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Cardiovascular and metabolic drugs

Trichlormethiazide

Also known as Trichloromethiazide, Naqua, Metahydrin

CAS 133-67-5Formula C8H8Cl3N3O4S2Molar mass 380.66 g/molEC 205-118-8
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 69 suppliers listed Drug substance
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Trichlormethiazide chemical structure, C8H8Cl3N3O4S2, CAS 133-67-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
133-67-5
Formula
C8H8Cl3N3O4S2
Appearance
Crystals from methanol + acetone + water
Solubility
@ 25 °C: 0.8 MG/ML IN WATER, 21 MG/ML IN ETHANOL, 60 MG/ML IN METHANOL
HS code
293590
Category
Cardiovascular and metabolic drugs
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Trichlormethiazide?

Plain description, key identifiers and synonyms

Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide antibiotic.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
CAS number
133-67-5 CAS number cross-checked
EC number
205-118-8
Molecular formula
C8H8Cl3N3O4S2
UNII
Q58C92TUN0
MDL number
MFCD00057315
InChIKey
LMJSLTNSBFUCMU-UHFFFAOYSA-N
InChI
InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
SMILES (canonical and isomeric)
C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)NC(N2)C(Cl)Cl

Synonyms

  • Trichloromethiazide
  • Naqua
  • Metahydrin
  • Trichlormetazid
  • Trichlormethiazid
  • Diurazida
  • Trichlorex
  • Diuroral
  • Esmarin
  • Fluitran
  • Gangesol
  • Hydrotrichlorothiazide
  • Flutra
  • Nakva
  • Triclordiuride
  • Trichlormas
  • Triflumen
  • Eurinol
  • Triclormetiazida
  • Triclormetiazide
  • Trichloromethiadiazide
  • Ciba 7057-Su
  • Trichlordiuride
  • Salurin (wadel)
  • Trichlormethiazidum
Show all 38 synonyms
  • 3-Dichloromethylhydrochlorothiazide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
  • 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
  • 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
  • 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^(6),2,4-benzothiadiazine-7-sulfonamide
  • (3RS)-6-Chloro-3-dichloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • Intromene
  • Achletin
  • Aponorin
  • Cretonin
  • Chlopolidine
  • Isestran

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from methanol + acetone + waterexp.
Odour
ODORLESS OR HAS SLIGHT CHARACTERISTIC ODORexp.
Solubility
@ 25 °C: 0.8 MG/ML IN WATER, 21 MG/ML IN ETHANOL, 60 MG/ML IN METHANOLexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
380.66 g/molcalc.
Exact mass
378.9022 Dacalc.
LogP (octanol/water)
0.82calc.
Topological polar surface area
118.4 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S1(=O)NCNc2ccccc21

O=S1(=O)NCNc2ccccc21

2 rings, 12 atoms, the 2H-1,2,4-Benzothiadiazine, 3,4-dihydro-, 1,1-dioxide ring system.

123 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H317May cause an allergic skin reaction.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary statements (15)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Trichlormethiazide suppliers

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Where suppliers are based

69 suppliers in 14 countries

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Trichlormethiazide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Diuretic, antihypertensive, THERAP CAT (VET): Diuretic.

Use classes: Pharmaceuticals, Animal Drugs.

Industries and functions

Pharmacological actions

  • Antihypertensive Agents
  • Diuretics
  • Sodium Chloride Symporter Inhibitors

Roles

  • antihypertensive agent
  • cardiovascular drug
  • diuretic
  • pharmaceutical

Pharmacology

Trichlormethiazide is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics.

How it is made

Destevens et al, experientia 16, 113 (1960), sherlock et al, experientia 16 184 (1960).

By reacting 4-amino-6-chloro-m-benzene-disulfonamide with dichloroacetaldehyde, or acetal thereof, in suitable condensation environment. Us patents 3,163,645 & 3,264,292.

Chloral + 5-chloroaniline-2,4-disulfonamide (carbonyl condensation).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trichlormethiazide is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Trichlormethiazide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trichlormethiazide, based on the data on this page

What is Trichlormethiazide?

Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide.

What is the CAS number of Trichlormethiazide?

The CAS registry number of Trichlormethiazide is 133-67-5.

What is the molecular formula and weight of Trichlormethiazide?

The molecular formula of Trichlormethiazide is C8H8Cl3N3O4S2 and its molar mass is 380.66 g/mol.

What is Trichlormethiazide used for?

Therapeutic category: Diuretic, antihypertensive, THERAP CAT (VET): Diuretic. Use classes: Pharmaceuticals, Animal Drugs.

Is Trichlormethiazide hazardous?

Trichlormethiazide carries the GHS signal word "Danger". Main hazards: may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Trichlormethiazide?

Trichlormethiazide is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trichlormethiazide?

CompoundList lists 69 suppliers of Trichlormethiazide in United States, China, United Kingdom, Canada and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Trichlormethiazide?

Suppliers quote Trichlormethiazide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trichlormethiazide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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