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Toluene chemical structure, C7H8, CAS 108-88-3
2D chemical structure

Key facts

What buyers check first

Appearance
Colorless liquid
Melting point
-94.9 °C
Boiling point
110.6 °C
Density
0.8623 g/cm³ at 20 °C
Flash point
4 °C
HS code
290230
Category
Aromatics
UN number
UN 1294

What is Toluene?

Plain description, key identifiers and synonyms

Toluene is the simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent. It has a role as a non-polar solvent, a cholinergic antagonist, a neurotoxin and a fuel additive. It is a volatile organic compound, a member of toluenes and a methylbenzene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
toluene
CAS number
108-88-3 CAS number cross-checkedOther or deprecated CAS: 22904-44-5, 25013-04-1
EC numbers
203-625-9, 946-198-0
Molecular formula
C7H8
UNII
3FPU23BG52
MDL number
MFCD00008512
INCI name
TOLUENE
InChIKey
YXFVVABEGXRONW-UHFFFAOYSA-N
InChI
InChI=1S/C7H8/c1-7-5-3-2-4-6-7/h2-6H,1H3
SMILES (canonical and isomeric)
CC1=CC=CC=C1

Synonyms

  • methylbenzene
  • toluol
  • Phenylmethane
  • methacide
  • methylbenzol
  • antisal 1a
  • Benzene, methyl-
  • Toluen
  • tolu-sol
  • monomethyl benzene
  • Methane, phenyl-
  • Tolueen
  • Toluolo
  • phenyl methane
  • 1-Methylbenzene
  • RCRA waste number U220
  • Tolueno
  • methyl benzene
  • CP 25
  • Methyl benzol
  • methyl-Benzene
  • p-toluene
  • 4-methylbenzene
  • Benzene, methyl
  • UN 1294
Show all 34 synonyms
  • Toluene-3,5-d2
  • Toluene (Methyl-13C, 99%)
  • Toluene, anhydrous
  • Toluene, analytical standard
  • para-toluene
  • Toluene, ACS reagent, >=99.5%
  • Toluene 1000 microg/mL in Methanol
  • RCRA waste no. U220
  • Dracyl

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless liquidexp.
Odour
Sweet, pungent, benzene-like odorexp.
Melting point
-94.9 °Cexp.
Boiling point
110.6 °Cexp.
Density
0.8623 g/cm³ at 20 °Cexp.
Flash point
4 °Cexp.
Autoignition temperature
480 °Cexp.
Solubility
In water, 526 mg/L at 25 °Cexp.
Vapour pressure
28.4 mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
92.14 g/molcalc.
Exact mass
92.0626 Dacalc.
LogP (octanol/water)
2calc.
Topological polar surface area
0 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
0calc.
Rotatable bonds
0calc.
Heavy atoms
7calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.14calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
320NFPA 704 rating

Hazard statements

  • H225Highly flammable liquid and vapour.
  • H304May be fatal if swallowed and enters airways.
  • H315Causes skin irritation.
  • H336May cause drowsiness or dizziness.
  • H361dSuspected of damaging the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (27)
  • P203Obtain, read and follow all safety instructions before use.
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P331Do not induce vomiting.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 1294
Transport hazard class
3
Packing group
II

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Toluene suppliers

Controlled substance, listings of documented suppliers only, in the documented ranking

Drug precursor

Toluene is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Reference: UN Convention against Illicit Traffic 1988 Table II, India NDPS controlled substance, HS 2022 subheading 2902.30 (toluene)

Our policy on controlled substances
No documented supplier lists it yet

Licensed buyers can post a request for Toluene with their licence. Our compliance team reviews it before suppliers see it.

Toluene price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Toluene is a component of gasoline, paints, inks, lacquers, paint thinners, adhesives, fingernail polish, cleaning agents, and rubber. BTX (a mixture of benzene, toluene, and xylene) is added to gasoline to improve octane ratings. Toluene is used to produce benzene, trinitrotoluene (TNT), nylon, plastics, and polyurethanes.

Aviation gasoline and high-octane blending stock, benzene, phenol, and caprolactam, solvent for paints and coatings, gums, resins, most oils, rubber, vinyl organosols, diluent and thinner in nitrocellulose lacquers, adhesive solvent in plastic toys and model airplanes, chemicals (benzoic acid, benzyl and benzoyl derivatives, saccharin, medicines, dyes, perfumes), source of toluenediisocyanates (polyurethane resins), explosives (TNT), toluene sulfonates (detergents), scintillation counters.

In manufacture benzoic acid, benzaldehyde, explosives, dyes, and many other org

Read more

anic compounds, as a solvent for paints, lacquers, gums, resins, thinner for inks, perfumes, dyes, in the extraction of various principles from plants, as gasoline additive.

The major use of toluene is as a mixture added to gasoline to improve octane ratings. Toluene is also used to produce benzene and as a solvent in paints, coatings, synthetic fragrances, adhesives, inks, and cleaning agents.

