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Amino acids and derivatives

Timonacic

Also known as Thiazolidine-4-carboxylic acid, 4-Thiazolidinecarboxylic acid, 1,3-Thiazolidine-4-carboxylic acid

CAS 444-27-9Formula C4H7NO2SMolar mass 133.17 g/molEC 207-146-6
GHS signal word: Warning. Pictograms: Harmful or irritant 29 suppliers listed
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Timonacic chemical structure, C4H7NO2S, CAS 444-27-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
444-27-9
Formula
C4H7NO2S
Molar mass
133.17 g/mol
EC number
207-146-6
HS code
293410
Category
Amino acids and derivatives

What is Timonacic?

Plain description, key identifiers and synonyms

Thioproline is a sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom. It has a role as an antioxidant, an antidote and a hepatoprotective agent. It is a sulfur-containing amino acid, a thiazolidinemonocarboxylic acid and a non-proteinogenic alpha-amino acid. It is a tautomer of a thioproline zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,3-thiazolidine-4-carboxylic acid
CAS number
444-27-9 CAS number cross-checked
EC numbers
207-146-6, 242-945-3
Molecular formula
C4H7NO2S
UNII
E5913T3IBL
MDL number
MFCD00128958
INCI name
TIMONACIC
InChIKey
DZLNHFMRPBPULJ-UHFFFAOYSA-N
InChI
InChI=1S/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)
SMILES (canonical and isomeric)
C1C(NCS1)C(=O)O

Synonyms

  • Thiazolidine-4-carboxylic acid
  • 4-Thiazolidinecarboxylic acid
  • 1,3-Thiazolidine-4-carboxylic acid
  • Detoxepa
  • Hepalidine
  • Thioproline
  • Thiaproline
  • Tiazolidin
  • Norgamem
  • DL-Thiaproline
  • 4-Carboxythiazolidine
  • Norgamen
  • Timonacico
  • Heparegen
  • Timonacicum
  • Hepacom
  • DL-Thiazolidinecarboxylic acid
  • Acide thiazolidine-4-carboxylique
  • Acide DL thiazolidine carboxylique-4
  • gamma-thiaproline
  • 4-thiazolidine carboxylic acid
  • 1,3-thiazolidin-3-ium-4-carboxylate
  • Thiazolidine Carboxylic Acid
  • Heparegene
  • USAF C-1
Show all 34 synonyms
  • USAF A-3701
  • Heptaladine
  • Hepaldine
  • Thiazolidinecarboxylic acid
  • Thiazolidine-4-carboxylicacid
  • Timonacic (INN)
  • thiazolidine, 4-carboxy-
  • Thiazolidinecarboxylic acid (VAN)
  • thiazolidin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
133.17 g/molcalc.
Exact mass
133.0197 Dacalc.
LogP (octanol/water)
-0.27calc.
Topological polar surface area
49.33 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
8calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.75calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CSCN1

C1CSCN1

1 ring, 5 atoms, the Thiazolidine ring system.

721 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Timonacic suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 29 suppliers
29 of 29 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

29 suppliers in 11 countries

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Timonacic price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name TIMONACIC(skin conditioning)

Pharmacological actions

  • Anti-Arrhythmia Agents
  • Antidotes
  • Antineoplastic Agents
  • Antioxidants

Roles

  • antidote
  • antioxidant
  • hepatoprotective agent
  • pharmaceutical
  • protective agent

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Timonacic is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities. Acting on cellular membranes of malignant cells through an unknown mechanism, timonacic may induce malignant cells to revert back to an untransformed state. This agent may also restore contact inhibition, a phenomenon characterized by the paracrine inhibition of mitosis following the formation of a critical cell mass, presumably the result of cell-to-cell signal transfer. Timonacic may also produce antioxidant effects secondary to its release of cysteine and restoration of glutathione concentrations.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Timonacic is traded under.

HS 2934.10Indicative HS code

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.88B
−16.1% vs 2023, imports $3.12B
2019 to 2024
Top exporters
  1. Switzerland * partner reported36.4%
  2. Ireland28.8%
  3. China10.0%
Top importers
  1. Canada33.4%
  2. United States14.4%
  3. Ireland13.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Timonacic is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Timonacic, based on the data on this page

What is Timonacic?

Thioproline is a sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom. It has a role as an antioxidant, an antidote and a hepatoprotective agent.

What is the CAS number of Timonacic?

The CAS registry number of Timonacic is 444-27-9.

What is the molecular formula and weight of Timonacic?

The molecular formula of Timonacic is C4H7NO2S and its molar mass is 133.17 g/mol.

What is Timonacic used for?

Known uses and roles of Timonacic include antioxidants in cosmetics and personal care, skin conditioning agents in cosmetics and personal care, antidote, antioxidant, hepatoprotective agent and 8 more.

Is Timonacic hazardous?

Timonacic carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Timonacic?

Timonacic is usually classified under HS code 293410 (Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Timonacic?

CompoundList lists 29 suppliers of Timonacic in China, United States, Hong Kong, Canada and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Timonacic in India?

1 supplier in India list Timonacic on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Timonacic?

Suppliers quote Timonacic on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Timonacic

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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