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Heterocyclic compounds

Vancomycin hydrochloride

Also known as Vancomycin HCL, Vancomycin, hydrochloride, Firvanq

CAS 1404-93-9Formula C66H76Cl3N9O24Molar mass 1,485.73 g/molEC 604-193-8
GHS signal word: Warning. Pictograms: Harmful or irritant 114 suppliers listed Drug substance
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Vancomycin hydrochloride chemical structure, C66H76Cl3N9O24, CAS 1404-93-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1404-93-9
Formula
C66H76Cl3N9O24
Molar mass
1,485.73 g/mol
EC number
604-193-8
HS code
294190
Category
Heterocyclic compounds

What is Vancomycin hydrochloride?

Plain description, key identifiers and synonyms

Vancomycin Hydrochloride is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,2R,18R,19R,22S,25R,28R,40S)-48-[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid, hydrochloride
CAS number
1404-93-9 CAS number cross-checkedOther or deprecated CAS: 197638-25-8
EC number
604-193-8
Molecular formula
C66H76Cl3N9O24
UNII
71WO621TJD
InChIKey
LCTORFDMHNKUSG-XTTLPDOESA-N
InChI
InChI=1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1
Canonical SMILES
CNC(CC(C)C)C(=O)NC1C(=O)NC(CC(N)=O)C(=O)NC2C(=O)NC3C(=O)NC(C(=O)NC(C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)C(O)c3ccc(c(Cl)c3)Oc3cc2cc(c3OC2OC(CO)C(O)C(O)C2OC2CC(C)(N)C(O)C(C)O2)Oc2ccc(cc2Cl)C1O.Cl
Isomeric SMILES
C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl

Synonyms

  • Vancomycin HCL
  • Vancomycin, hydrochloride
  • Firvanq
  • Vancocin hydrochloride
  • Vancoled
  • Vancomycin, monohydrochloride
  • Vancor
  • Vancomycin (as hydrochloride)
  • Vancocin hydrochloride in plastic container
  • Vancocin Matrigel
  • Vanoled
  • Firvanq kit
  • Hydrochloride, Vancomycin
  • Sterile Vancomycin Hydrochloride
  • Vancomycin Hydrochloride for Oral Solution
  • Vancomycin hydrochloride in plastic container
  • Vancomycin monohydrochloride
  • Vancomycin hydrochloride from Streptomyces orientalis
  • Vancomycin (hydrochloride)
  • AeroVanc
  • Vancocine hydrochloride
  • Vancomycin hydrochloride (ep monograph)
  • C66H76Cl3N9O24
  • Vancomycinhydrochloride
  • Vancomycin HCl - pharma grade
Show all 30 synonyms
  • Cancocin hydrochloride
  • Vancomycin xhcl
  • Second International Standard for Vancomycin
  • Vancomycin hydrochloride CRS
  • Vancomycin hydrochloride (1:1)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,485.73 g/molcalc.
Exact mass
1,483.4069 Dacalc.
LogP (octanol/water)
0.53calc.
Topological polar surface area
530.5 Ųcalc.
Hydrogen bond donors
19calc.
Hydrogen bond acceptors
25calc.
Rotatable bonds
13calc.
Heavy atoms
102calc.
Rings
12calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.42calc.
Formal charge
0calc.
Stereocentres
18calc.
Components
2calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCc2ccc(cc2)Oc2cc3cc(c2OC2OCCCC2OC2CCCCO2)Oc2ccc(cc2)CC2NC(=O)C(NC(=O)C3NC(=O)CN1)c1cccc(c1)-c1ccccc1CNC2=O

O=C1CCc2ccc(cc2)Oc2cc3cc(c2OC2OCCCC2OC2CCCCO2)Oc2ccc(cc2)CC2NC(=O)C(NC(=O)C3NC(=O)CN1)c1cccc(c1)-c1ccccc1CNC2=O

12 rings, 69 atoms.

17 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (18)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Vancomycin hydrochloride suppliers

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Where suppliers are based

114 suppliers in 19 countries

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Vancomycin hydrochloride price

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Uses and applications

What the substance is used for, by industry and function

Pharmacology

Vancomycin hydrochloride is an antibacterial prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain bacterialinfections, such as infections caused by Clostridium difficile and Staphylococcus aureus.

Clostridium difficile and Staphylococcus aureus are bacteria that can cause opportunistic infections (OIs) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems-such as people with HIV-than in people with healthy immune systems.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Vancomycin hydrochloride is traded under.

HS 2941.90Indicative HS code

Antibiotics, other

World exports in 2024
$6.39B
+2.3% vs 2023, imports $6.97B
2019 to 2024
Top exporters
  1. China39.7%
  2. United States11.3%
  3. Switzerland * partner reported10.9%
Top importers
  1. Italy15.0%
  2. India * partner reported12.0%
  3. China8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Vancomycin hydrochloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Vancomycin hydrochloride, based on the data on this page

What is Vancomycin hydrochloride?

Vancomycin Hydrochloride is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci.

What is the CAS number of Vancomycin hydrochloride?

The CAS registry number of Vancomycin hydrochloride is 1404-93-9. Other or deprecated CAS numbers: 197638-25-8.

What is the molecular formula and weight of Vancomycin hydrochloride?

The molecular formula of Vancomycin hydrochloride is C66H76Cl3N9O24 and its molar mass is 1,485.73 g/mol.

Is Vancomycin hydrochloride hazardous?

Vancomycin hydrochloride carries the GHS signal word "Warning". Main hazards: causes skin irritation, may cause an allergic skin reaction, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Vancomycin hydrochloride?

Vancomycin hydrochloride is usually classified under HS code 294190 (Antibiotics, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Vancomycin hydrochloride?

CompoundList lists 114 suppliers of Vancomycin hydrochloride in China, United States, India, Germany and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Vancomycin hydrochloride in India?

13 suppliers in India list Vancomycin hydrochloride on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Vancomycin hydrochloride?

Suppliers quote Vancomycin hydrochloride on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Vancomycin hydrochloride

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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