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Tramadol hydrochloride chemical structure, C16H26ClNO2, CAS 36282-47-0
2D chemical structure

Key facts

What buyers check first

CAS number
36282-47-0
Formula
C16H26ClNO2
Molar mass
299.84 g/mol
EC number
252-950-2
HS code
292250
Category
Analgesics and anti-inflammatories

What is Tramadol hydrochloride?

Plain description, key identifiers and synonyms

(R,R)-tramadol hydrochloride is a hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride, the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as an opioid analgesic, an adrenergic uptake inhibitor, a serotonergic antagonist, a muscarinic antagonist, a nicotinic antagonist, a serotonin uptake inhibitor, an antitussive, a mu-opioid receptor agonist, a kappa-opioid receptor agonist, a NMDA receptor antagonist, a delta-opioid receptor agonist and a capsaicin receptor antagonist. It contains a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol hydrochloride.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
cis-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol, hydrochloride
CAS number
36282-47-0 CAS number cross-checkedOther or deprecated CAS: 148229-78-1, 194602-08-9, 22204-88-2, 53611-16-8
EC numbers
252-950-2, 258-662-3, 683-089-4
Molecular formula
C16H26ClNO2
UNII
9N7R477WCK, A4RS6N53PN
MDL number
MFCD00798507
InChIKey
PPKXEPBICJTCRU-XMZRARIVSA-N
InChI
InChI=1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m1./s1
Canonical SMILES
COc1cccc(C2(O)CCCCC2CN(C)C)c1.Cl
Isomeric SMILES
CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O.Cl

Synonyms

  • Tradonal
  • Tramadol HCl
  • Amadol
  • Mabron
  • Zydol
  • ConZip
  • Synapryn
  • Ryzolt
  • Ultram ER
  • Rybix ODT
  • Zamudol
  • Zertane
  • QDOLO
  • Tramadol hydrochloride civ
  • U-26,225A
  • Oldaram
  • Zamadol
  • Durela
  • Maneo
  • Marol
  • Tramake insts
  • Dromadol sr
  • Dromadol xl
  • Maxitram sr
  • Nobligan ret
Show all 39 synonyms
  • Tradorec xl
  • Tramquel sr
  • Tramulief sr
  • Zamadol melt
  • Zeridame sr
  • Invodol sr
  • Larapam sr
  • Tilodol sr
  • Zamadol sr
  • Zydol sr
  • Zydol xl
  • Tramadol ER
  • Tramadol HCL ER
  • Zamadol 24hr

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
299.84 g/molcalc.
Exact mass
299.1652 Dacalc.
LogP (octanol/water)
3.06calc.
Topological polar surface area
32.7 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.63calc.
Formal charge
0calc.
Stereocentres
2calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(C2CCCCC2)cc1

c1ccc(C2CCCCC2)cc1

2 rings, 12 atoms, the Cyclohexylbenzene ring system.

4,255 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (10)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tramadol hydrochloride suppliers

Controlled substance, listings of documented suppliers only, in the documented ranking

Controlled or monitored substance

Tramadol hydrochloride is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Our policy on controlled substances
No documented supplier lists it yet

Licensed buyers can post a request for Tramadol hydrochloride with their licence. Our compliance team reviews it before suppliers see it.

Tramadol hydrochloride price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • NMDA receptor antagonist
  • adrenergic agent
  • adrenergic uptake inhibitor
  • analgesic
  • antineoplastic agent
  • antitussive
  • capsaicin receptor antagonist
  • cholinergic antagonist
  • cholinergic drug
  • delta-opioid agent
  • delta-opioid receptor agonist
  • kappa-opioid agent
  • kappa-opioid receptor agonist
  • mu-opioid receptor agonist
  • muscarinic antagonist
  • neurotransmitter agent
  • nicotinic antagonist
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical
  • serotonergic antagonist
  • serotonergic drug
  • serotonin uptake inhibitor

Pharmacology

Tramadol Hydrochloride is a synthetic codeine analogue, Tramadol Hydrochloride has central analgesic properties with effects similar to opioids, such as morphine and codeine, acting on specific opioid receptors. The hydrochloride salt of Tramadol and used as a narcotic analgesic for severe pain, it can be addictive and weakly inhibits norepinephrine and serotonin reuptake. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

Controlled or monitored substance

Tramadol hydrochloride is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Our policy on controlled substances

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tramadol hydrochloride is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tramadol hydrochloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tramadol hydrochloride, based on the data on this page

What is Tramadol hydrochloride?

(R,R)-tramadol hydrochloride is a hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride, the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.

What is the CAS number of Tramadol hydrochloride?

The CAS registry number of Tramadol hydrochloride is 36282-47-0. Other or deprecated CAS numbers: 148229-78-1, 194602-08-9, 22204-88-2.

What is the molecular formula and weight of Tramadol hydrochloride?

The molecular formula of Tramadol hydrochloride is C16H26ClNO2 and its molar mass is 299.84 g/mol.

What is Tramadol hydrochloride used for?

Known uses and roles of Tramadol hydrochloride include analgesics and antipyretics in pharmaceuticals, cns agents in pharmaceuticals, nmda receptor antagonist, adrenergic agent, adrenergic uptake inhibitor and 21 more.

Is Tramadol hydrochloride hazardous?

Tramadol hydrochloride carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tramadol hydrochloride?

Tramadol hydrochloride is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Can I buy Tramadol hydrochloride on CompoundList?

Tramadol hydrochloride is a controlled substance. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed by our compliance team before suppliers see it.

Guides for buyers

Practical guides that help when you source, ship or handle Tramadol hydrochloride

Request as a licensed buyer

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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