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Cosmetic preservatives

Tris(hydroxymethyl)nitromethane

Also known as 2-(Hydroxymethyl)-2-nitro-1,3-propanediol, Cimcool wafers, Trimethylolnitromethane

CAS 126-11-4Formula C4H9NO5Molar mass 151.12 g/molEC 204-769-5
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 7 suppliers listed
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Tris(hydroxymethyl)nitromethane chemical structure, C4H9NO5, CAS 126-11-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from ethyl acetate and benzene
Melting point
214 °C
Solubility
In water, 2.20 × 10⁺⁶ mg/L at 20 °C
HS code
290559
Category
Cosmetic preservatives
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Tris(hydroxymethyl)nitromethane?

Plain description, key identifiers and synonyms

Tris(hydroxymethyl)nitromethane is a chemical substance with the molecular formula C4H9NO5 and a molar mass of 151.12 g/mol. Its CAS registry number is 126-11-4. The IUPAC name is 2-(hydroxymethyl)-2-nitropropane-1,3-diol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(hydroxymethyl)-2-nitropropane-1,3-diol
CAS number
126-11-4 CAS number cross-checked
EC number
204-769-5
Molecular formula
C4H9NO5
UNII
3E794G4ZRB
MDL number
MFCD00007395
INCI name
TRIS-HYDROXYMETHYLNITROMETHANE
InChIKey
OLQJQHSAWMFDJE-UHFFFAOYSA-N
InChI
InChI=1S/C4H9NO5/c6-1-4(2-7,3-8)5(9)10/h6-8H,1-3H2
SMILES (canonical and isomeric)
C(C(CO)(CO)[N+](=O)[O-])O

Synonyms

  • 2-(Hydroxymethyl)-2-nitro-1,3-propanediol
  • Cimcool wafers
  • Trimethylolnitromethane
  • Nitroisobutylglycerol
  • 1,3-Propanediol, 2-(hydroxymethyl)-2-nitro-
  • Trihydroxymethylnitromethane
  • Nitrotris(hydroxymethyl)methane
  • 2-(Hydroxymethyl)-2-nitropropanediol
  • 2-Nitro-2-(hydroxymethyl)-1,3-propanediol
  • 2-Hydroxymethyl-2-nitro-1,3-propanediol
  • 2-Hydroxymethyl-2-nitropropane-1,3-diol
  • Isobutylglycerol, Nitro
  • 2-(Hydroxymethyl)-2-nitropropane-1,3-diol
  • Tris nitro
  • Isobutylglycerol, nitro-
  • Methane, trimethylolnitro-
  • 1,1,1-Tris(hydroxymethyl)nitromethane
  • Nitromethylidynetri(methanol)
  • 1, 2-(hydroxymethyl)-2-nitro-
  • 1,1-Tris(hydroxymethyl)nitromethane
  • Nitromethylidynetrimethanol
  • Nitrotrimethylolmethane
  • trishydroxymethylnitromethane
  • 2-(Hydroxymethyl)-2 nitro-1,3-propanediol
  • 2-(Hydroxymethyl)-2-nitro- 1,3-propanediol
Show all 32 synonyms
  • 2-(hydroxymethyl)-2-nitro-propane-1,3-diol
  • tris-hydroxymethylnitromethane
  • tris hydroxymethyl nitromethane
  • tris(hydroxymethyl) nitromethane
  • Tris(hydroxymethyl)nitromethane, 98%
  • S.S.T sump saver tablets (Salt/Mix)
  • 1,3-Propanediol, 2-(hydroxymethyl)-2-nitro

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from ethyl acetate and benzeneexp.
Odour
Odorlessexp.
Melting point
214 °Cexp.
Solubility
In water, 2.20 × 10⁺⁶ mg/L at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
151.12 g/molcalc.
Exact mass
151.0481 Dacalc.
LogP (octanol/water)
-2.02calc.
Topological polar surface area
103.8 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
10calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302 + H332Harmful if swallowed. Harmful if inhaled.
  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H335May cause respiratory irritation.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (22)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tris(hydroxymethyl)nitromethane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

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Where suppliers are based

7 suppliers in 2 countries

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Tris(hydroxymethyl)nitromethane price

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Uses and applications

What the substance is used for, by industry and function

Bactericide for inanimate objects. To inhibit bacterial growth in circulating industrial water systems, cutting oils, non-protein glues and sizings.

Disinfectant (general), microbicide/microbiostat (slime-forming bacteria and fungi) ... industrial preservative/preservative (bacteriostat).

Microbiocide and bacteriostat in disinfectants and industrial preservatives. Specifically ... used as an industrial preservative in metalworking fluids, secondary oil field recovery waters, paper mills, and commercial/industrial water cooling systems, as an in-can preservative in latex paints, polishes, and detergents, and as a disinfectant to control disease organisms in livestock and poultry areas on farms and equipment.

Industrial uses: Polymerization promoter, Other.

Consumer uses: Other.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name TRIS-HYDROXYMETHYLNITROMETHANE(antimicrobial)

Functional uses

  • Biocide

Cosmetic functions

  • Antimicrobial

How it is made

Three moles of formaldehyde react with nitromethane via the Henry reaction.

Prepn from trioxymethylene and nitromethane

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tris(hydroxymethyl)nitromethane is traded under.

HS 2905.59Indicative HS code

Halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols, other

World exports in 2024
$210M
+1.6% vs 2023, imports $201M
2019 to 2024
Top exporters
  1. China43.9%
  2. Germany11.6%
  3. Spain6.9%
Top importers
  1. Germany17.1%
  2. United States13.4%
  3. India * partner reported12.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tris(hydroxymethyl)nitromethane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tris(hydroxymethyl)nitromethane, based on the data on this page

What is Tris(hydroxymethyl)nitromethane?

Tris(hydroxymethyl)nitromethane is a chemical substance with the molecular formula C4H9NO5 and a molar mass of 151.12 g/mol. Its CAS registry number is 126-11-4. The IUPAC name is 2-(hydroxymethyl)-2-nitropropane-1,3-diol.

What is the CAS number of Tris(hydroxymethyl)nitromethane?

The CAS registry number of Tris(hydroxymethyl)nitromethane is 126-11-4.

What is the molecular formula and weight of Tris(hydroxymethyl)nitromethane?

The molecular formula of Tris(hydroxymethyl)nitromethane is C4H9NO5 and its molar mass is 151.12 g/mol.

What is Tris(hydroxymethyl)nitromethane used for?

Bactericide for inanimate objects. To inhibit bacterial growth in circulating industrial water systems, cutting oils, non-protein glues and sizings. Disinfectant (general), microbicide/microbiostat (slime-forming bacteria and fungi) ... industrial preservative/preservative (bacteriostat).

Is Tris(hydroxymethyl)nitromethane hazardous?

Tris(hydroxymethyl)nitromethane carries the GHS signal word "Warning". Main hazards: harmful if swallowed. harmful if inhaled, harmful if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tris(hydroxymethyl)nitromethane?

Tris(hydroxymethyl)nitromethane is usually classified under HS code 290559 (Halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tris(hydroxymethyl)nitromethane?

CompoundList lists 7 suppliers of Tris(hydroxymethyl)nitromethane in United States and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Tris(hydroxymethyl)nitromethane?

Suppliers quote Tris(hydroxymethyl)nitromethane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tris(hydroxymethyl)nitromethane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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