CompoundList
Sign in
Oncology and immunology drugs

Trabectedin

Also known as Yondelis, Ecteinascidin, ecteinascidin 743

CAS 114899-77-3Formula C39H43N3O11SMolar mass 761.85 g/molEC 695-026-8
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 69 suppliers listed Drug substance
Get quotes Compare 69 suppliers
Trabectedin chemical structure, C39H43N3O11S, CAS 114899-77-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
114899-77-3
Formula
C39H43N3O11S
Molar mass
761.85 g/mol
EC number
695-026-8
HS code
293980
Category
Oncology and immunology drugs

What is Trabectedin?

Plain description, key identifiers and synonyms

Trabectedin is a tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer. It has a role as an alkylating agent, an antineoplastic agent, an angiogenesis modulating agent, an anti-inflammatory agent and a marine metabolite. It is an organic sulfide, an isoquinoline alkaloid, a lactone, a polyphenol, an azaspiro compound, a bridged compound, an oxaspiro compound, an organic heteropolycyclic compound, an acetate ester, a tertiary amino compound and a hemiaminal.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(1R,2R,3R,11S,12S,14R,26R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-3,4-dihydro-2H-isoquinoline]-22-yl] acetate
CAS number
114899-77-3 CAS number cross-checked
EC number
695-026-8
Molecular formula
C39H43N3O11S
UNII
ID0YZQ2TCP
InChIKey
PKVRCIRHQMSYJX-AIFWHQITSA-N
InChI
InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1
Canonical SMILES
COc1cc2c(cc1O)CCNC21CSC2c3c(OC(C)=O)c(C)c4c(c3C(COC1=O)N1C(O)C3Cc5cc(C)c(OC)c(O)c5C(C21)N3C)OCO4
Isomeric SMILES
CC1=CC2=C([C@@H]3[C@@H]4[C@H]5C6=C(C(=C7C(=C6[C@@H](N4[C@H]([C@H](C2)N3C)O)COC(=O)[C@@]8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O

Synonyms

  • Yondelis
  • Ecteinascidin
  • ecteinascidin 743
  • Et 743
  • Ect 743
  • trabectedine
  • trabectedinum
  • Trabectedina
  • Ecteinascidins trabectedin
  • Ecteinascidine 743
  • Ecteinascidin-743
  • Ecteinascidin 743, ET-743
  • Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
761.85 g/molcalc.
Exact mass
761.2618 Dacalc.
LogP (octanol/water)
3.41calc.
Topological polar surface area
168.7 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
15calc.
Rotatable bonds
3calc.
Heavy atoms
54calc.
Rings
10calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.49calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1OCC2c3c(ccc4c3OCO4)C(SCC13NCCc1ccccc13)C1C3NC(Cc4ccccc43)CN21

O=C1OCC2c3c(ccc4c3OCO4)C(SCC13NCCc1ccccc13)C1C3NC(Cc4ccccc43)CN21

10 rings, 40 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H300Fatal if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H340May cause genetic defects.
  • H341Suspected of causing genetic defects.
  • H361Suspected of damaging fertility or the unborn child.
  • H361fdSuspected of damaging fertility. Suspected of damaging the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (18)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Trabectedin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 69 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

69 suppliers in 13 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Trabectedin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents, Alkylating

Roles

  • aetiopathogenetic role
  • alkylating agent
  • angiogenesis modulating agent
  • anti-inflammatory agent
  • antineoplastic agent
  • genotoxin
  • marine metabolite
  • metabolite
  • mutagen
  • pharmaceutical

Pharmacology

Trabectedin is an Alkylating Drug. The mechanism of action of trabectedin is as an Alkylating Activity.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trabectedin is traded under.

HS 2939.80Indicative HS code

Natural or reproduced by synthesis, and their salts, esters and other derivatives not elsewhere classified…

World exports in 2024
$49.3M
+13.2% vs 2023, imports $61.4M
2019 to 2024
Top exporters
  1. China31.7%
  2. India * partner reported23.1%
  3. South Africa7.8%
Top importers
  1. Austria28.6%
  2. United States11.9%
  3. United Kingdom7.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Trabectedin is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trabectedin, based on the data on this page

What is Trabectedin?

Trabectedin is a tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.

What is the CAS number of Trabectedin?

The CAS registry number of Trabectedin is 114899-77-3.

What is the molecular formula and weight of Trabectedin?

The molecular formula of Trabectedin is C39H43N3O11S and its molar mass is 761.85 g/mol.

What is Trabectedin used for?

Known uses and roles of Trabectedin include anticancer drugs in pharmaceuticals, polymer antioxidants in plastics and polymers, aetiopathogenetic role, alkylating agent, angiogenesis modulating agent and 8 more.

Is Trabectedin hazardous?

Trabectedin carries the GHS signal word "Danger". Main hazards: fatal if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Trabectedin?

Trabectedin is usually classified under HS code 293980 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trabectedin?

CompoundList lists 69 suppliers of Trabectedin in United States, China, Germany, United Kingdom and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Trabectedin in India?

3 suppliers in India list Trabectedin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Trabectedin?

Suppliers quote Trabectedin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trabectedin

Get quotes for Trabectedin

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Trabectedin
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Trabectedin with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/trabectedin-114899-77-3" title="Trabectedin structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Oncology and immunology drugs or HS code 293980

69 suppliers
Free quotes, contact stays private
Get quotes