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Oncology and immunology drugs

Trimetrexate

Also known as Trimetrexato, Trimetrexatum, 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine

CAS 52128-35-5Formula C19H23N5O3Molar mass 369.43 g/mol
8 suppliers listed
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Trimetrexate chemical structure, C19H23N5O3, CAS 52128-35-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
52128-35-5
Formula
C19H23N5O3
Molar mass
369.43 g/mol
Solubility
Tan colored solid, solubility in water: > 50 mg/ml /Trimetrexate D-glucuronate/
HS code
293359
Category
Oncology and immunology drugs

What is Trimetrexate?

Plain description, key identifiers and synonyms

Trimetrexate is a member of quinazolines. It has a role as an antifungal drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine
CAS number
52128-35-5 CAS number cross-checkedOther or deprecated CAS: 251301-18-5, 72828-03-6
Molecular formula
C19H23N5O3
UNII
UPN4ITI8T4
MDL number
MFCD00866404
InChIKey
NOYPYLRCIDNJJB-UHFFFAOYSA-N
InChI
InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)
SMILES (canonical and isomeric)
CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC

Synonyms

  • Trimetrexato
  • Trimetrexatum
  • 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine
  • 2,4-Diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline
  • 5-Methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-2,4-quinazolinediamine
  • 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)quinazoline-2,4-diamine
  • 2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-
  • 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine
  • 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline
  • Trimexate
  • Hydrate, Trimetrexate
  • Monohydrate, Monoacetate Trimetrexate
  • Jb-11
  • TMQ
  • 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine
  • 2,4-Quinazolinediamine,5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-
  • JB 11
  • Trimetrexate Hydrate
  • Trimetrexate (USAN/INN)
  • 6-[((3,4,5-Trimethoxyphenyl)amino)methyl]-5-methyl-2,4-quinazolinediamine
  • 5-methyl-6-({[3,4,5-tris(methyloxy)phenyl]amino}methyl)quinazoline-2,4-diamine
  • 2, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-
  • 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyphenylamino)methyl]quinazoline

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
Tan colored solid, solubility in water: > 50 mg/ml /Trimetrexate D-glucuronate/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
369.43 g/molcalc.
Exact mass
369.1801 Dacalc.
LogP (octanol/water)
2.74calc.
Topological polar surface area
117.5 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
6calc.
Heavy atoms
27calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(NCc2ccc3ncncc3c2)cc1

c1ccc(NCc2ccc3ncncc3c2)cc1

3 rings, 18 atoms.

47 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Trimetrexate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 8 suppliers
8 of 8 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

8 suppliers in 2 countries

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Trimetrexate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antifungal Agents
  • Antimetabolites, Antineoplastic
  • Folic Acid Antagonists

Roles

  • antiamoebic agent
  • antifungal agent
  • antifungal drug
  • antiinfective agent
  • antimicrobial agent
  • antiparasitic agent
  • pharmaceutical

Pharmacology

Trimetrexate is a methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate also exhibits antiviral activity. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trimetrexate is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Trimetrexate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trimetrexate, based on the data on this page

What is Trimetrexate?

Trimetrexate is a member of quinazolines. It has a role as an antifungal drug.

What is the CAS number of Trimetrexate?

The CAS registry number of Trimetrexate is 52128-35-5. Other or deprecated CAS numbers: 251301-18-5, 72828-03-6.

What is the molecular formula and weight of Trimetrexate?

The molecular formula of Trimetrexate is C19H23N5O3 and its molar mass is 369.43 g/mol.

What is Trimetrexate used for?

Known uses and roles of Trimetrexate include antifungals in pharmaceuticals, anticancer drugs in pharmaceuticals, antiamoebic agent, antifungal agent, antifungal drug and 7 more.

Is Trimetrexate hazardous?

No GHS hazard classification for Trimetrexate is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Trimetrexate?

Trimetrexate is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trimetrexate?

CompoundList lists 8 suppliers of Trimetrexate in India and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Trimetrexate in India?

6 suppliers in India list Trimetrexate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Trimetrexate?

Suppliers quote Trimetrexate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trimetrexate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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