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Heterocyclic compounds

Thiolutin

Also known as Acetopyrrothin, Acetopyrrothine, N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide

CAS 87-11-6Formula C8H8N2O2S2Molar mass 228.30 g/molEC 635-840-2
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 4 suppliers listed
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Thiolutin chemical structure, C8H8N2O2S2, CAS 87-11-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
87-11-6
Formula
C8H8N2O2S2
Molar mass
228.30 g/mol
EC number
635-840-2
HS code
293499
Category
Heterocyclic compounds

What is Thiolutin?

Plain description, key identifiers and synonyms

Thiolutin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and acetamido groups, respectively. It is a potent inhibitor of RNA polymerases, inhibits the angiogenesis of human umbilical vein endothelial cells, and also inhibits JAMM metalloproteases. It has a role as a toxin, an antibacterial agent, an antineoplastic agent, an antifungal agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, a chelator, a protein synthesis inhibitor, an angiogenesis inhibitor, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides. It is functionally related to a holomycin.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide
CAS number
87-11-6 CAS number cross-checked
EC number
635-840-2
Molecular formula
C8H8N2O2S2
UNII
02C005Q20B
InChIKey
MHMRAFONCSQAIA-UHFFFAOYSA-N
InChI
InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)
SMILES (canonical and isomeric)
CC(=O)NC1=C2C(=CSS2)N(C1=O)C

Synonyms

  • Acetopyrrothin
  • Acetopyrrothine
  • N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • 3-Acetamido-5-methylpyrrolin-4-one(4,3-d)-1,2-dithiole
  • N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6-yl)acetamide
  • N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide
  • 6-Acetamido-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one
  • N-{4-methyl-5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6-yl}acetamide
  • N-(4-methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • 6-Acetamido-4-methyl-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one
  • N-(4-Methyl-5-oxodithiolo(4,3-b)pyrrol-6-yl)acetamide
  • N-(4-methyl-5-oxo-4,5-dihydro(1,2)dithiolo(4,3-b)pyrrol-6-yl)acetamide
  • N-(4-methyl-5-oxo-4H,5H-(1,2)dithiolo(4,3-b)pyrrol-6-yl)acetamide
  • N-(4-methyl-5-oxo-dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • Farcinicin
  • Farcinicine
  • N-Acetylpyrrothine
  • 6-(Acetylamino)-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one
  • 1,2-DITHIOLO(4.3-b)PYRROL-5(4H)-ONE, 6-ACETAMIDO-4-METHYL-
  • 1, 6-acetamido-4-methyl-
  • N-(4-methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • 6-Acetamido-4-methyl-1,3-b]pyrrol-5[4H]-one
  • N-(4,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • 3-Acetamido-5-methylpyrrolin-4-one[4,2-dithiole
  • 6-(Acetylamino)-4-methyl-1,3-b]pyrrol-5[4H]-one
Show all 30 synonyms
  • 1,2-Dithiolo(4,3-b)pyrrol-5(4H)-one, 6-acetamido-4-methyl-
  • 6-(Acetamido)-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one
  • Acetamide,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-
  • Acetamide, N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6-yl)-
  • N-(4-methyl-3-oxo-7,8-dithia-4-azabicyclo[3.3.0]octa-1,5-dien-2-yl)acetamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
228.30 g/molcalc.
Exact mass
228.0027 Dacalc.
LogP (octanol/water)
1.57calc.
Topological polar surface area
51.1 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
14calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc2sscc-2[nH]1

O=c1cc2sscc-2[nH]1

2 rings, 9 atoms.

14 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300Fatal if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Thiolutin suppliers

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Where suppliers are based

4 suppliers in 3 countries

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Thiolutin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • angiogenesis inhibitor
  • antibacterial agent
  • antifungal agent
  • antimicrobial agent
  • antineoplastic agent
  • bacterial metabolite
  • chelator
  • enzyme inhibitor
  • ligand
  • marine metabolite
  • metabolite
  • pathway inhibitor
  • pharmaceutical
  • poison
  • prokaryotic metabolite
  • protein synthesis inhibitor
  • toxin

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Thiolutin is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Thiolutin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Thiolutin, based on the data on this page

What is Thiolutin?

Thiolutin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and acetamido groups, respectively.

What is the CAS number of Thiolutin?

The CAS registry number of Thiolutin is 87-11-6.

What is the molecular formula and weight of Thiolutin?

The molecular formula of Thiolutin is C8H8N2O2S2 and its molar mass is 228.30 g/mol.

What is Thiolutin used for?

Known uses and roles of Thiolutin include angiogenesis inhibitor, antibacterial agent, antifungal agent, antimicrobial agent, antineoplastic agent and 12 more.

Is Thiolutin hazardous?

Thiolutin carries the GHS signal word "Danger". Main hazards: fatal if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Thiolutin?

Thiolutin is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Thiolutin?

CompoundList lists 4 suppliers of Thiolutin in United States, Australia and Israel. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Thiolutin?

Suppliers quote Thiolutin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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