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Respiratory, allergy and digestive drugs

Triprolidine

Also known as Triprolidin, Actidil, Tripolidina

CAS 486-12-4Formula C19H22N2Molar mass 278.40 g/molEC 207-627-0
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Triprolidine chemical structure, C19H22N2, CAS 486-12-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
486-12-4
Formula
C19H22N2
Appearance
Crystals from light petroleum
Melting point
59 to 61 °C
HS code
293339
Category
Respiratory, allergy and digestive drugs
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Triprolidine?

Plain description, key identifiers and synonyms

Triprolidine is an N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders. It has a role as a H1-receptor antagonist. It is a member of pyridines, a N-alkylpyrrolidine and an olefinic compound. It is a conjugate base of a triprolidine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
CAS number
486-12-4 CAS number cross-checked
EC number
207-627-0
Molecular formula
C19H22N2
UNII
2L8T9S52QM
InChIKey
CBEQULMOCCWAQT-WOJGMQOQSA-N
InChI
InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
Canonical SMILES
Cc1ccc(C(=CCN2CCCC2)c2ccccn2)cc1
Isomeric SMILES
CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3

Synonyms

  • Triprolidin
  • Actidil
  • Tripolidina
  • Triprolidinum
  • Triprolidina
  • 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
  • trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene
  • trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene
  • 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine
  • Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, (E)-
  • trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine
  • (E)-2-[3-(1-Pyrrolidinyl)-1-p-toluenepropenyl]pyridine
  • (E)-2-(3-(1-pyrrolidinyl)-1-p-toluenepropenyl)pyridine
  • 2-((E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl)pyridine
  • 2-((1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl)pyridine
  • Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, (E)-
  • Histafed
  • Triprolidine (INN)
  • (E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine
  • (E)-2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine
  • Sdccgsbi-0025383.p005
  • 2-(3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine
  • 1-((E)-3-Pyridin-2-yl-3-p-tolyl-allyl)-pyrrolidinium
  • 2-((E)-3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine
  • 2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from light petroleumexp.
Melting point
59 to 61 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
278.40 g/molcalc.
Exact mass
278.1783 Dacalc.
LogP (octanol/water)
3.92calc.
Topological polar surface area
16.13 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
4calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.32calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C(CN1CCCC1)=C(c1ccccc1)c1ccccn1

C(CN1CCCC1)=C(c1ccccc1)c1ccccn1

3 rings, 20 atoms.

20 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Triprolidine suppliers

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All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Triprolidine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Allergic Agents
  • Histamine H1 Antagonists

Roles

  • H1-receptor antagonist
  • antagonist
  • histamine antagonist
  • histaminergic drug
  • neurotransmitter agent
  • pharmaceutical

Pharmacology

Triprolidine is a first generation antihistamine that is used for symptoms of allergic rhinitis and the common cold and as a short acting sedative. Triprolidine has not been linked to instances of clinically apparent acute liver injury.

How it is made

A commercial reaction is that of 2-pyrridyllithium with the appropriate Mannich ketone to give alcohol which, on dehydration, yields the antihistamine triprolidine

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Triprolidine is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Triprolidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Triprolidine, based on the data on this page

What is Triprolidine?

Triprolidine is an N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.

What is the CAS number of Triprolidine?

The CAS registry number of Triprolidine is 486-12-4.

What is the molecular formula and weight of Triprolidine?

The molecular formula of Triprolidine is C19H22N2 and its molar mass is 278.40 g/mol.

What is Triprolidine used for?

Use classes: Pharmaceuticals.

Is Triprolidine hazardous?

No GHS hazard classification for Triprolidine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Triprolidine?

Triprolidine is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Triprolidine?

CompoundList lists 2 suppliers of Triprolidine in India and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Triprolidine in India?

1 supplier in India list Triprolidine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Triprolidine?

Suppliers quote Triprolidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Triprolidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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