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Peptides

Trofinetide

Also known as Daybue, trofinetida, L-Glutamic acid, glycyl-2-methyl-L-prolyl-

CAS 853400-76-7Formula C13H21N3O6Molar mass 315.33 g/molEC 863-268-5
11 suppliers listed Drug substance
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Trofinetide chemical structure, C13H21N3O6, CAS 853400-76-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
853400-76-7
Formula
C13H21N3O6
Molar mass
315.33 g/mol
EC number
863-268-5
HS code
293399
Category
Peptides

What is Trofinetide?

Plain description, key identifiers and synonyms

Trofinetide is a tripeptide comprising of glycine, 2-methyl-L-proline, and L-glutamic acid joined in sequence by peptide linkages. It is the first and only treatment approved by the FDA specifically indicated for Rett syndrome in adults and pediatric patients two years of age and older. It has a role as a neuroprotective agent and an anti-inflammatory agent. It is a secondary carboxamide, a tertiary carboxamide, a dicarboxylic acid, a pyrrolidinecarboxamide, a tripeptide and a primary amino compound. It is functionally related to a glycine and a L-glutamic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acid
CAS number
853400-76-7
EC number
863-268-5
Molecular formula
C13H21N3O6
UNII
Z2ME8F52QL
MDL number
MFCD28502204
InChIKey
BUSXWGRAOZQTEY-SDBXPKJASA-N
InChI
InChI=1S/C13H21N3O6/c1-13(5-2-6-16(13)9(17)7-14)12(22)15-8(11(20)21)3-4-10(18)19/h8H,2-7,14H2,1H3,(H,15,22)(H,18,19)(H,20,21)/t8-,13-/m0/s1
Canonical SMILES
CC1(C(=O)NC(CCC(=O)O)C(=O)O)CCCN1C(=O)CN
Isomeric SMILES
C[C@]1(CCCN1C(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)O

Synonyms

  • Daybue
  • trofinetida
  • L-Glutamic acid, glycyl-2-methyl-L-prolyl-
  • (2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acid
  • trofinetidum
  • (2S)-2-(((2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl)amino)pentanedioic acid
  • (2S)-2-(((2S)-1-(2-aminoacetyl)-2-methylpyrrolidin-2-yl)formamido)pentanedioic acid
  • Glycyl-2-methyl-L-prolyl-L-glutamic acid
  • Trofinetide(NNZ2566)
  • NNZ 2566
  • glycyl-L-2-methylprolyl-L-glutamic acid
  • (S)-2-((S)-1-(2-Aminoacetyl)-2-methylpyrrolidine-2-carboxamido)pentanedioic acid
  • Trofinetide (>90%)
  • ((S)-1-glycyl-2-methylpyrrolidine-2-carbonyl)-L-glutamic acid
  • Glycyl-2-methyl-L-prolyl-L-glutamic Acid, Glycyl-L-2-methylprolyl-L-glutamic Acid, NNZ 2566
  • Daybue (TN)
  • Daybue stix
  • Trofinetide (USAN/INN)
  • Glutamic acid, glycyl-prolyl-
  • WHO 10076
  • analogue 4
  • (2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methyl-pyrrolidine-2-carbonyl]amino]pentanedioic Acid
  • glycyl-alpha-methyl-L-prolyl-L-glutamic acid
  • Trofinetide,NNZ 2566,NNZ2566,Inhibitor,inhibit

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
315.33 g/molcalc.
Exact mass
315.143 Dacalc.
LogP (octanol/water)
-1.24calc.
Topological polar surface area
150 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
7calc.
Heavy atoms
22calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.69calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCNC1

C1CCNC1

1 ring, 5 atoms, the Pyrrolidine ring system.

22,348 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Trofinetide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 11 suppliers
11 of 11 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

11 suppliers in 4 countries

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Trofinetide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • anti-inflammatory agent
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • vulnerary

Pharmacology

The mechanism of action of trofinetide is as a Cytochrome P450 3A4 Inhibitor, and Organic Anion Transporting Polypeptide 1B1 Inhibitor, and Organic Anion Transporting Polypeptide 1B3 Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trofinetide is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Trofinetide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trofinetide, based on the data on this page

What is Trofinetide?

Trofinetide is a tripeptide comprising of glycine, 2-methyl-L-proline, and L-glutamic acid joined in sequence by peptide linkages. It is the first and only treatment approved by the FDA specifically indicated for Rett syndrome in adults and pediatric patients two years of age and older.

What is the CAS number of Trofinetide?

The CAS registry number of Trofinetide is 853400-76-7.

What is the molecular formula and weight of Trofinetide?

The molecular formula of Trofinetide is C13H21N3O6 and its molar mass is 315.33 g/mol.

What is Trofinetide used for?

Known uses and roles of Trofinetide include anti-inflammatory agent, neuroprotective agent, pharmaceutical, protective agent and vulnerary.

Is Trofinetide hazardous?

No GHS hazard classification for Trofinetide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Trofinetide?

Trofinetide is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trofinetide?

CompoundList lists 11 suppliers of Trofinetide in China, Italy, India and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Trofinetide in India?

2 suppliers in India list Trofinetide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Trofinetide?

Suppliers quote Trofinetide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trofinetide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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