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Cardiovascular and metabolic drugs

Torcetrapib

Also known as CP-529,414, (2R,4S)-4-((3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester, Ethyl (2R,4S)-4-((3,5-bis(trifluoromethyl)benzyl)(methoxycarbonyl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate

CAS 262352-17-0Formula C26H25F9N2O4Molar mass 600.48 g/molEC 689-436-6
GHS signal word: Warning. Pictograms: Harmful or irritant 23 suppliers listed
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Torcetrapib chemical structure, C26H25F9N2O4, CAS 262352-17-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
262352-17-0
Formula
C26H25F9N2O4
Molar mass
600.48 g/mol
EC number
689-436-6
HS code
293349
Category
Cardiovascular and metabolic drugs

What is Torcetrapib?

Plain description, key identifiers and synonyms

Torcetrapib is a carbamate ester, a member of quinolines and a member of (trifluoromethyl)benzenes. It has a role as an anticholesteremic drug and a CETP inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
CAS number
262352-17-0 CAS number cross-checkedOther or deprecated CAS: 262350-59-4
EC number
689-436-6
Molecular formula
C26H25F9N2O4
UNII
4N4457MV2U
MDL number
MFCD09260777
InChIKey
CMSGWTNRGKRWGS-NQIIRXRSSA-N
InChI
InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1
Canonical SMILES
CCOC(=O)N1c2ccc(C(F)(F)F)cc2C(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OC)CC1CC
Isomeric SMILES
CC[C@@H]1C[C@@H](C2=C(N1C(=O)OCC)C=CC(=C2)C(F)(F)F)N(CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C(=O)OC

Synonyms

  • CP-529,414
  • (2R,4S)-4-((3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
  • Ethyl (2R,4S)-4-((3,5-bis(trifluoromethyl)benzyl)(methoxycarbonyl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
  • ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
  • torcetrapibum
  • ethyl (2r,4s)-4-[[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2h)-carboxylate
  • CP529,414
  • CP 529,414
  • CP 529414
  • ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
  • (2R,4S)-ethyl 4-((3,5-bis(trifluoromethyl)benzyl)(methoxycarbonyl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
  • (2R,4S)-Rel-ethyl 4-((3,5-bis(trifluoromethyl)benzyl)(methoxycarbonyl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
  • Torcetrapib (USAN/INN)
  • Torcetrapib?
  • )-carboxylate
  • Torcetrapib, >=98% (HPLC)
  • ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonyl-amino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
  • (2R, 4S)-4-[(3,5-Bis-trifluoromethyl-benzyl)-methoxycarbonyl-amino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
  • (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H
  • Ethyl (2R,4S)-4-[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
  • ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H )-carboxylate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
600.48 g/molcalc.
Exact mass
600.1671 Dacalc.
LogP (octanol/water)
8.2calc.
Topological polar surface area
59.08 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
5calc.
Heavy atoms
41calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CNC2CCNc3ccccc32)cc1

c1ccc(CNC2CCNc3ccccc32)cc1

3 rings, 18 atoms.

7 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Torcetrapib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 23 suppliers
23 of 23 offers
  • NeoMPS SA
    FranceUnclaimed profile
    TorcetrapibGrade, purity and minimum order on request
    Price on request
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  • 1st Scientific LLC
    China, NanjingUnclaimed profile
    TorcetrapibGrade, purity and minimum order on request
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  • Aceschem Inc
    United States, FriscoUnclaimed profile
    TorcetrapibGrade, purity and minimum order on request
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  • AChemBlock
    United States, HaywardUnclaimed profile
    TorcetrapibGrade, purity and minimum order on request
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  • ACTIVATE SCIENTIFIC GmbH
    GermanyUnclaimed profile
    TorcetrapibGrade, purity and minimum order on request
    Price on request
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  • AiFChem
    United States, SomervilleUnclaimed profile
    TorcetrapibGrade, purity and minimum order on request
    Price on request
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  • Ambeed, Inc.
    United States, Buffalo GroveUnclaimed profile
    TorcetrapibGrade, purity and minimum order on request
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  • Ambinter
    France, OrleansUnclaimed profile
    TorcetrapibGrade, purity and minimum order on request
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  • Apexmol
    China, ChongqingUnclaimed profile
    TorcetrapibGrade, purity and minimum order on request
    Price on request
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  • Axon Medchem
    United States, RestonUnclaimed profile
    TorcetrapibGrade, purity and minimum order on request
    Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

23 suppliers in 6 countries

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Torcetrapib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anticholesteremic Agents

Roles

  • CETP inhibitor
  • anticholesteremic drug
  • antilipemic drug
  • cardiovascular drug
  • pharmaceutical

Pharmacology

Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to excess deaths.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Torcetrapib is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Torcetrapib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Torcetrapib, based on the data on this page

What is Torcetrapib?

Torcetrapib is a carbamate ester, a member of quinolines and a member of (trifluoromethyl)benzenes. It has a role as an anticholesteremic drug and a CETP inhibitor.

What is the CAS number of Torcetrapib?

The CAS registry number of Torcetrapib is 262352-17-0. Other or deprecated CAS numbers: 262350-59-4.

What is the molecular formula and weight of Torcetrapib?

The molecular formula of Torcetrapib is C26H25F9N2O4 and its molar mass is 600.48 g/mol.

What is Torcetrapib used for?

Known uses and roles of Torcetrapib include cardiovascular drugs in pharmaceuticals, cetp inhibitor, anticholesteremic drug, antilipemic drug, cardiovascular drug and 2 more.

Is Torcetrapib hazardous?

Torcetrapib carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Torcetrapib?

Torcetrapib is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Torcetrapib?

CompoundList lists 23 suppliers of Torcetrapib in China, United States, France, Germany and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Torcetrapib?

Suppliers quote Torcetrapib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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