Tramadol hydrochloride
Also known as Tradonal, Tramadol HCl, Amadol
Key facts
What buyers check first
- CAS number
- 36282-47-0
- Formula
- C16H26ClNO2
- Molar mass
- 299.84 g/mol
- EC number
- 252-950-2
- HS code
- 292250
- Category
- Analgesics and anti-inflammatories
What is Tramadol hydrochloride?
Plain description, key identifiers and synonyms
(R,R)-tramadol hydrochloride is a hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride, the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as an opioid analgesic, an adrenergic uptake inhibitor, a serotonergic antagonist, a muscarinic antagonist, a nicotinic antagonist, a serotonin uptake inhibitor, an antitussive, a mu-opioid receptor agonist, a kappa-opioid receptor agonist, a NMDA receptor antagonist, a delta-opioid receptor agonist and a capsaicin receptor antagonist. It contains a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol hydrochloride.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- cis-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol, hydrochloride
- CAS number
- 36282-47-0 CAS number cross-checkedOther or deprecated CAS: 148229-78-1, 194602-08-9, 22204-88-2, 53611-16-8
- EC numbers
- 252-950-2, 258-662-3, 683-089-4
- Molecular formula
- C16H26ClNO2
- UNII
- 9N7R477WCK, A4RS6N53PN
- MDL number
- MFCD00798507
- InChIKey
- PPKXEPBICJTCRU-XMZRARIVSA-N
- InChI
- InChI=1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m1./s1
- Canonical SMILES
- COc1cccc(C2(O)CCCCC2CN(C)C)c1.Cl
- Isomeric SMILES
- CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O.Cl
Synonyms
- Tradonal
- Tramadol HCl
- Amadol
- Mabron
- Zydol
- ConZip
- Synapryn
- Ryzolt
- Ultram ER
- Rybix ODT
- Zamudol
- Zertane
- QDOLO
- Tramadol hydrochloride civ
- U-26,225A
- Oldaram
- Zamadol
- Durela
- Maneo
- Marol
- Tramake insts
- Dromadol sr
- Dromadol xl
- Maxitram sr
- Nobligan ret
Show all 39 synonymsShow fewer synonyms
- Tradorec xl
- Tramquel sr
- Tramulief sr
- Zamadol melt
- Zeridame sr
- Invodol sr
- Larapam sr
- Tilodol sr
- Zamadol sr
- Zydol sr
- Zydol xl
- Tramadol ER
- Tramadol HCL ER
- Zamadol 24hr
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 299.84 g/molcalc.Computed value |
|---|---|
| Exact mass | 299.1652 Dacalc.Computed value |
| LogP (octanol/water) | 3.06calc.Computed value |
| Topological polar surface area | 32.7 Ųcalc.Computed value |
| Hydrogen bond donors | 1calc.Computed value |
| Hydrogen bond acceptors | 3calc.Computed value |
| Rotatable bonds | 4calc.Computed value |
| Heavy atoms | 20calc.Computed value |
| Rings | 2calc.Computed value |
| Aromatic rings | 1calc.Computed value |
| Fraction sp3 carbons | 0.63calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 2calc.Computed value |
| Components | 2calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
c1ccc(C2CCCCC2)cc1
2 rings, 12 atoms, the Cyclohexylbenzene ring system.
4,255 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H301Toxic if swallowed.
- H302Harmful if swallowed.
- H411Toxic to aquatic life with long lasting effects.
Precautionary statements (10)
- P264Wash skin thoroughly after handling.
- P270Do not eat, drink or smoke when using this product.
- P273Avoid release to the environment.
- P301 + P316If swallowed: Get emergency medical help immediately.
- P301 + P317If swallowed: Get medical help.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P330Rinse mouth.
- P391Collect spillage.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidTramadol hydrochloride suppliers
Controlled substance, listings of documented suppliers only, in the documented ranking
Tramadol hydrochloride is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.
Our policy on controlled substancesLicensed buyers can post a request for Tramadol hydrochloride with their licence. Our compliance team reviews it before suppliers see it.
Tramadol hydrochloride price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Industries and functions
Roles
- NMDA receptor antagonist
- adrenergic agent
- adrenergic uptake inhibitor
- analgesic
- antineoplastic agent
- antitussive
- capsaicin receptor antagonist
- cholinergic antagonist
- cholinergic drug
- delta-opioid agent
- delta-opioid receptor agonist
- kappa-opioid agent
- kappa-opioid receptor agonist
- mu-opioid receptor agonist
- muscarinic antagonist
- neurotransmitter agent
- nicotinic antagonist
- opioid agent
- opioid analgesic
- opioid receptor agonist
- pharmaceutical
- serotonergic antagonist
- serotonergic drug
- serotonin uptake inhibitor
Pharmacology
Tramadol Hydrochloride is a synthetic codeine analogue, Tramadol Hydrochloride has central analgesic properties with effects similar to opioids, such as morphine and codeine, acting on specific opioid receptors. The hydrochloride salt of Tramadol and used as a narcotic analgesic for severe pain, it can be addictive and weakly inhibits norepinephrine and serotonin reuptake. (NCI04)
Regulatory status
Inventories, regulations and trade controls that list this substance
Tramadol hydrochloride is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.
Our policy on controlled substancesHealth and food
- Active ingredient in FDA approved drug labels
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Tramadol hydrochloride is traded under.
Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function
- China39.2%
- United Kingdom27.1%
- India * partner reported4.8%
- United States20.7%
- Germany7.6%
- Italy6.6%
* Partner reported figures, a lower bound.
The HS code shown for Tramadol hydrochloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about Tramadol hydrochloride, based on the data on this page
What is Tramadol hydrochloride?
What is the CAS number of Tramadol hydrochloride?
What is the molecular formula and weight of Tramadol hydrochloride?
What is Tramadol hydrochloride used for?
Is Tramadol hydrochloride hazardous?
What is the HS code of Tramadol hydrochloride?
Can I buy Tramadol hydrochloride on CompoundList?
Guides for buyers
Practical guides that help when you source, ship or handle Tramadol hydrochloride
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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