sirolimus)
  • Rapamycin (GMP)
  • Rapamycin (GMP Like)
  • Rapamycin (>85%)
  • Supralimus
  • Rapamycin/Sirolimus
  • Perceiva
Show all 35 synonyms
  • Cypher
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution
  • 1fkb
  • 1pbk
  • LCP-Siro
  • RAP
  • Scomara
  • Rapamycin (Standard)
  • Rapamycin (Sirolimus)?
  • Human Blood - Sirolimus

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless crystalline solid from etherexp.
Melting point
183 to 185exp.
Solubility
In water = 9.9 × 10⁻⁵ mg/L at 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
914.19 g/molcalc.
Exact mass
913.5551 Dacalc.
LogP (octanol/water)
6.18calc.
Topological polar surface area
195.4 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
13calc.
Rotatable bonds
6calc.
Heavy atoms
65calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.75calc.
Formal charge
0calc.
Stereocentres
15calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC=CCC(=O)CC(CCC2CCCCC2)OC(=O)C2CCCCN2C(=O)C(=O)C2CCCC(CCC=CC=CC=CCCC1)O2

O=C1CCC=CCC(=O)CC(CCC2CCCCC2)OC(=O)C2CCCCN2C(=O)C(=O)C2CCCC(CCC=CC=CC=CCCC1)O2

4 rings, 49 atoms.

78 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H341Suspected of causing genetic defects.
  • H351Suspected of causing cancer.
  • H361Suspected of damaging fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Sirolimus suppliers

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All 108 suppliers
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Where suppliers are based

108 suppliers in 16 countries

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Sirolimus price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Tool for immunochemistry.

Medication: Immunosuppressant.

Use classes: Animal Drugs.

Pharmacological actions

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Antifungal Agents
  • Immunosuppressive Agents

Roles

  • antibacterial agent
  • antibacterial drug
  • anticoronaviral agent
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antineoplastic agent
  • antiviral agent
  • bacterial metabolite
  • enzyme inhibitor
  • geroprotector
  • immunomodulator
  • immunosuppressive agent
  • mTOR inhibitor
  • metabolite
  • pharmaceutical
  • prokaryotic metabolite
  • protective agent
  • protein kinase inhibitor

Pharmacology

Sirolimus is a mTOR Inhibitor Immunosuppressant and Kinase Inhibitor. The mechanism of action of sirolimus is as a mTOR Inhibitor and Protein Kinase Inhibitor. The physiologic effect of sirolimus is by means of Decreased Immunologic Activity.

How it is made

Triene macrolide antibiotic isolated from Streptomyces hygroscopicus.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sirolimus is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Sirolimus is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sirolimus, based on the data on this page

What is Sirolimus?

Sirolimus is a macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.

What is the CAS number of Sirolimus?

The CAS registry number of Sirolimus is 53123-88-9.

What is the molecular formula and weight of Sirolimus?

The molecular formula of Sirolimus is C51H79NO13 and its molar mass is 914.19 g/mol.

What is Sirolimus used for?

Tool for immunochemistry. Medication: Immunosuppressant. Use classes: Animal Drugs.

Is Sirolimus hazardous?

Sirolimus carries the GHS signal word "Danger". Main hazards: suspected of causing genetic defects, suspected of causing cancer, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Sirolimus?

Sirolimus is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Sirolimus?

CompoundList lists 108 suppliers of Sirolimus in China, United States, Germany, India and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Sirolimus in India?

6 suppliers in India list Sirolimus on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Sirolimus?

Suppliers quote Sirolimus on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Sirolimus

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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