Industrial uses: Diluent, Waterproofing agent, Catalyst, Reducing agent, Sealant (barrier), Plasticizer, Laboratory chemicals.

Consumer uses: Adhesion/cohesion promoter, Intermediate, Sealant (barrier), Catalyst, Corrosion inhibitor, Plasticizer, Fuel agents.

Use classes: Hydrocarbons, Volatile organic compounds, Solvents, Cosmetics, Animal Drugs.

Cosmetic ingredient, INCI name TOLUENE(antioxidant, solvent)

Pharmacological actions

  • Solvents

Roles

  • additive
  • aetiopathogenetic role
  • cholinergic antagonist
  • cholinergic drug
  • fuel additive
  • neurotoxin
  • neurotransmitter agent
  • non-polar solvent
  • pharmaceutical
  • poison
  • solvent

Functional uses

  • Adhesion/cohesion promoter
  • Antioxidant
  • Chemical reaction regulator
  • Cleaning agent
  • Fragrance
  • Propellants, non-motive (blowing agents)
  • Solubility enhancer
  • Solvent

Cosmetic functions

  • Antioxidant
  • Solvent

Pharmacology

Toluene is an aromatic hydrocarbon composed of a benzene ring linked to one methyl group. Toluene is used a solvent or as a chemical intermediate in various industrial applications. Rapid inhalation of high concentrations of toluene can cause severe neurological complications.

How it is made

It is possible to synthesize toluene industrially by alkylation of benzene with methanol, and by cyclization of n-heptane with subsequent aromatization. However, for economic reasons toluene is extracted from ... reformates from crude petroleum distillates, liquid products from the pyrolysis of hydrocarbons (steam cracking) (and) liquid products from the gasification or coking (pyrolysis) of coal, lignite, etc. ...

Read more

An important aspect of the extraction of toluene is the fact that the pyrolysis products (from steam cracking, coking, etc.) must be hydrogenated before pure toluene can be extracted. The unsaturated components are converted to saturated ones and the heteroatoms such as sulfur, nitrogen, and oxygen are removed. In the case of reformates such pretreatment is usually unnecessary. For the separation of toluene from other components within the same boiling range several methods are available, depending on quality requirements. Fine fractionation is now suitable only for the production of toluene with lower purity, and involves significant losses in fores and tails. Azeotropic distillation uses entrainers, such as methanol, to separate toluene from nonaromatics, a nonaromatics - methanol fraction with a lower bp than the methanol - toluene azeotrope distills at the column head, while pure toluene is removed from its base. Methanol is recovered from the distillate by washing with water.

Regulatory status

Inventories, regulations and trade controls that list this substance

Drug precursor

Toluene is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Reference: UN Convention against Illicit Traffic 1988 Table II, India NDPS controlled substance, HS 2022 subheading 2902.30 (toluene)

Our policy on controlled substances

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 601-021-00-3

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex III, restricted in cosmetics
    Name: TOLUENE, Ref no: 185, Annex ref: III/185

Controls

  • US DEA controlled substance or listed chemical
  • Drug precursor (UN 1988 Convention)

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Toluene is traded under.

HS 2902.30Exact HS code

Cyclic hydrocarbons: toluene

World exports in 2024
$2.38B
−12.4% vs 2023, imports $2.56B
2019 to 2024
Top exporters
  1. South Korea22.3%
  2. China19.7%
  3. Japan11.9%
Top importers
  1. United States19.1%
  2. India * partner reported15.2%
  3. South Korea15.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Toluene is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Toluene, based on the data on this page

What is Toluene?

Toluene is the simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent. It has a role as a non-polar solvent, a cholinergic antagonist, a neurotoxin and a fuel additive. It is a volatile organic compound, a member of toluenes and a methylbenzene.

What is the CAS number of Toluene?

The CAS registry number of Toluene is 108-88-3. Other or deprecated CAS numbers: 22904-44-5, 25013-04-1.

What is the molecular formula and weight of Toluene?

The molecular formula of Toluene is C7H8 and its molar mass is 92.14 g/mol.

What is Toluene used for?

Toluene is a component of gasoline, paints, inks, lacquers, paint thinners, adhesives, fingernail polish, cleaning agents, and rubber. BTX (a mixture of benzene, toluene, and xylene) is added to gasoline to improve octane ratings.

Is Toluene hazardous?

Toluene carries the GHS signal word "Danger". Main hazards: highly flammable liquid and vapour, may be fatal if swallowed and enters airways, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Toluene?

Toluene is usually classified under HS code 290230 (Toluene). This is indicative, confirm it with your customs broker before shipping.

Can I buy Toluene on CompoundList?

Toluene is a controlled substance. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed by our compliance team before suppliers see it.

Guides for buyers

Practical guides that help when you source, ship or handle Toluene

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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