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Skin conditioning agents and actives

Trolox

Also known as 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, Trolox c, 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

CAS 53188-07-1Formula C14H18O4Molar mass 250.29 g/molEC 258-422-8
GHS signal word: Warning. Pictograms: Harmful or irritant 90 suppliers listed
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Trolox chemical structure, C14H18O4, CAS 53188-07-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
53188-07-1
Formula
C14H18O4
Molar mass
250.29 g/mol
EC number
258-422-8
HS code
293299
Category
Skin conditioning agents and actives

What is Trolox?

Plain description, key identifiers and synonyms

Trolox is a chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capacity of complex mixtures. It has a role as a ferroptosis inhibitor, an antioxidant, a radical scavenger, a neuroprotective agent and a Wnt signalling inhibitor. It is a chromanol, a monocarboxylic acid and a member of phenols.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid
CAS number
53188-07-1 CAS number cross-checkedOther or deprecated CAS: 56305-04-5
EC number
258-422-8
Molecular formula
C14H18O4
UNII
S18UL9710X
MDL number
MFCD00006846
INCI name
TROLOX
InChIKey
GLEVLJDDWXEYCO-UHFFFAOYSA-N
InChI
InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)
SMILES (canonical and isomeric)
CC1=C(C2=C(CCC(O2)(C)C(=O)O)C(=C1O)C)C

Synonyms

  • 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
  • Trolox c
  • 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
  • 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid
  • 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid
  • (+--)-trolox
  • (+--)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
  • 2h-1-benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (+--)-
  • 6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
  • 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-
  • 6-hydroxy-2,5,7,8-tetramethyl-chromane-2-carboxylic acid
  • ( inverted exclamation markA)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
  • (2S)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
  • 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylic acid
  • (+/-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
  • Trolox(TM)
  • (S)-Trolox?
  • 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (+-)-
  • (+/-)-Trolox
  • 6-Hydroxy-2,5,7,8-tetramethyl-2-chromancarboxylic acid
  • 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid
  • (+/-)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
  • 6-hydroxy-2,5,7,8-tetramethylchromanic acid
  • 6-hydroxy-2,5,7,8-tetramethychroman-2-carboxylic acid
  • 6-Hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic acid #
Show all 33 synonyms
  • (?-6-Hydroxy-2,5,7,8-Tetramethylchromane-2-Carboxylic Acid
  • (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)carboxylic acid
  • (+/-)- 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
  • (R,S)-6-hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic acid
  • (+/-)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, 97%
  • 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, (+/-)-
  • 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-benzopyran-2- carboxylic acid
  • 6-hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
250.29 g/molcalc.
Exact mass
250.1205 Dacalc.
LogP (octanol/water)
2.49calc.
Topological polar surface area
66.76 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCCO2

c1ccc2c(c1)CCCO2

2 rings, 10 atoms, the Chroman ring system.

4,102 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Trolox suppliers

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Where suppliers are based

90 suppliers in 14 countries

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Trolox price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name TROLOX(skin conditioning)

Pharmacological actions

  • Antioxidants

Roles

  • Wnt signalling inhibitor
  • antioxidant
  • ferroptosis inhibitor
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • radical scavenger

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trolox is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Trolox is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trolox, based on the data on this page

What is Trolox?

Trolox is a chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capacity of complex mixtures.

What is the CAS number of Trolox?

The CAS registry number of Trolox is 53188-07-1. Other or deprecated CAS numbers: 56305-04-5.

What is the molecular formula and weight of Trolox?

The molecular formula of Trolox is C14H18O4 and its molar mass is 250.29 g/mol.

What is Trolox used for?

Known uses and roles of Trolox include antioxidants in cosmetics and personal care, skin conditioning agents in cosmetics and personal care, wnt signalling inhibitor, antioxidant, ferroptosis inhibitor and 7 more.

Is Trolox hazardous?

Trolox carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Trolox?

Trolox is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trolox?

CompoundList lists 90 suppliers of Trolox in United States, China, Germany, United Kingdom and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Trolox?

Suppliers quote Trolox on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trolox

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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