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Oncology and immunology drugs

Treosulfan

Also known as Treosulphan, Ovastat, Dihydroxybusulfan

CAS 299-75-2Formula C6H14O8S2Molar mass 278.30 g/molEC 206-081-0
GHS signal word: Danger. Pictograms: Serious health hazard 35 suppliers listed Drug substance
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Treosulfan chemical structure, C6H14O8S2, CAS 299-75-2
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Powder
Melting point
102.2 °C
Solubility
Greater than or equal to 100 mg/mL at 66 °F
HS code
290559
Category
Oncology and immunology drugs
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Treosulfan?

Plain description, key identifiers and synonyms

Treosulfan is a methanesulfonate ester.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(2S,3S)-2,3-dihydroxy-4-methylsulfonyloxybutyl] methanesulfonate
CAS number
299-75-2 CAS number cross-checkedOther or deprecated CAS: 21106-06-9
EC number
206-081-0
Molecular formula
C6H14O8S2
UNII
CO61ER3EPI
MDL number
MFCD02258964
InChIKey
YCPOZVAOBBQLRI-WDSKDSINSA-N
InChI
InChI=1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1
Canonical SMILES
CS(=O)(=O)OCC(O)C(O)COS(C)(=O)=O
Isomeric SMILES
CS(=O)(=O)OC[C@@H]([C@H](COS(=O)(=O)C)O)O

Synonyms

  • Treosulphan
  • Ovastat
  • Dihydroxybusulfan
  • threosulphan
  • Trecondi
  • Treosulfano
  • Tresulfan
  • L-Threitol 1,4-dimethanesulfonate
  • Treosulfanum
  • Grafapex
  • (2S,3S)-Threitol 1,4-bismethanesulfonate
  • Dihydroxymyleran
  • L-Threityl dimesylate
  • Graftrevo
  • Kepcondi
  • L-Threitol, 1,4-bis(methanesulfonate)
  • Trecondyv
  • Treograft
  • L-dihydroxybusulfan
  • Threitol, 1,4-dimethanesulfonate, (2S,3S)-
  • CB 2562
  • L-Threitol 1,4-dimethanesulphonate
  • (S-(R*,R*))-1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate
  • (2S,3S)-2,3-dihydroxy-4-(methanesulfonyloxy)butyl methanesulfonate
  • L-threitol-1,4-bismethanesulfonate
Show all 35 synonyms
  • Threitol, 1,4-dimethanesulfonate
  • Tresulfon
  • (2,3-dihydroxy-4-methylsulfonyloxybutyl) methanesulfonate
  • (S-(R*,R*))-1,2,3,4-butanetetrol,1,4-dimethanesulfonate
  • 1,2,3, 4-Butanetetrol, 1,4-dimethanesulfonate, (R-(R*,S*))-
  • (2S,3S)-2,3-dihydroxybutane-1,4-diyl dimethanesulfonate
  • l-Threitol-1,4-bis(methanesulfonate)
  • Treosulfan (INN)
  • [(2S,3S)-2,3-dihydroxy-4-methylsulfonyloxybutyl] methanesulfonate
  • CB 40067

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Powderexp.
Melting point
102.2 °Cexp.
Solubility
Greater than or equal to 100 mg/mL at 66 °Fexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
278.30 g/molcalc.
Exact mass
278.013 Dacalc.
LogP (octanol/water)
-2.34calc.
Topological polar surface area
127.2 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
7calc.
Heavy atoms
16calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H340May cause genetic defects.
  • H350May cause cancer.
  • H361fSuspected of damaging fertility.
  • H371May cause damage to organs.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Treosulfan suppliers

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All 35 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

35 suppliers in 12 countries

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Treosulfan price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Antineoplastic.

Treosulfan is a bifunctional alkylating prodrug with activity against various solid tumors.

Industries and functions

Pharmacological actions

  • Antineoplastic Agents, Alkylating

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Treosulfan is the prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppressive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhibits myeloablative and immunosuppressive activities.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Treosulfan is traded under.

HS 2905.59Indicative HS code

Halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols, other

World exports in 2024
$210M
+1.6% vs 2023, imports $201M
2019 to 2024
Top exporters
  1. China43.9%
  2. Germany11.6%
  3. Spain6.9%
Top importers
  1. Germany17.1%
  2. United States13.4%
  3. India * partner reported12.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Treosulfan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Treosulfan, based on the data on this page

What is Treosulfan?

Treosulfan is a methanesulfonate ester.

What is the CAS number of Treosulfan?

The CAS registry number of Treosulfan is 299-75-2. Other or deprecated CAS numbers: 21106-06-9.

What is the molecular formula and weight of Treosulfan?

The molecular formula of Treosulfan is C6H14O8S2 and its molar mass is 278.30 g/mol.

What is Treosulfan used for?

Antineoplastic. Treosulfan is a bifunctional alkylating prodrug with activity against various solid tumors.

Is Treosulfan hazardous?

Treosulfan carries the GHS signal word "Danger". Main hazards: may cause genetic defects, may cause cancer, suspected of damaging fertility. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Treosulfan?

Treosulfan is usually classified under HS code 290559 (Halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Treosulfan?

CompoundList lists 35 suppliers of Treosulfan in United States, China, Hong Kong, India and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Treosulfan in India?

2 suppliers in India list Treosulfan on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Treosulfan?

Suppliers quote Treosulfan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Treosulfan

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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