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Synthetic aroma chemicals

Tonalide

Also known as Tonalid, Tetralide, AHTN

CAS 21145-77-7Formula C18H26OMolar mass 258.41 g/molEC 216-133-4
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 26 suppliers listed
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Tonalide chemical structure, C18H26O, CAS 21145-77-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White to off-white crystalline solid
Melting point
54.5 °C
Boiling point
-4 °C
Density
The relative density will be between the bulk density and its density in molten form: 60…
Solubility
In water, 1.25 mg/L, temp not specified
HS code
291439
Category
Synthetic aroma chemicals
Illustrative photo, colourless crystals beside an amber glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Tonalide?

Plain description, key identifiers and synonyms

2-Acetyl-3,5,5,6,8,8-hexamethyl-5,6,7,8- tetrahydronaphthalene is a member of tetralins.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-(3,5,5,6,8,8-hexamethyl-6,7-dihydronaphthalen-2-yl)ethanone
CAS number
21145-77-7 CAS number cross-checkedOther or deprecated CAS: 1506-02-1
EC numbers
216-133-4, 244-240-6
Molecular formula
C18H26O
UNII
360Q8Z01IP
MDL number
MFCD00437355
INCI name
ACETYL HEXAMETHYL TETRALIN
InChIKey
DNRJTBAOUJJKDY-UHFFFAOYSA-N
InChI
InChI=1S/C18H26O/c1-11-8-16-15(9-14(11)13(3)19)17(4,5)10-12(2)18(16,6)7/h8-9,12H,10H2,1-7H3
SMILES (canonical and isomeric)
CC1CC(C2=C(C1(C)C)C=C(C(=C2)C(=O)C)C)(C)C

Synonyms

  • Tonalid
  • Tetralide
  • AHTN
  • Tentarome
  • Musk tonalid
  • AHMT (perfume)
  • 2'-Acetonaphthone, 5',6',7',8'-tetrahydro-3',5',5',6',8',8'-hexamethyl-
  • 6-Acetyl-1,1,2,4,4,7-hexamethyltetralin
  • 1-(3,5,5,6,8,8-hexamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone
  • fixolide
  • Acetyl hexamethyl tetralin
  • 1-(3,5,5,6,8,8-hexamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one
  • Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)-
  • 7-Acetyl-1,1,3,4,4,6-hexamethyltetralin
  • 1-(3,5,5,6,8,8-hexamethyl-6,7-dihydronaphthalen-2-yl)ethanone
  • 6-acetyl-1,1,2,4,4,7-hexamethyltetraline
  • 1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)ethanone
  • 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)-ethanone
  • 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one
  • 2-Acetyl-3,5,5,6,8,8-hexamethyl-5,6,7,8- tetrahydronaphthalene
  • 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)ethanone
  • AHTN musk fragrance
  • 7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene
  • acetyl methyl tetramethyl tetralin
  • 1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)ethanone
Show all 36 synonyms
  • 7-Acetyl-1,1,3,4,4,6-hexamethyltetrahydronaphthalene
  • musk tetralin
  • 1-(1,1,2,4,4,7-hexamethyltetralin-6-yl)ethanone
  • Extralide
  • Tonalid(R) ii
  • AHTN 10 microg/mL in Cyclohexane
  • 1,1,3,4,4,6-Hexamethyl-7-acetyl-1,2,3,4-tetrahydronaphthalene
  • 6-Acetyl-1,1,2,4,4,7-hexamethyl-1,2,3,4-tetrahydronaphthalene
  • 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)ethan- one
  • 2'-Acetonaphthone, 5',6',7',8'-tetrahydro-3',5',5',6',8',8'-hexamethyl- (VAN)
  • Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)- (VAN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to off-white crystalline solidexp.
Odour
Odor type: muskexp.
Melting point
54.5 °Cexp.
Boiling point
-4 °Cexp.
Density
The relative density will be between the bulk density and its density in molten form: 600 < D < 960 kg/m³exp.
Solubility
In water, 1.25 mg/L, temp not specifiedexp.
Vapour pressure
5.12 × 10⁻⁴ mm Hg, temp not specifiedexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
258.41 g/molcalc.
Exact mass
258.1984 Dacalc.
LogP (octanol/water)
4.79calc.
Topological polar surface area
17.07 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
1calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCCC2

c1ccc2c(c1)CCCC2

2 rings, 10 atoms, the Tetralin ring system.

4,523 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tonalide suppliers

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Where suppliers are based

26 suppliers in 7 countries

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Tonalide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Used in soap and cosmetics.

Used as a fragrance in cosmetics, detergents, fabric softeners, household cleaning products and air fresheners.

Industrial uses: Fragrance.

Consumer uses: Fragrance.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name ACETYL HEXAMETHYL TETRALIN(fragrance, perfuming)

Functional uses

  • Deodorizer
  • Fragrance

Cosmetic functions

  • Fragrance
  • Perfuming

How it is made

It is prepared from 1,1,2,4,4,7-hexamethyltetralin, which is obtained by one of the following routes: 1. Reaction of alpha p-dimethylstyrene with tetramethylethene or 2,3-dimethylbutan-2-ol in an acetic acid-sulfuric acid mixture yields the desired hexamethyltetralin, in addition to polymerized starting materials. 2. Reaction of p-cymene with 3,3-dimethyl-l-butene (neohexene) and a tertiary alkyl halide (as a hydrogen scavenger) in the presence of catalytic amounts of anhydrous aluminum halide in inert solvents produces a high yield of the hexamethyltetralin. 1,1,2,4,4,7-Hexamethyltetralin is subsequently acetylated to 6-acetyl-1,1,2,4,4,7-hexamethyltetralin, e.g., with acetyl chloride and aluminum chloride.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex III, restricted in cosmetics
    Name: 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8,-hexamethyl-2-naphthyl)ethan-1-one (AHTN), Ref no: 182, Annex ref: III/182

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tonalide is traded under.

HS 2914.39Indicative HS code

Aromatic ketones without other oxygen function, other

World exports in 2024
$207M
−12.1% vs 2023, imports $191M
2019 to 2024
Top exporters
  1. China61.4%
  2. India * partner reported12.4%
  3. Italy7.6%
Top importers
  1. India * partner reported11.9%
  2. Germany9.9%
  3. United States8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tonalide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tonalide, based on the data on this page

What is Tonalide?

2-Acetyl-3,5,5,6,8,8-hexamethyl-5,6,7,8- tetrahydronaphthalene is a member of tetralins.

What is the CAS number of Tonalide?

The CAS registry number of Tonalide is 21145-77-7. Other or deprecated CAS numbers: 1506-02-1.

What is the molecular formula and weight of Tonalide?

The molecular formula of Tonalide is C18H26O and its molar mass is 258.41 g/mol.

What is Tonalide used for?

Used in soap and cosmetics. Used as a fragrance in cosmetics, detergents, fabric softeners, household cleaning products and air fresheners. Industrial uses: Fragrance. Consumer uses: Fragrance. Use classes: Cosmetics.

Is Tonalide hazardous?

Tonalide carries the GHS signal word "Warning". Main hazards: harmful if swallowed, very toxic to aquatic life, very toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tonalide?

Tonalide is usually classified under HS code 291439 (Aromatic ketones without other oxygen function, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tonalide?

CompoundList lists 26 suppliers of Tonalide in China, India, United States, Germany and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Tonalide in India?

6 suppliers in India list Tonalide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Tonalide?

Suppliers quote Tonalide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tonalide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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