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Oncology and immunology drugs

Trilostane

Also known as Modrenal, Desopan, Vetoryl

CAS 13647-35-3Formula C20H27NO3Molar mass 329.44 g/molEC 237-133-0
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 66 suppliers listed Drug substance
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Trilostane chemical structure, C20H27NO3, CAS 13647-35-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
13647-35-3
Formula
C20H27NO3
Molar mass
329.44 g/mol
EC number
237-133-0
HS code
292690
Category
Oncology and immunology drugs

What is Trilostane?

Plain description, key identifiers and synonyms

Trilostane is an epoxy steroid that is 3,17beta-dihydroxy-5alpha-androst-2-ene-2-carbonitrile in which the oxygen of the epoxy group is joined to the 4alpha and 5 alpha positions. It has a role as an antineoplastic agent, an abortifacient and an EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor. It is an epoxy steroid, a nitrile, a 17beta-hydroxy steroid, a 3-hydroxy steroid and an androstanoid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.02,8.06,8.012,16]octadec-4-ene-4-carbonitrile
CAS number
13647-35-3 CAS number cross-checked
EC number
237-133-0
Molecular formula
C20H27NO3
UNII
L0FPV48Q5R
MDL number
MFCD00199295
InChIKey
KVJXBPDAXMEYOA-CXANFOAXSA-N
InChI
InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
Canonical SMILES
CC12CCC3C(CCC45OC4C(O)=C(C#N)CC35C)C1CCC2O
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CC[C@]45[C@@]3(CC(=C([C@H]4O5)O)C#N)C

Synonyms

  • Modrenal
  • Desopan
  • Vetoryl
  • Modrastane
  • Trilostano
  • Trilostanum
  • WIN 24,540
  • Win 24540
  • Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4alpha,5alpha,17beta)-
  • (1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.0^{2,8}.0^{6,8}.0^{12,16}]octadec-4-ene-4-carbonitrile
  • (1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo(9.7.0.0^(2,8).0^(6,8).0^(12,16))octadec-4-ene-4-carbonitrile
  • Vetoryl capsules
  • 4alpha,5-epoxy-17beta-hydroxy-3-oxoandrostane-2-carbonitrile
  • 2Alpha-cyano-4alpha,5alpha-epoxyandrostan-17beta-ol-3-one
  • (4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile
  • 4,5-Epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile
  • (1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.02,8.06,8.012,16]octadec-4-ene-4-carbonitrile
  • 4alpha,5-Epoxy-3,17beta-dihydroxy-5alpha-androst-2-ene-2-carbonitrile
  • Modrenal (TN)
  • Desopan (TN)
  • Trilostane (JAN/USAN)
  • (4alpha,5alpha,17beta)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
  • WIN 24450
  • Trilostane (Standard)
  • Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4a,5a,17b)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
329.44 g/molcalc.
Exact mass
329.1991 Dacalc.
LogP (octanol/water)
3.47calc.
Topological polar surface area
76.78 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
0calc.
Heavy atoms
24calc.
Rings
5calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.85calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CC2OC23CCC2C4CCCC4CCC2C3C1

C1=CC2OC23CCC2C4CCCC4CCC2C3C1

5 rings, 18 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (13)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Trilostane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 66 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

66 suppliers in 12 countries

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Trilostane price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Animal Drugs.

Pharmacological actions

  • Abortifacient Agents, Steroidal
  • Antineoplastic Agents
  • Enzyme Inhibitors

Roles

  • abortifacient
  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical
  • reproductive control drug

Pharmacology

Trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trilostane is traded under.

HS 2926.90Indicative HS code

Nitrile-function compounds, other

World exports in 2024
$2.15B
−13.5% vs 2023, imports $2.17B
2019 to 2024
Top exporters
  1. China35.6%
  2. France * partner reported12.7%
  3. India * partner reported11.2%
Top importers
  1. United States13.6%
  2. China12.4%
  3. Brazil11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Trilostane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trilostane, based on the data on this page

What is Trilostane?

Trilostane is an epoxy steroid that is 3,17beta-dihydroxy-5alpha-androst-2-ene-2-carbonitrile in which the oxygen of the epoxy group is joined to the 4alpha and 5 alpha positions. It has a role as an antineoplastic agent, an abortifacient and an EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor.

What is the CAS number of Trilostane?

The CAS registry number of Trilostane is 13647-35-3.

What is the molecular formula and weight of Trilostane?

The molecular formula of Trilostane is C20H27NO3 and its molar mass is 329.44 g/mol.

What is Trilostane used for?

Use classes: Animal Drugs.

Is Trilostane hazardous?

Trilostane carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Trilostane?

Trilostane is usually classified under HS code 292690 (Nitrile-function compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trilostane?

CompoundList lists 66 suppliers of Trilostane in China, United States, Hong Kong, Canada and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Trilostane?

Suppliers quote Trilostane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trilostane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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