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Oncology and immunology drugs

Vatalanib

Also known as N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine, Pynasunate, Vatalinib

CAS 212141-54-3Formula C20H15ClN4Molar mass 346.82 g/mol
13 suppliers listed
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Vatalanib chemical structure, C20H15ClN4, CAS 212141-54-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
212141-54-3
Formula
C20H15ClN4
Molar mass
346.82 g/mol
HS code
293339
Category
Oncology and immunology drugs

What is Vatalanib?

Plain description, key identifiers and synonyms

Vatalanib is a member of the class of phthalazines that is phthalazine in which the hydrogens at positions 1 and 4have been replaced by a p-chlorophenylamino group and a pyridin-4-ylmethyl group, respectively. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and a vascular endothelial growth factor receptor antagonist. It is a member of pyridines, a member of phthalazines, a secondary amino compound and a member of monochlorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
CAS number
212141-54-3 CAS number cross-checked
Molecular formula
C20H15ClN4
UNII
5DX9U76296
MDL number
MFCD08458963
InChIKey
YCOYDOIWSSHVCK-UHFFFAOYSA-N
InChI
InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
SMILES (canonical and isomeric)
C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4

Synonyms

  • N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
  • Pynasunate
  • Vatalinib
  • CGP 79787
  • N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
  • vatalanibum
  • PTK787/ZK 222584
  • 1-(4-chloroanilino)-4-(pyridylmethyl)phthalazine
  • 1-(4-chloroanilino)-4-(pyridylmethyl)phthalazine dihydrochloride
  • Vatalanib base
  • Vatalanib free base
  • Vatalanib (free base)
  • 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-
  • 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-
  • PTK/ZK
  • N-(4-chlorophenyl)-4-[(pyridin-4-yl)methyl]phthalazin-1-amine
  • Vatalanib (dihydrochloride)
  • Vatalanib HCl
  • PTK787 dihydrochloride, CGP-797870 dihydrochloride, ZK-222584 dihydrochloride
  • 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine
  • (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine
  • PTK/ZK free base
  • Kinome_3657
  • Vatalanib (PTK787)
  • Vatalanib (USAN/INN)
Show all 31 synonyms
  • CGP-79787 free base
  • ZK-222584 free base
  • N-(4-chlorophenyl)-4-(4-pyridylmethyl)phthalazin-1-amine
  • (A) PTK787
  • 1-Phtalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-
  • N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phtalazin-1-amine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
346.82 g/molcalc.
Exact mass
346.0985 Dacalc.
LogP (octanol/water)
5.01calc.
Topological polar surface area
50.7 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
25calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.05calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1

c1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1

4 rings, 24 atoms, the N-Phenyl-4-(pyridin-4-ylmethyl)phthalazin-1-amine ring system.

20 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Vatalanib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 13 suppliers
13 of 13 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

13 suppliers in 4 countries

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Vatalanib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Protein Kinase Inhibitors

Roles

  • angiogenesis inhibitor
  • antagonist
  • antifibrotic agent
  • antineoplastic agent
  • enzyme inhibitor
  • ophthalmology drug
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor
  • vascular endothelial growth factor receptor antagonist

Pharmacology

Vatalanib is an orally bioavailable anilinophthalazine with potential antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2, both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Vatalanib is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Vatalanib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Vatalanib, based on the data on this page

What is Vatalanib?

Vatalanib is a member of the class of phthalazines that is phthalazine in which the hydrogens at positions 1 and 4have been replaced by a p-chlorophenylamino group and a pyridin-4-ylmethyl group, respectively. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit.

What is the CAS number of Vatalanib?

The CAS registry number of Vatalanib is 212141-54-3.

What is the molecular formula and weight of Vatalanib?

The molecular formula of Vatalanib is C20H15ClN4 and its molar mass is 346.82 g/mol.

What is Vatalanib used for?

Known uses and roles of Vatalanib include anticancer drugs in pharmaceuticals, biochemical and pharmacological tools in research and laboratory, angiogenesis inhibitor, antagonist, antifibrotic agent and 8 more.

Is Vatalanib hazardous?

No GHS hazard classification for Vatalanib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Vatalanib?

Vatalanib is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Vatalanib?

CompoundList lists 13 suppliers of Vatalanib in China, United States, Canada and India. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Vatalanib in India?

1 supplier in India list Vatalanib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Vatalanib?

Suppliers quote Vatalanib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Vatalanib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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